Publications

Sorted from newest to oldest

• Levine JA, Oleaga C, Eren M, Amaral AP, Shang M, Lux E, Khan SS, Shah SJ, Omura Y, Pamir N, Hay J, Barish G, Miyata T, Tavori H, Fazio S, Vaughan DE. Role of PAI-1 in hepatic steatosis and dyslipidemia. Sci Rep. 2021 Jan 11;11(1):430. doi: 10.1038/s41598-020-79948-x. PubMed PMID: 33432099; PubMed Central PMCID: PMC7801442.

• Plubell DL, Fenton AM, Rosario S, Bergstrom P, Wilmarth PA, Clark WM, Zakai NA, Quinn JF, Minnier J, Alkayed NJ, Fazio S, Pamir N. High-Density Lipoprotein Carries Markers That Track With Recovery From Stroke. Circ Res. 2020 Oct 23;127(10):1274-1287. doi: 10.1161/CIRCRESAHA.120.316526. Epub 2020 Aug 26. PubMed PMID: 32844720; PubMed Central PMCID: PMC7581542.

• Pamir N, Fazio S. Lipoprotein(a) Gets Worse. Circ Res. 2020 May 8;126(10):1360-1362. doi: 10.1161/CIRCRESAHA.120.316980. Epub 2020 May 7. PubMed PMID: 32379575; PubMed Central PMCID: PMC7252907.

• Robino JJ, Pamir N, Rosario S, Crawford LB, Burwitz BJ, Roberts CT Jr, Kurre P, Varlamov O. Spatial and biochemical interactions between bone marrow adipose tissue and hematopoietic stem and progenitor cells in rhesus macaques. Bone. 2020 Apr;133:115248. doi: 10.1016/j.bone.2020.115248. Epub 2020 Jan 20. PubMed PMID: 31972314; PubMed Central PMCID: PMC7085416.

• Cheng J, Cheng A, Clifford BL, Wu X, Hedin U, Maegdefessel L, Pamir N, Sallam T, Tarling EJ, de Aguiar Vallim TQ. MicroRNA-144 Silencing Protects Against Atherosclerosis in Male, but Not Female Mice. Arterioscler Thromb Vasc Biol. 2020 Feb;40(2):412-425. doi: 10.1161/ATVBAHA.119.313633. Epub 2019 Dec 19. PubMed PMID: 31852219; PubMed Central PMCID: PMC7018399.

• Tavori H, Fenton AM, Plubell DL, Rosario S, Yerkes E, Gasik R, Miles J, Bergstrom P, Minnier J, Fazio S, Pamir N. Elevated Lipoprotein(a) Levels Lower ABCA1 Cholesterol Efflux Capacity. J Clin Endocrinol Metab. 2019 Oct 1;104(10):4793-4803. doi: 10.1210/jc.2018-02708. PubMed PMID: 31220285; PubMed Central PMCID: PMC6735736.

• Pamir N, Pan C, Plubell DL, Hutchins PM, Tang C, Wimberger J, Irwin A, Vallim TQA, Heinecke JW, Lusis AJ. Genetic control of the mouse HDL proteome defines HDL traits, function, and heterogeneity. J Lipid Res. 2019 Mar;60(3):594-608. doi: 10.1194/jlr.M090555. Epub 2019 Jan 8. PubMed PMID: 30622162; PubMed Central PMCID: PMC6399512.

• Fazio S, Shapiro MD. Medication-based versus target-based lipid management. J Diabetes. 2018 Oct;10(10):789-792. doi: 10.1111/1753-0407.12789. Epub 2018 Jul 2. PubMed PMID: 29962061; PubMed Central PMCID: PMC7252911.

• Plubell DL, Fenton AM, Wilmarth PA, Bergstrom P, Zhao Y, Minnier J, Heinecke JW, Yang X, Pamir N. GM-CSF driven myeloid cells in adipose tissue link weight gain and insulin resistance via formation of 2-aminoadipate. Sci Rep. 2018 Jul 31;8(1):11485. doi: 10.1038/s41598-018-29250-8. PubMed PMID: 30065264; PubMed Central PMCID: PMC6068153.

• Gutiérrez OM, Irvin MR, Chaudhary NS, Cushman M, Zakai NA, David VA, Limou S, Pamir N, Reiner AP, Naik RP, Sale MM, Safford MM, Hyacinth HI, Judd SE, Kopp JB, Winkler CA. APOL1 Nephropathy Risk Variants and Incident Cardiovascular Disease Events in Community-Dwelling Black Adults. Circ Genom Precis Med. 2018 Jun;11(6):e002098. doi: 10.1161/CIRCGEN.117.002098. PubMed PMID: 29899045; PubMed Central PMCID: PMC6339526.

• Shapiro MD, Tavori H, Fazio S. PCSK9: From Basic Science Discoveries to Clinical Trials. Circ Res. 2018 May 11;122(10):1420-1438. doi: 10.1161/CIRCRESAHA.118.311227. Review. PubMed PMID: 29748367; PubMed Central PMCID: PMC5976255.

• Pamir N, Hutchins PM, Ronsein GE, Wei H, Tang C, Das R, Vaisar T, Plow E, Schuster V, Koschinsky ML, Reardon CA, Weinberg R, Dichek DA, Marcovina S, Getz GS, Heinecke JW. Plasminogen promotes cholesterol efflux by the ABCA1 pathway. JCI Insight. 2017 Aug 3;2(15). doi: 10.1172/jci.insight.92176. eCollection 2017 Aug 3. PubMed PMID: 28768900; PubMed Central PMCID: PMC5543924.

• Plubell DL, Wilmarth PA, Zhao Y, Fenton AM, Minnier J, Reddy AP, Klimek J, Yang X, David LL, Pamir N. Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. Mol Cell Proteomics. 2017 May;16(5):873-890. doi: 10.1074/mcp.M116.065524. Epub 2017 Mar 21. PubMed PMID: 28325852; PubMed Central PMCID: PMC5417827.

• Norata GD, Tavori H, Pirillo A, Fazio S, Catapano AL. Biology of proprotein convertase subtilisin kexin 9: beyond low-density lipoprotein cholesterol lowering. Cardiovasc Res. 2016 Oct;112(1):429-42. doi: 10.1093/cvr/cvw194. Epub 2016 Aug 5. Review. PubMed PMID: 27496869; PubMed Central PMCID: PMC5031950.

• Fazio S, Pamir N. HDL Particle Size and Functional Heterogeneity. Circ Res. 2016 Sep 2;119(6):704-7. doi: 10.1161/CIRCRESAHA.116.309506. PubMed PMID: 27587407; PubMed Central PMCID: PMC5971193.

• Zhu L, Giunzioni I, Tavori H, Covarrubias R, Ding L, Zhang Y, Ormseth M, Major AS, Stafford JM, Linton MF, Fazio S. Loss of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 Confers Resistance to the Antiatherogenic Effects of Tumor Necrosis Factor-α Inhibition. Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1483-95. doi: 10.1161/ATVBAHA.116.307736. Epub 2016 Jun 30. PubMed PMID: 27365402; PubMed Central PMCID: PMC5346022.

• Tavori H, Christian D, Minnier J, Plubell D, Shapiro MD, Yeang C, Giunzioni I, Croyal M, Duell PB, Lambert G, Tsimikas S, Fazio S. PCSK9 Association With Lipoprotein(a). Circ Res. 2016 Jun 24;119(1):29-35. doi: 10.1161/CIRCRESAHA.116.308811. Epub 2016 Apr 27. PubMed PMID: 27121620; PubMed Central PMCID: PMC4920709.

• Tavori H, Giunzioni I, Predazzi IM, Plubell D, Shivinsky A, Miles J, Devay RM, Liang H, Rashid S, Linton MF, Fazio S. Human PCSK9 promotes hepatic lipogenesis and atherosclerosis development via apoE- and LDLR-mediated mechanisms. Cardiovasc Res. 2016 May 15;110(2):268-78. doi: 10.1093/cvr/cvw053. Epub 2016 Mar 15. PubMed PMID: 26980204; PubMed Central PMCID: PMC4836631.

• Pamir N, Hutchins P, Ronsein G, Vaisar T, Reardon CA, Getz GS, Lusis AJ, Heinecke JW. Proteomic analysis of HDL from inbred mouse strains implicates APOE associated with HDL in reduced cholesterol efflux capacity via the ABCA1 pathway. J Lipid Res. 2016 Feb;57(2):246-57. doi: 10.1194/jlr.M063701. Epub 2015 Dec 15. PubMed PMID: 26673204; PubMed Central PMCID: PMC4727420.

• Giunzioni I, Tavori H, Covarrubias R, Major AS, Ding L, Zhang Y, DeVay RM, Hong L, Fan D, Predazzi IM, Rashid S, Linton MF, Fazio S. Local effects of human PCSK9 on the atherosclerotic lesion. J Pathol. 2016 Jan;238(1):52-62. doi: 10.1002/path.4630. Epub 2015 Nov 13. PubMed PMID: 26333678; PubMed Central PMCID: PMC5346023.

• Pamir N, Liu NC, Irwin A, Becker L, Peng Y, Ronsein GE, Bornfeldt KE, Duffield JS, Heinecke JW. Granulocyte/Macrophage Colony-stimulating Factor-dependent Dendritic Cells Restrain Lean Adipose Tissue Expansion. J Biol Chem. 2015 Jun 5;290(23):14656-67. doi: 10.1074/jbc.M115.645820. Epub 2015 Apr 30. PubMed PMID: 25931125; PubMed Central PMCID: PMC4505532.

• Ronsein GE, Pamir N, von Haller PD, Kim DS, Oda MN, Jarvik GP, Vaisar T, Heinecke JW. Parallel reaction monitoring (PRM) and selected reaction monitoring (SRM) exhibit comparable linearity, dynamic range and precision for targeted quantitative HDL proteomics. J Proteomics. 2015 Jan 15;113:388-99. doi: 10.1016/j.jprot.2014.10.017. Epub 2014 Oct 31. PubMed PMID: 25449833; PubMed Central PMCID: PMC4259393.

• Hutchins PM, Ronsein GE, Monette JS, Pamir N, Wimberger J, He Y, Anantharamaiah GM, Kim DS, Ranchalis JE, Jarvik GP, Vaisar T, Heinecke JW. Quantification of HDL particle concentration by calibrated ion mobility analysis. Clin Chem. 2014 Nov;60(11):1393-401. doi: 10.1373/clinchem.2014.228114. Epub 2014 Sep 15. PubMed PMID: 25225166; PubMed Central PMCID: PMC4324763.

• Lee JT, Pamir N, Liu NC, Kirk EA, Averill MM, Becker L, Larson I, Hagman DK, Foster-Schubert KE, van Yserloo B, Bornfeldt KE, LeBoeuf RC, Kratz M, Heinecke JW. Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase. Endocrinology. 2014 Sep;155(9):3409-20. doi: 10.1210/en.2014-1037. Epub 2014 Jun 10. PubMed PMID: 24914938; PubMed Central PMCID: PMC4138576.

• Pamir N, McMillen TS, Edgel KA, Kim F, LeBoeuf RC. Deficiency of lymphotoxin-α does not exacerbate high-fat diet-induced obesity but does enhance inflammation in mice. Am J Physiol Endocrinol Metab. 2012 Apr 15;302(8):E961-71. doi: 10.1152/ajpendo.00447.2011. Epub 2012 Feb 7. PubMed PMID: 22318945; PubMed Central PMCID: PMC3330720.

• Edgel KA, McMillen TS, Wei H, Pamir N, Houston BA, Caldwell MT, Mai PO, Oram JF, Tang C, Leboeuf RC. Obesity and weight loss result in increased adipose tissue ABCG1 expression in db/db mice. Biochim Biophys Acta. 2012 Mar;1821(3):425-34. doi: 10.1016/j.bbalip.2011.11.012. Epub 2011 Dec 10. PubMed PMID: 22179025; PubMed Central PMCID: PMC3293702.

• Pamir N, McMillen TS, Kaiyala KJ, Schwartz MW, LeBoeuf RC. Receptors for tumor necrosis factor-alpha play a protective role against obesity and alter adipose tissue macrophage status. Endocrinology. 2009 Sep;150(9):4124-34. doi: 10.1210/en.2009-0137. Epub 2009 May 28. PubMed PMID: 19477937; PubMed Central PMCID: PMC2736076.

• Pamir N, McMillen TS, Li YI, Lai CM, Wong H, LeBoeuf RC. Overexpression of apolipoprotein A5 in mice is not protective against body weight gain and aberrant glucose homeostasis. Metabolism. 2009 Apr;58(4):560-7. doi: 10.1016/j.metabol.2008.11.018. PubMed PMID: 19303979; PubMed Central PMCID: PMC2689095.

• Pamir N, Lynn FC, Buchan AM, Ehses J, Hinke SA, Pospisilik JA, Miyawaki K, Yamada Y, Seino Y, McIntosh CH, Pederson RA. Glucose-dependent insulinotropic polypeptide receptor null mice exhibit compensatory changes in the enteroinsular axis. Am J Physiol Endocrinol Metab. 2003 May;284(5):E931-9. doi: 10.1152/ajpendo.00270.2002. Epub 2003 Jan 21. PubMed PMID: 12540373.

• Pospisilik JA, Martin J, Doty T, Ehses JA, Pamir N, Lynn FC, Piteau S, Demuth HU, McIntosh CH, Pederson RA. Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats. Diabetes. 2003 Mar;52(3):741-50. doi: 10.2337/diabetes.52.3.741. PubMed PMID: 12606516.

• Lynn FC, Thompson SA, Pospisilik JA, Ehses JA, Hinke SA, Pamir N, McIntosh CH, Pederson RA. A novel pathway for regulation of glucose-dependent insulinotropic polypeptide (GIP) receptor expression in beta cells. FASEB J. 2003 Jan;17(1):91-3. doi: 10.1096/fj.02-0243fje. Epub 2002 Nov 15. PubMed PMID: 12475913.

• Hinke SA, Lynn F, Ehses J, Pamir N, Manhart S, Kühn-Wache K, Rosche F, Demuth HU, Pederson RA, McIntosh CH. Glucose-dependent insulinotropic polypeptide (GIP): development of DP IV-resistant analogues with therapeutic potential. Adv Exp Med Biol. 2003;524:293-301. doi: 10.1007/0-306-47920-6_35. PubMed PMID: 12675251.

• Hinke SA, Manhart S, Pamir N, Demuth H, W Gelling R, Pederson RA, McIntosh CH. Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP). Biochim Biophys Acta. 2001 May 5;1547(1):143-55. doi: 10.1016/s0167-4838(01)00181-9. PubMed PMID: 11343800.

• Lynn FC, Pamir N, Ng EH, McIntosh CH, Kieffer TJ, Pederson RA. Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats. Diabetes. 2001 May;50(5):1004-11. doi: 10.2337/diabetes.50.5.1004. PubMed PMID: 11334402.