OHSU

Solid Tumors

Scientific Goals

One of the primary goals of the Solid Tumors Program is to conduct studies of novel diagnostics and therapeutic response monitoring, molecular targets and therapies and cancer immunology, through integration of basic, translational and clinical trials integrating specialized cell culture and animal models, translational studies of human tissue, and clinical trials, by leveraging the organizational structure and shared resources of the OHSU Knight Cancer Institute. This includes conducting preclinical investigations, using molecular methods to identify and validate new biomarkers for diagnosis and prognosis, and molecular targets for treatment and prevention of progression. 

FOCUS GROUPS

There are three focus groups within the Solid Tumors Program, each one a dynamic working group that connects members doing basic/translational research to clinical members (through research forums, retreats, and seminar series, journal clubs, training grants) and to specialized research approaches, including pre-clinical (tissue and cell specific cell culture, animal models, target biochemical studies and drug development), human tissue studies (marker evaluation, treatments, imaging advances) and clinical trials (design and implementation).

  1. Diagnostics, Predictors and Therapeutic 
  2. Target Development and Therapeutics
  3. Cancer Immunology and Immunotherapy

Program Leader

Molly F. Kulesz-Martin, Ph.D.  

Program Members

Researcher Research Area

Alumkal, Joshi J., M.D.

Lab Page

Special Expertise:
  • All stages of prostate cancer and other genitourinary malignancies.
 

Amling, Christopher L., M.D., F.A.C.S

Special Expertise:
  • Urologic
  • bladder
  • cancer
  • prostate
  • oncology
 

Beer, Tomasz M., M.D., F.A.C.P.

Special Expertise:
  • calcitriol
  • prostate cancer
 

Billingsley, Kevin G., M.D.

Special Expertise:
  • Surgical oncology
 

Chui, Stephen, M.D.

Special Expertise:
  • Breast Cancer
 

Coakley, Fergus, M.D.

Special Interest:
  • Diagnostic Radiology
 

Corless, Christopher L., M.D., Ph.D.

Special Expertise:
  • GI
 

Duvoisin, Robert M, Ph.D.

Special Interest:
 

Fedorov, Lev, Ph.D.

Lab Page

Appointments:
Transgenic Core Director  

Garzotto, Mark, M.D.

Special Expertise:
  • prostate cancer
 

Gross, Neil D, M.D., F.A.C.S.

Special Expertise:
  • head and neck cancer
  • carcinogenesis
  • novel molecular therapeutics
  • Thyroid and Parathyroid Glands
  • Microsurgery
 

Heinrich, Michael C., M.D.

Lab Page

Special Expertise:
  • malignancies
  • Hematology
 

Hill, Ann, Ph.D.

Appointments:
Associate Professor  

Holland, John M., M.D.

Special Expertise:
  • Head and neck tumors
 

Huang, Wei, Ph.D.

Special Expertise:
  • MR spectroscopy
  • dynamic contrast-enhanced MRI
  • sarcoma
  • MRI
  • breast cancer
 

Hung, Arthur Y., M.D.

Special Interest:
  • Eye Cancer
 

Jacques, Steven L, Ph.D.

Lab Page

Special Expertise:
  • biophotonics
  • tissue optics
  • optical diagnostics
  • biomedical engineering
  • lasers
 

Keller, Charles,

Appointments:
Leader, Pediatric Cancer Biology Program  

Koop, Dennis R, Ph.D.

Lab Page

Special Interest:
 

Kulesz-Martin, Molly F., Ph.D.

Lab Page

Special Expertise:
  • carcinogenesis
  • ubiquitin ligase
  • trim32
  • piasy
  • p73
 

Liskay, R. Michael, Ph.D.

Lab Page

Special Expertise:
  • DNA mismatch repair
  • mouse models
  • genomic instability
  • colon cancer research OHSU
  • colorectal cancer
 

Lopez, Charles D., M.D., Ph.D.

Special Expertise:
  • Tumor biology
 

Luoh, Shiuh-Wen, M.D.

Special Expertise:
  • Breast Cancer
 

Madison, Dana, M.D.,Ph.D.

Special Expertise:
  • Calcium regulation and metabolic bone disease
 

McCarty, Owen J.T., Ph.D.

Appointments:
Assistant Professor, Department of Biomedical Engineering
Assistant Professor, Department of Cell & Development Biology  

Morgans, Catherine W, Ph.D.

Special Interest:
 

Naik, Arpana M., M.D.

Special Expertise:
  • Breast Cancer
 

Naugler, Willscott E., M.D.

Special Expertise:
  • Acute liver failure
 

Neuwelt, Edward A., M.D.

Special Expertise:
  • Blood brain barrier procedure for brain tumor patients.
 

Orloff, Susan L., M.D.

Special Expertise:
  • Hepatobiliary
  • Kidney and Pancreas Transplant
  • Bile Duct Cancer
  • Cysts
  • Tumors
  • Liver
  • Liver Cancer
 

Parker, David, Ph.D.

Lab Page

Special Expertise:
  • cellular immunology
  • lymphocyte activation
  • immunological tolerance
  • immunological synapse
  • intercellular communication
 

Pejovic, Tanja, M.D., Ph.D.

Special Expertise:
  • Ovarian cancer
 

Pike, Martin, Ph.D.

Special Interest:
 

Roberts, Charles T., Ph.D.

Special Expertise:
  • insulin action
  • insulin-like growth factor action
  • prostate cancer
  • metabolic disease
  • diabetes
 

Roselli, Charles, PHD

Lab Page

Appointments:
Professor of Physiology and Pharmacology Professor of Anesthesiology  

Ross, Donald A, M.D.

Special Interest:
  • Neurosurgery
 

Rotwein, Peter, MD

Special Interest:
 

Ryan, Christopher W., M.D.

Special Expertise:
  • Treatment of genitourinary cancers and sarcomas
 

Sheppard, Brett C., M.D.

Special Interests:
  • Digestive Surgery
  • General Surgery
  • Laparoscopic and Endoscopic Surgery
  • Nissen Fundoplication
  • GI Tract - Upper (includes esophagus
  • stomach
  • gallbladder and biliary system)
  • Pancreatic Cancer
 

Springer, Charles,

Special Interest:
 

Stork, Philip J, MD

Lab Page

Special Interest:
 

Streeter, Philip, PHD

Lab Page

Special Interest:
 

Swanson, Neil A., M.D.

Special Expertise:
  • Skin cancer
  • Mohs surgery
  • melanoma
  • melanoma
 

Taylor, Matthew Hiram, M.D.

Special Interest:
  • Thyroid Cancer
 

Thomas, Charles R., Jr., M.D.

Special Interest:
  • Radiation Oncology
 

Thomas, George, M.D.

Appointments:
Associate Professor Director, Pathology Core, OHSU Knight Cancer Institute  

Troxell, Megan, M.D., Ph.D.

Special Expertise:
  • Immunohistochemistry
  • Breast Pathology
  • Renal Pathology
  • Transplantation Pathology
 

Tsikitis, Vassiliki, M.D.

Special Interests:
  • Digestive Surgery
  • Surgery
  • Anal Cancer
  • Colorectal Cancer
  • Cancer Research
 

Vu, Tania, Ph.D.

Lab Page

Appointments:
Faculty member, Center for Spatial Systems Biology
Research member, Knight Cancer Institute
Faculty member, Neuroscience Graduate Program
Leadership Team, Oregon Nanoscience and Microtechnologies- Institute (ONAMI)  

Wax, Mark K., M.D., F.A.C.S., F.R.C.S.

Special Interest:
  • Head and Neck Surgery
 

Wong, Melissa Hirose, Ph.D.

Lab Page

Special Expertise:
  • cancer stem cell
  • intestinal stem cell niche
  • metastatic cancer
  • cell fusion
  • colorectal cancer
 

External Program Members

Researcher Research Area
Bernard Fox, Ph.D.
Providence
Arup Indra, Ph.D. Molecular & Medical Genetics, Shriners
Walter Urba, M.D., Ph.D. Providence
Andrew Weinberg, Ph.D. Molecular Microbiology & Immunology, Providence



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