Skye C. Mayo M.D., M.P.H., F.A.C.S.

Photo of Skye C. Mayo, M.D., M.P.H., F.A.C.S.
Faculty profile
  • Assistant Professor of Surgery, Division of Surgical Oncology

Assistant Professor of Surgery, Division of Surgical Oncology School of Medicine

Accepting new patients

4.8 out of 5 (233 Ratings, 77 Comments)


  • Cancer
  • Surgery

Special focus on

  • Biliary Tract Cancer
  • Liver Cancer
  • Metastatic Colorectal Cancer
  • Pancreatic Cancer
  • Retroperitoneal Sarcoma


  • M.D., Oregon Health & Science University School of Medicine 2006
  • M.P.H., Oregon Health & Science University School of Public Health and Preventive Medicine 2006
  • Internship:

    • General Surgery, The Johns Hopkins Hospital, 2006
  • Residency:

    • General Surgery, The Johns Hopkins Hospital, 2013
  • Fellowship:

    • Cancer Immunology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Institutions, 2011
    • Complex General Surgical Oncology, Hepatopancreatobiliary Focus, Memorial Sloan-Kettering Cancer Center, 2013-15
  • Certifications:

    • American Board of Surgery, General Surgery, 2013
    • American Board of Surgery, Complex General Surgical Oncology, 2016


Dr. Skye Mayo is board certified in both Complex General Surgical Oncology and in General Surgery. His clinical practice serves patients with tumors of the liver, bile ducts, and pancreas. He also treats patients with gall bladder cancer, cancers of the stomach and digestive system, and retroperitoneal sarcomas.  His research focuses on helping patients with cancers that have spread to or arise in the liver, such as colorectal cancer and intrahepatic cholangiocarcinoma.

Dr. Mayo is an Oregon native: born in Eastern Oregon and raised in Central Oregon. During his surgical residency at Johns Hopkins his clinical and research work focused on the treatment of patients with pancreatic and liver cancers.  He completed a research fellowship in Cancer Immunology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins investigating the role of immune therapy in patients with metastatic liver disease. His surgical oncology fellowship at Memorial Sloan-Kettering Cancer Center in New York was focused in advanced Hepatopancreatobiliary Surgery where he was also certified to perform robotic cancer operations.

He is a member of a talented team of surgeons and oncologists at OHSU where he uses his experience and research to help advance the treatment of patients with cancers of the liver, bile ducts, and pancreas.  He is a member of the OHSU Knight Cancer Institute and of the Southwest Oncology Group, which offers patients the latest in cancer care through participation in clinical trials. His research at OHSU involves using hepatic arterial regional therapy for patients with liver and bile duct cancers and investigating how to harness the immune system to fight cancer. Specifically, his research efforts are directed toward the early detection of recurrent cancer and monitoring responses to treatment in patients with colorectal cancer metastatic to the liver.

Dr. Mayo views it as a privilege to work with patients, their families, and primary care doctors to develop the best treatment plans. He is dedicated to offering the highest quality of service. He looks forward to working with other cancer specialists to help give his patients the most options and the best possible outcome.

Read more


  • English

Memberships and associations

  • Society of Surgical Oncology (SSO)
  • Americas Hepato Pancreato Biliary Association (AHPBA)
  • American Society of Clinical Oncology (ASCO)
  • Connective Tissue Oncology Society (CTOS, Sarcoma)
  • American Association of Cancer Research (AACR)
  • Johns Hopkins Surgery, Old Hands Club
  • American College of Surgeons
  • North Pacific Surgical Association
  • Portland Surgical Society
  • Mackenzie Surgical Society
  • Alpha Omega Alpha (AOA) Medical Honor Society
  • SWOG (Southwest Oncology Group) Surgery and Gastrointestinal Oncology Committee Member
  • Trans Atlantic Retroperitoneal Sarcoma Working Group (TARPSWG), Member

Patient Ratings

4.8 out of 5 (233 Ratings, 77 Comments)

The patient ratings score is an average of all responses to the question "How likely would you be to recommend this provider to your family and friends (on a scale of 0 to 10)" on our nationally-recognized NRC patient surveys.

Patient Comments

  • Oct 17, 2019

    All aspects of ohsu service, from parking attendant to surgeon, are exempalry!

  • Oct 04, 2019

    Dr. Mayo is always polite, transparent, and prepared. I enjoy his demaenor and teaching.

  • Sep 28, 2019

    They are an excellent team for treatment, a 10.

  • Sep 26, 2019

    Very pleased after first visit with Dr. Mayo

  • Sep 20, 2019

    Excellent, Great team effort to explain proceedings, to make me comfortable. Great efforts to solve the health problem. Thanks

  • Sep 12, 2019

    Outstanding surgeon with a great staff.

  • Sep 05, 2019

    He, and his associate, were very thorough and explained everything to me in a kind, compassionate manner.

  • Sep 05, 2019

    He performed surgery to remove a pelvic mass and my life has improved dramatically ever since. I am very grateful.

  • Sep 05, 2019

    Great doctor and staff. Would like to be able to spend more time in conversations to gain more information as to my case.

  • Aug 22, 2019

    All staff was very courteous and friendly very warm.

  • Aug 09, 2019

    Respect Dr Mayo and his opinions

  • Aug 08, 2019

    He saved my life and has taken care of me as if I were a friend.

  • Aug 08, 2019

    Everyone I had contact with is so compassionate and caring. The doctors exude confidence.

  • Aug 08, 2019

    This provider and hospital provide the best service available in Oregon.

  • Jul 26, 2019

    Great Dr. and staff.

  • Jul 25, 2019

    Dr. Mayo is fantastic. Attentive, listens, explains.

  • Jul 06, 2019

    I was very impressed with Dr. Mayo and the other doctor that was in the room with us. So I would recommend to him anytime. I feel very confident in what he told me so and that's about it. Thank you.

  • Jun 28, 2019

    I'm extremely happy with my care from Dr. Mayo. He's extremely thoughtful and caring, easy to understand, he explain things well. He knows what he's talking about and I just always come away feeling like I don't have questions because he's... he offers a lot of information and always answers my questions and I always feel well cared for and appreciate all his knowledge and input and wonderful personality as well.

  • Jun 27, 2019

    Very organized and such pleasant people from the admission clerks to the Doctors

  • Jun 13, 2019

    1st visit. First impressions very favorable.

  • Jun 13, 2019

    Dr. Mayo and his team are incredibly professional and knowledgeable with excellent "bedside manner". I am extremely confident and trust that they are indeed the best team available to not only perform the anticipated procedure but follow through with the appropriate treatment to give me the very best chance at a cure.

  • Jun 06, 2019

    Dr. Mayo and staff are great. They were on time and were interested in my well being. I feel that are invested in a positive outcome for me. I enjoy meeting the new visiting Doctors.

  • May 31, 2019

    Everything went smooth to getting checked in and seeing my wonderful doctors

  • May 23, 2019

    I?m very satisfied. Dr Mayo took the time to talk to me as a person not a number. Explained all options and his recommendations. Not hurried to get me out of there. Thanks

  • May 11, 2019

    He explains thing well, and is quick to answer questions

  • May 11, 2019

    Hey Dr. Skye Mayo was absolutely amazing. It's kind of a crummy circumstance I had to go see him, but he did a very good job. I would definitely recommend him.

  • May 11, 2019

    Dr. Mayo, it's very nice and kind and Did a good job explain things? And I got moved onto a different doctor even though yet give me bad news and he's kind of going to kind of keep an eye on my case, but I'll be moved on to another doctor. I don't know when that will be. I'm hoping it'll be soon. But Dr. Mayo was nice and kind of cleaning things. Anyway, thank you.

  • May 04, 2019

    Both Dr. Mayo and Dr. Pasko are quite lovely and always make sure I feel heard and seen. I know they care about me.

  • Apr 25, 2019

    It didn't go as I wanted it to, but I understand his reasoning

  • Apr 18, 2019

    Dr Mayo is amazing. He is informative, caring, very thorough and compassionate. I always leave knowing I’m in the best hands with him.

  • Apr 18, 2019

    Dr. Skye and staff are amazing in every way. I feel like royalty every visit and or interaction with them. They are a blessing to us.

  • Apr 12, 2019

    My visit with Dr Mayo was outstanding, getting great news that my cancer is gone. Dr Mayo and his Team are fabulous.My experience with OHSU and OHHU has been the best care I could ever have. Thank you Thank You Thank you

  • Apr 11, 2019

    We love him. He’s thorough and covers all the information to make sure you understand. For a surgeon he has a wonderful bedside manner. I have no complaints against him or any of his staff. They are all great,

  • Apr 04, 2019

    Dr Mayo explains everything thoroughly and made sure we understood exactly what procedures were going to take place. He never made us feel rushed, and even checked back in on us as we were waiting for his assistant to come speak with us about the surgery.

  • Apr 01, 2019

    Excellent care

  • Mar 15, 2019

    Very caring communicative and competent physician and staff

  • Mar 05, 2019

    Dr Mayo and his team have addressed my concerns and helped me to understand the procedure to be performed. I have confidence in his expertise and skill.

  • Feb 16, 2019

    I was treated... in a friendly, timely, and courteous manner, and... all the providers seemed to be very... knowledgeable, and informed me very well about my situation.

  • Feb 08, 2019

    I felt very confident with him and his...I don't know whether she's another intern or just another doctor that he had with him. I thought they were both very professional and...and very interested my process and were making sure that I got the best care so I was very happy with it.

  • Feb 02, 2019

    Upfront, gentle, kind, realistic. Honest

  • Jan 31, 2019

    Prompt, courteous, and efficient

  • Jan 25, 2019

    Very competent and compassionate

  • Dec 31, 2018

    Dr. Mayo, Rachel and The Whole Team are Amazing in every way! I am forever Grateful for their Care of me!! Thank you!

  • Dec 29, 2018

    He was informative and honest

  • Dec 28, 2018

    My surgical oncologist is Dr. Skye Mayo. Dr. Mayo is the best doctor I have ever had. He is communicative and compassionate. He and his staff (special kudos to [Name] have made my journey much easier to bear.

  • Dec 28, 2018

    Dr Mayo is thorough, considerate and informative. He is careful to go through all the information and answer any questions I might have. His confidence makes me feel like I'm in very good hands.

  • Dec 27, 2018

    One of the best. He is a person who truly cares about his patients.

  • Dec 22, 2018

    He's a very good doctor, caring, he's passionate about his work, and he's always there for you, and he does a great job.

  • Dec 21, 2018

    Good communicator and compassionate care giver. Has great staff around him

  • Dec 21, 2018

    Great personal attention. Caring. Pro-active.Informed. Action plan.