OHSU Core service centers

Core Service Profile Overview Sheet

Advanced Computing Center - Consulting, research storage, application hosting, support for research computing systems.
Service Profile

Advanced Imaging Research Center - Novel Magnetic Resonance Imaging (MRI), data analysis, and user education. 

Advanced Light Microscopy Core - Access to and education on the use of advanced instrumentation for fluorescence microscopy in cells, tissues, and animals.
Service Profile

Bioanalytical/Pharmacokinetics - Support and consultation for the analysis of small molecules using state-of-the-art LC-MS/MS, GC/MS, or HPLC instrumentation. 
Service Profile

Bioinformatics - Experimental Design and Analysis support for high dimensional data 
(e.g., RNA-seq, DNA-seq, ChIP-seq, CyTOF, etc). Data stewardship, management, and dissemination support.

BioLibrary - Fresh, frozen, OCT, FFPE tissues and blood derivatives; prospective whole blood collection; PI-driven consenting of patients; digital slide imaging

Biomolecular Structure Laboratory - Crystallization, x-ray diffraction and computational analysis of macromolecules and complexes. 

Biostatistics & Design Program - Statistical guidance, analysis, and study design for proposal development, grant submissions and research projects including: data management, statistical programming, report preparation, and assistance with manuscripts.
Service Profile

Clinical and Translational Research Core Services - Study Coordination, Education, and Career development, Biostatistics, Biomedical Informatics, Investigator Support and Integration, Community and Practice Research Funding.

DNA Services - Cell-line authentication, and oligonucleotide synthesis. 
Service Profile

Cell Line Authentication (CLA) Service

Elemental Analysis Core - ICP-MS: determination of elemental content, sample preparation, data analysis, and consolation.
Service Profile

Epigenetics Consortium - Sample preparation and bioinformatics analysis for epigenetics assays (e.g. Methyl-seq, Chip-seq, ATAC-seq)

Flow Cytometry - Cell sorting and analytical flow cytometry, data analysis, consultation, and user education and training.
Service Profile

Gene Profiling - RNA/DNA isolation and quality assessment; Microarrays (Affymetrix, Illumina) and real-time PCR for RNA profiling and DNA variation analysis.
Service Profile

Histopathology - Specimen imbedding, sectioning, staining, and immunohistochemistry. 
Service Profile

Massively Parallel Sequencing - Sample preparation and genomic scale sequencing services on the Illumina HiSeq 2500 and NextSeq 500.
Service Profile

MedEdNet Survey Services – Support and consultation for scannable paper surveys and web based surveys. Services include survey set up, administration, and data processing.

Medicinal Chemistry Core - Investigates the interactions between small molecules and biological systems by providing medicinal chemistry and chemical biology expertise and organic synthesis support.
Service Profile

Multiscale Microscopy Core - State-of-the-art electron and light microscopy facility providing imaging services, access and technical support to OHSU and external customers.
Service Profile

ONPRC Bioinformatics & Biostatistics Core - Supports all types of biostatistics and primarily DNA/RNA-sequencing-related bioinformatics. Provides analysis, study design, advising, and grant support.
Service Profile

Proteomics - Mass spectrometric services to allow protein identification, detection of post-translational modifications, and profiling of changes in relative protein abundance.
Service Profile

Small Animal Research Imaging Core - MicroPET-SPECT/CT, high frequency ultrasound, and biophotonics imaging services to evaluate anatomy, tissue function, cellular and molecular phenotype, blood/fluid flow, and metabolism.

Transgenic Mouse Models - Development of genetically engineered mouse models, cryopreservation, and other services.
Service Profile

Virology - Production of viral vectors, virus stocks and antigens. Viral diagnostics for virus quantification and serology. User consultation and education.

Single cell analysis at OHSU

The University Shared Resources program and the Integrated Genomics Laboratory, along with other OHSU core facilities, are working together to provide information on technologies and data analysis solutions for single cell analysis.

Speakers and discussion topics from the August 30th, 2018 Single Cell Analysis Forum (recording available here) were:

  • Andrew Adey - assistant professor, Molecular and Medical Genetics
    • Sequencing-based single-cell omics: Part I
  • Hisham Mohammed - scientist, CEDAR - Knight Cancer Institute
    • Sequencing-based single-cell omics: Part II
  • Robert Searles, director, Massively Parallel Sequencing Shared Resource (MPSSR)
    • 10x Genomics Chromium RNA-Seq system
      • Please contact Robert Searles for more information about single cell assay support available through the MPSSR.
  • Philip Streeter, director, Flow Cytometry Shared Resource
    • Flow cytometry for single-cell omics
  • The interim survey results following the August 30th Single Cell Analysis Forum have been tabulated, though we encourage you to take the survey, available here.
    • If you have any questions about the survey, please contact Aaron Larson.

2018 Core Pilot Grant Program

The University Shared Resources (USR) pilot fund grants provide investigators with funding that is instrumental in advancing their research and access to technology on campus. In FY2018, we received nearly double the number of applications from the previous year, as investigators discover the high value in receiving seed funding to move their research forward using state-of-the-art technology.

We hope to be able to continue this program in FY2019. Eligible investigators may receive up to $10,000 in pilot funding to initiate their project research.

Eligibility

  • Applicants can use any OHSU core to be considered eligible to receive pilot funding, but preference will be given to USR cores
    • Cores must receive all awarded funds
    • If a portion of the job must be sub-contracted, sub-contracts must be arranged by the core
  • The competition is open to all OHSU faculty in all schools, institutes, and centers
    • Projects that support a trainee's work are also eligible
  • Previous awardees are eligible to apply with a new project, but new applicants may be given priority
  • Applicants must consult with the director(s) of their designated core(s) prior to application submission

If you are interested in learning more about the USR Core Pilot Grant Program, please contact USR Director Andrew Chitty.

School of Medicine Faculty Innovation Fund pilot program continues

The School of Medicine encourages innovative and diverse investigations by offering up to $5000 for core spending. 
More info and application guidelines

Cores corner news and USR events

University Shared Resource Core boilerplates

If you are planning to include an OHSU Shared Resource in a grant or other project proposal, please contact the Shared Resource/Core director for guidance with assay/service selection, study design, cost estimates, and letters of support.

To request a USR Core boilerplate, please complete and submit the Boilerplate Request Form.

Acknowledgement and authorship policies

Acknowledgement policy

The use of data generated in a core facility in a grant application, progress report or publication contains the implicit understanding that the PI or authors will acknowledge the use of the core facility.  Since many of our facilities are supported by federal agencies, such acknowledgments are essential for obtaining continuing support. 

Authorship policy

If core personnel provide significant intellectual input to the results submitted for publication, then it is reasonable and appropriate to include them as co-authors.  Since circumstances vary widely, each case should be considered individually, and the core should be consulted for review prior to publishing.

More core resources