Since 2011, Dr. Pfeiffer has served as the Hospital Epidemiologist at the VA Portland Health Care System (VAPORHCS) and as an Infectious Diseases (ID) physician, rounding on both General and Transplant ID consult services at VAPORHCS and Oregon Health & Science University (OHSU). In 2012, he began what is a fruitful ongoing collaboration with the Oregon Health Authority (OHA) by becoming the Medical Director for our Drug-Resistant Organism Prevention and Coordinated Regional Epidemiology (DROP-CRE) Network. The primary goals of DROP-CRE Network, which is funded through OHA by CDC, are to prevent, detect, and control the spread of multidrug-resistant organisms (MDROs) with a focus on carbapenem-resistant Enterobacteriaceae (CRE) in Oregon. 

Over the past 5 years, Dr. Pfeiffer has become increasingly involved in multicenter collaborations. He is Principal Investigator of a CDC BAA contract entitled, "Preventing Spread of Carbapenem-Resistant Enterobacteriaciae (CRE) among Veterans through an Automated Tracking System". For this 1-year project which is currently underway, he is implementing a novel electronic system to track patients with multidrug-resistant organisms such as CRE as they are transferred from facility-to-facility across the country at 10 VA medical centers. Also, he serves as a co-investigator for the VA HSR&D-funded CREATE projects as well as a recently completed pulsed xenon technology grant.