Doernbecher Children's Hospital

Davare Lab Members

Group photo of Davare Lab Members

Nicolle Hofmann, Ph.D.

Nicolle Hofmann

Senior Research Assistant
hofmannn@ohsu.edu

Nicolle grew up in the Midwest, Urbana-Champaign, Illinois and attended the University of Illinois at Urbana-Champaign. She obtained a bachelors in Animal Sciences and then spent 2 years as a Research Assistant in the Food Science Department studying the metabolism and absorption of carotenoids using animal models. She then started graduate school at the University of Illinois and obtained a Master's of Science in the college of Horticulture and Ph.D. in Natural Resources and Environmental Sciences. Nicolle's graduate research included optimizing somatic embryogenesis in soybean for use in transformation assays. She then moved to plant breeding and genetics to look for genetic markers associated with resistance to diseases in turf grass. After 2 postdoctoral assignments out East, one at the USDA and the other at Virginia Tech University, Nicolle moved to the Pacific Northwest and started working in the Pediatric Cancer Biology Program at OHSU. Originally getting started in cancer research studying Osteosarcoma and currently working in the Davare lab to assist in multiple ways looking at receptor tyrosine kinases and their involvement in oncogenesis and response to possible therapies.

Erin Aguero, B.S.

Erin Aguero, B.S.

Research Assistant 2
aguero@ohsu.edu

Erin was born and raised in Anchorage, Alaska. She graduated from the Honors College at Washington State University with a Bachelor of Science in General Studies of Biological Sciences with an emphasis in Genetics and Cell Biology, and minors in Pre-Genetic Counseling and Spanish Language. After graduation, she provided prevention education to thousands of middle and high school students in health classrooms throughout Clackamas County as a Violence Prevention Educator with Clackamas Women's Services, a domestic and sexual violence crisis center. Erin has also served as a member of the Oregon Attorney General's Sexual Assault Task Force Prevention Education Committee, working to coordinate statewide prevention education efforts. During her undergraduate studies, she started her research career in Dr. William B. Davis's lab investigating how the histone H2A-H2B acidic patch is involved in DNA repair pathways. Her Honors Thesis, Targeting ATR as a Therapy for Ovarian Cancer, was a literature review that explored her growing interest in the use of targeted kinase inhibitors for the treatment of cancers. Currently, she is working to characterize various mutants of the orphan receptor tyrosine kinase ROS1 and their involvement in oncogenesis and response to targeted therapy.

Sudarshan Iyer, B.S.E.

Sudarshan Iyer, B.S.E.

M.D./Ph.D. Student
iyesu@ohsu.edu

Originally from Phoenix, Arizona, Sudarshan completed a B.S.E in Biomedical Engineering at Arizona State University in 2015. During that time he was a volunteer researcher at Barrow Neurological Institute under the guidance of Dr. Neil Crawford and worked to develop patient-specific surgical aids and refine a novel spine surgical simulator. He also worked with a neurosurgeon, Dr. Yashar Kalani, to publish unique and complex neurosurgical cases. After graduating from ASU, Sudarshan matriculated into the M.D./Ph.D program at OHSU and is currently working with Dr. Monika Davare to understand aberrant receptor tyrosine kinase signaling and oncogenic fusion proteins in the context of the ROS1 receptor. His hobbies include music (trained vocalist, budding guitarist), cooking and exploring, both locally and internationally.

Adjunct lab members

Kevin Nusser, Ph.D.

Kevin, a member of Dr. Lara Davis's lab, is an adjunct member of the Davare Lab. He is spearheading the project aimed at characterizing the tumor microenvironment of pediatric brain tumors.

Jon Savage

Jon, a member of Dr. Shinde's lab, is an adjunct member of the Davarre Lab.
savagjo@ohsu.edu

Alumni

Jacob Henderson, M.D.

Jacob Henderson, M.D.

Pediatric Hematology-Oncology Fellow
Currently - Instructor, Pediatric Hematology-Oncology, OHSU

hendejac@ohsu.edu

Jacob grew up in the beautiful Northwest, born and raised on Whidbey Island in Puget Sound, before he went to Pacific Lutheran University to obtain his bachelors in biology. After college he was accepted into University of Washington School of Medicine where he trained in Alaska, Idaho, rural Washington and Guatemala. Upon graduation from medical school Jacob pursued his pediatrics residency at University of California, Davis where he was retained for an additional year to act as Chief resident. He was then recruited to Doernbecher Children's Hospital at OHSU for his Pediatric Hematology/Oncology fellowship during which he developed an interest in high-risk brain tumors. He was able to pursue this interest under the training of Dr. Monika Davare in his research years of fellowship, during which he studied rare but recurring kinase pathway lesions in high-risk medulloblastoma. Currently Jacob is pursuing post-doctoral research training with Dr. Yoon-Jae Cho, using the skills he learned while in the Davare lab to better understand the role of epigenetics in drug sensitivity in medulloblastomas and high-grade gliomas. When not in the lab Jacob loves to spend time with his wife and daughter, ideally on the beaches of the Northwest or the trails of the Cascades.

Anna Pickering, Ph.D.

Anna Pickering

Postdoctoral Fellow
Currently –Scientist, Ayumetrix, Inc.

pickeria@ohsu.edu

Anna graduated from Oregon State University in 2011 with a B.S. in Biochemistry and Biophysics and a minor in chemistry, where she began her research career studying lipid pheromones produced by garter snakes. She earned her Ph.D. in Cell and Molecular Biology from the University of Hawaii at Manoa, investigating the role of DNA damage repair mechanisms in diseases such as Fanconi anemia and cancer as well as in drug-induced mitochondrial toxicity in HIV/AIDS patients. Currently, she is working to characterize various fusions of the receptor tyrosine kinase ROS1 and their involvement in oncogenesis and response to therapy.

Summer interns and lab volunteers

Clare Keddy

Clare Keddy

Class of 2019, Lewis & Clark College
Murdock Research Internship Program

Raveena Bhui

Raveena Bhui

Class of 2021, University of Washington
OHSU Cell, Developmental and Cancer Biology Summer Internship Program

Theo Truong

Theo Truong

PGY1 Medical Student, OHSU
Murdock Research Internship Program (2017)