OHSU Core service centers

Core Service Profile Overview Sheet

Advanced Computing Center - Consulting, research storage, application hosting, support for research computing systems.
Service Profile

Advanced Imaging Research Center - Novel Magnetic Resonance Imaging (MRI), data analysis, and user education. 

Advanced Light Microscopy Core - Access to and education on the use of advanced instrumentation for fluorescence microscopy in cells, tissues, and animals.
Service Profile

Bioanalytical/Pharmacokinetics - Support and consultation for the analysis of small molecules using state-of-the-art LC-MS/MS, GC/MS, or HPLC instrumentation. 
Service Profile

Bioinformatics - Experimental Design and Analysis support for high dimensional data 
(e.g., RNA-seq, DNA-seq, ChIP-seq, CyTOF, etc). Data stewardship, management, and dissemination support.

Bioinformatics & Biostatistics Core (BBC) at ONPRC - Supports all types of biostatistics and primarily DNA/RNA-sequencing-related bioinformatics. Provides analysis, study design, advising, and grant support.
Service Profile

BioLibrary - Fresh, frozen, OCT, FFPE tissues and blood derivatives; prospective whole blood collection; PI-driven consenting of patients; digital slide imaging.

Biostatistics & Design Program - Statistical guidance, analysis, and study design for proposal development, grant submissions and research projects including: data management, statistical programming, report preparation, and assistance with manuscripts.
Service Profile

Clinical and Translational Research Core Services - Study Coordination, Education, and Career development, Biostatistics, Biomedical Informatics, Investigator Support and Integration, Community and Practice Research Funding.

Elemental Analysis Core - ICP-MS: determination of elemental content, sample preparation, data analysis, and consolation.
Service Profile

Epigenetics Consortium - Sample preparation and bioinformatics analysis for epigenetics assays (e.g. Methyl-seq, Chip-seq, ATAC-seq)

Flow Cytometry - Cell sorting and analytical flow cytometry, data analysis, consultation, and user education and training.
Service Profile

Histopathology - Specimen imbedding, sectioning, staining, and immunohistochemistry. 
Service Profile

Integrated Genomics Laboratory - Technologies, services, and expertise for genome-wide and targeted RNA and DNA analysis.

MedEdNet Survey Services – Support and consultation for scannable paper surveys and web based surveys. Services include survey set up, administration, and data processing.

Medicinal Chemistry Core - Investigates the interactions between small molecules and biological systems by providing medicinal chemistry and chemical biology expertise and organic synthesis support.
Service Profile

Multiscale Microscopy Core - State-of-the-art electron and light microscopy facility providing imaging services, access and technical support to OHSU and external customers.
Service Profile

Proteomics - Mass spectrometric services to allow protein identification, detection of post-translational modifications, and profiling of changes in relative protein abundance.
Service Profile

Small Animal Research Imaging Core - MicroPET-SPECT/CT, high frequency ultrasound, and biophotonics imaging services to evaluate anatomy, tissue function, cellular and molecular phenotype, blood/fluid flow, and metabolism.

Transgenic Mouse Models - Development of genetically engineered mouse models, cryopreservation, and other services.
Service Profile

Virology - Production of viral vectors, virus stocks and antigens. Viral diagnostics for virus quantification and serology. User consultation and education.

USR Core Pilot Awards - FY2020

The University Shared Resources (USR) program is issuing a call for applications for the FY2020 USR Core Pilot Awards. This notice is available on the Research News blog, and in the weekly Research Alerts newsletter. Please see the additional details about how to submit applications below.  Applications are due by November 13, 2019.

For questions about this program, please contact Andy Chitty.

For questions about the submission process on CAP, please contact funding@ohsu.edu.

These awards support OHSU faculty and USR cores by providing pilot funding for principal investigators, especially for supporting generation of data for new grant applications and development of new workflows, assays, or technologies within the cores. 

Applicants must collaborate with one or more USR core directors in developing the project. Applicants must be OHSU faculty members; however, projects that support a trainee’s work are eligible. The competition is open to all OHSU faculty in all schools, institutes, and centers. Previous awardees are eligible to apply with a new project, but new applicants may be given priority. 

Individual award amounts will vary depending on projected expenses in the proposed core and will be based on need. The upper limit for pilot awards is $10,000, although applications of lower amounts may receive priority. The full award must be used in the core(s) specified in the grant application and only for the services described. There is a combined total of $100,000 reserved for this funding mechanism in FY 2020. 

•   PIs must contact USR core director(s) to assess feasibility and discuss budgets prior to applying.  (A single award may be used to support a project that involves more than one USR core.) 

• All funds must be spent in one or more USR cores. No FTE, supplies, or other expenses outside the USR core will be allowed. Funds can be used for data generation, consultations, or other technical services provided by the cores. 

• Funds are to be spent on services associated with the project described in the pilot grant application only.

• Funds should be spent within 12 months of announcement of the award, but consideration for longer term projects will be considered on a case by case basis. 

• Applicants must cite this support and core contributions in relevant publications. 

• Applicants must acknowledge specific USR cores in relevant publications. 

• The USR will follow up directly with each grant recipient multiple times over time to assess the pilot programs level of success. By accepting this award, the applicant agrees to provide feedback to the USR on the results of the awards given.

Applicants must contact the USR core director(s) of the proposed core(s) to discuss the proposal. The core director will provide a feasibility assessment and a technical review, which will be submitted along with the proposal. Proposals that meet the goals of the program—to support pilot data for grant applications—will be deemed competitive. Proposals will also undergo an administrative review. 

Applications are due November 13, 2019 and must be completed online at OHSU’s Competitive Application Portal (CAP). Log in using your OHSU credentials and click on “University Shared Resources Pilot Funding ” under Open Internal Funding Opportunities. You must fill out a form that includes several acknowledgements that must be read and accepted before the application can be submitted.

The following supporting documents must also be uploaded as a single PDF. Use 11-pt font and margins of 0.5” on each side:

  1. A 1-page application that includes the following information:
    1. Description of the project and the need for pilot data. Explain the goal of the project and how the data generated from the pilot project will be used to support it. Specifically, will funds be used to generate data for future grant funding, the development of new technology, new methods, other?
  2. Supporting documents:
    1. Project budget and justification. Include information about the financial status of the project—for example, is the PI on bridge funding? Is this project needed for a new grant that currently has no source of funding? This information will help us determine the return on investment in the future, but it will not necessarily affect the funding decision.
    2. References
    3. Project timeline (to demonstrate that funds will be spent within 12 months). If more than one core is used, outline timeline for each core.
    4. PI’s NIH-formatted biosketch

Single cell analysis resources at OHSU

Advancements in technology now permit the analysis of samples at the single cell level.  The University Shared Resources and others at OHSU are beginning to utilize these exciting advances.

  • Massively Parallel Sequencing Shared Resource
  • Flow Cytometry
    • In support of single cell studies, the Flow Cytometry Shared Resource has the capability of sorting discrete populations of cells as well as individual cells into tubes and/or plates. These cell sorts can be performed on the basis of up to 18 fluorescent parameters.
    • Please contact Philip Streeter in the Flow Cytometry Shared Resource
  • Histopathology
  • Mass Spectrometry
    • Stay tuned for future single cell proteomics and single particle elemental analysis

If you have questions, would like to request additional services, or see information missing from this page, please contact Aaron Larson in the University Shared Resources office.

More core resources

University Shared Resource Core boilerplates

If you are planning to include an OHSU Shared Resource in a grant or other project proposal, please contact the Shared Resource/Core director for guidance with assay/service selection, study design, cost estimates, and letters of support.

To request a USR Core boilerplate, please complete and submit the Boilerplate Request Form.

School of Medicine Faculty Innovation Fund pilot program continues

The School of Medicine encourages innovative and diverse investigations by offering up to $5000 for core spending. 
More info and application guidelines

Acknowledgement and authorship policies

Acknowledgement policy

The use of data generated in a core facility in a grant application, progress report or publication contains the implicit understanding that the PI or authors will acknowledge the use of the core facility.  Since many of our facilities are supported by federal agencies, such acknowledgments are essential for obtaining continuing support. 

Authorship policy

If core personnel provide significant intellectual input to the results submitted for publication, then it is reasonable and appropriate to include them as co-authors.  Since circumstances vary widely, each case should be considered individually, and the core should be consulted for review prior to publishing.