Our lab focuses on the integration of biological and behavioral (a.k.a. biobehavioral) markers to improve patient-reported outcomes for adults living with heart failure specifically and those living with cardiovascular disease more broadly. We are currently pursuing two angles: physical frailty and symptoms among adults with heart failure (including mechanisms, outcomes, and sex/gender differences therein). Our research is primarily funded by the National Institutes of Health along with other foundations. Check out our team, on-going projects, publications, and more below!
Quin Denfeld, PhD, RN, FAHA
A lifelong Oregonian, I graduated from Hillsboro High School (proud Spartan!) followed by Linfield College where I majored in nursing and minored in biology. I worked as a critical care nurse in the Cardiac and Surgical Intensive Care Unit at OHSU where I developed the “research bug,” and thus, I decided to pursue a PhD. I trained with Dr. Christopher Lee at OHSU School of Nursing for my PhD studies, graduating in 2016. I completed a post-doctoral fellowship in cardiovascular medicine at OHSU School of Medicine, training with Dr. Beth Habecker. I came back to the School of Nursing for a faculty position, where I now focus on research, teaching in the PhD program, and providing service to multiple professional organizations such as the American Heart Association and the Heart Failure Society of America. I am also an Associate Editor for the European Journal of Cardiovascular Nursing and an Editorial Board member for the Journal of Cardiac Failure. At home, I’m surrounded by my husband, three boys, a dog, and acres of hazelnut and walnut trees where I attempt to carve out time for my hobbies: running, reading, travel, and enjoying wine and beer.
Shirin Hiatt, MPH, MS, RN (she, her)
Senior Research Associate/Study Coordinator
I am a senior research associate at Oregon Health & Science University (OHSU) School of Nursing. I have worked at OHSU School of Nursing for over 25 years as a researcher and instructor. I have extensive research management experience and have overseen numerous federally funded studies across various chronic illnesses including cancer, dementia, heart failure and liver disease throughout my career.
I have lived in Oregon since 1985. I earned a bachelor’s degree in mathematics from University of Oregon. Later, I completed my bachelor’s degree in nursing at OHSU, followed by dual master’s degrees in nursing and public health, specializing in epidemiology and biostatistics. Currently, I am a PhD student at University of Utah College of Nursing as well as pursuing a graduate certificate in gerontology through the Gerontology Interdisciplinary Program. My research interests are in family caregiving and dyadic research across the adult life span, specifically around dyadic appraisal of priorities and self-management in complex care needs of patients with multimorbidity and their informal/family caregivers. I am particularly interested in patient-caregiver congruence on priorities of care and how that relates to self-management of multimorbidity complex care and affects dyads’ wellbeing.
When not working, I study! I also love spending time with my family, reading for fun, watching movies, cooking, and travelling when I can.
Mary Roberts Davis, BSN, RN, PhD Candidate
Research Assistant/Graduate Student
I am a nurse finishing up my PhD in Nursing with a focus on cardiovascular disease and associations with reproductive history in women. As a Native Oregonian, I have lived in Astoria, Eugene, and Portland. I graduated from the University of Portland and worked as a critical care nurse until deciding to pursue a PhD in 2018. I have been working with Dr. Denfeld’s lab since then - and love interacting with research participants and learning about living with a diagnosis of heart failure. I am an active member in the American Association of Heart Failure Nursing, Heart Failure Society of America, and the American Heart Association. When not working, I enjoy time at home with my family and friends. I love backpacking and spending time at the beach or in the mountains.
Yasmine Robles, BA
I graduated from Western Oregon University in 2021 with a Bachelor of Arts in Psychology and a minor in Human Biology. I am most passionate about psychology and neuroscience and am interested in pursuing a career in neuroscience to become a neuroscientist. Along with being a Research Assistant in the Denfeld Lab, I am also a Clinical Research Associate (CRA) at the Northwest Psychometric Research Institute (NPRI) in Portland, Oregon, where I am able to work with Clinical and Forensic Psychologist, Dr. Robert B. Basham. As a CRA at NPRI, I have the opportunity to study childhood psychological trauma and how it affects future parenting skills among adults with parental difficulties. In the Denfeld lab, I am most responsible for collecting data which includes visiting current study participants at the OHSU hospital and OHSU Beaverton Primary Care Clinic. As both an RA and CRA, it has been a pleasure working with a wonderful team of researchers to establish greater changes in health care research. When not in the lab, I enjoy reading, visiting Oregon’s beautiful beaches, traveling among Mexico’s coastlines, and dancing to any rhythm that warms my soul.
Daniela Cramer, BA
I was born in Lima, Peru. I lived in Maryland before attending Portland State University where I graduated with a double major in Applied Linguistics and Spanish. I tutored for native Spanish speakers and also mentored in an Intensive English Language Program during most of my time at PSU. Language and culture are my deep interests. I’m planning on pursuing an MPH, hopefully I can address issues that language and culture create in a health care setting, while implementing new ways in how to integrate non-English speakers into a health care culture that they might not be familiar with. I’ve been working at the Denfeld lab translating documents, creating new material in Spanish and helping with participants. I’m also part of the Oregon Health Care Interpreters Association since 2017 where I became aware of the discrepancies non-English speakers have. I also love making postcards, birthday cards, and walking my dog Bruce in my free time.
Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure (BIOMES-HF)
Funding: National Institutes of Health/National Institute of Nursing Research (R01NR019054; PI: Denfeld; Dates: 4/23/21-1/31-25)
The purpose of this study to 1) identify clusters of change in symptoms after a heart failure hospitalization and 2) quantify longitudinal associations between symptoms, biomarkers, and physical frailty.
We are currently enrolling for this study: firstname.lastname@example.org
- Denfeld, Q.E., Camacho, S.A., Dieckmann, N., Hiatt, S.O., Davis, M.R., Cramer, D.V., Rupert, A., Habecker, B.A., & Lee, C.S. (2022) Background and design of the Biological and Physiological Mechanisms of Symptom Clusters in Heart Failure (BIOMES-HF) study. J Card Fail (in press) PMID: 35045322
Applying Proteomics to Identify Biomarkers and Profiles of Physical Frailty in Heart Failure (PRO-FRAIL-HF)
Funding: Medical Research Foundation (PI: Denfeld; Dates: 8/1/20-7/31/22)
The purpose of this study is to identify biomarkers and biobehavioral profiles of physical frailty in heart failure.
We are collaborating with the Pacific Northwest National Laboratory to complete this work.
Gender-Associated Differences in Physical Frailty Phenotypes in Heart Failure (GAP-FRAIL-HF)
Funding: National Institutes of Health/Office of Research in Women’s Health (K12HD043488; PI: Denfeld; Dates: 10/1/17-9/30/20)
The purpose of this study was to elucidate gender differences in physical frailty in heart failure as a function of biological and physiological mechanisms and in terms of clinical and patient-reported outcomes.
- Women are more physically frail compared with men in heart failure
- Physical frailty in both women and men is characterized by comorbidities and worse symptoms
- Physical frailty in men is characterized by worse physiological characteristics
- Denfeld, Q.E., Habecker, B.A., Camacho, S.A., Davis, M.R., Gupta, N., Hiatt, S.O., Medysky, M., Purnell, J.Q., Winters-Stone, K., & Lee, C.S. (2021) Characterizing sex differences in physical frailty phenotypes in heart failure. Circ: Heart Fail, 14(9):e008076 PMID: 34428925; PMCID: PMC8458254
- Denfeld, Q.E., Lee, C.S., & Habecker, B.A. (2022) A primer on incorporating sex as a biological variable into the conduct and reporting of basic and clinical research studies Am J Physiol Heart Circ (in press) PMID: 35050071
Check out Dr. Denfeld’s podcast episode through the American Journal of Physiology-Heart & Circulatory Physiology on incorporating sex as a biological variable into research studies.