OHSU Knight Cancer Institute

Davis Lab

The Davis Lab focuses on developing new therapeutic approaches for aggressive pediatric, adolescent, young adult and adult sarcomas.  

Current active projects include:

  • Treatment of molecularly-selected bone and soft tissue sarcomas with CDK4 inhibitors to synchronize and sensitize tumor cells to chemotherapy.
  • Characterizing and harnessing the tumor immune microenvironment of osteosarcoma.
  • Ongoing collaborations with Department of Pediatrics faculty member Dr. Monika Davare:
    • Identifying, characterizing and targeting kinase alterations in sarcomas.
    • Developing a novel small molecule therapy for Ewing sarcoma.