Division of Cardiothoracic Surgery
Research is a core mission of the Division of Cardiothoracic Surgery at OHSU. Our Division has a longstanding history of innovation in the field of cardiothoracic surgery, dating back to the 1950s when the world's first artificial heart valve was developed and successfully implanted by Dr. Albert Starr at OHSU. That tradition continues to this day through our work in basic science, translational, and clinical research. Research performed by our faculty is aimed at advancing our understanding of cardiovascular disease and improving the treatment of our patients through the development of innovative technologies and devices.
Research performed by the Division of Cardiothoracic Surgery focuses on the following areas:
Cardiovascular system development
This project focuses on the genetic and signaling triggers that guide fetal heart valve and great vessel development, and the potential link between these processes and the development of acquired heart disease in adults.
Our faculty are involved in a broad array of translational research projects that seek to leverage advances in basic science into novel therapeutic approaches. This type of research includes projects in molecular imaging, bioengineered vascular grafts, and coagulation.
Our faculty utilize several large clinical databases, including STS, UNOS, NIS, and INTERMACS, to understand the demographic, clinical, and patient factors that influence outcomes in our patients. This research is then used to propose and test changes in clinical pathways that improve these patient outcomes.
Device and drug development
The Division of Cardiothoracic Surgery is involved in numerous pre-market approval trials of devices and medications in various stages of the development pipeline. Recent and ongoing trials include testing of total artificial heart prototypes, ventricular assist devices, valve repair and replacement devices, stent grafts, and procoagulant agents.
The Division of Cardiothoracic Surgery at OHSU welcomes all interested parties to learn more about opportunities to participate, collaborate, and support research in our Division. Please contact our team at 503-494-7820.
Song HK, Tibayan FA, Kahl EA, Sera VA, Slater MS, Deloughery TG, Scanlan MM. Safety and efficacy of prothrombin complex concentrates for the treatment of coagulopathy following cardiac surgery. Journal of Thoracic and Cardiovascular Surgery. 147(3):1036-40, 2014 March.
Song HK, von Heymann C, Jespersen CM, Karkouti K, Korte W, Levy JH, Ranucci M, Saugstrup T, Sellke FW. Safe application of a restrictive transfusion protocol in moderate-risk patients undergoing cardiac operations. Annals of Thoracic Surgery. 97(5):1630-5, 2014 May.
Song HK, Preiss LR, Maslen CL, Kroner B, Devereux RB, Roman MJ, Holmes KW, Tolunay HE, Desvigne-Nickens P, Asch FM, Milewski RK, Bavaria J, LeMaire, SA. Valve Sparing Aortic Root Replacement in Patients with Marfan Syndrome Enrolled in the National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions. Journal of Heart Valve Disease. 23(3):292-8, 2014 May.
Anderson DEJ, Glynn JJ, Song HK, Hinds MT. Engineering an endothelialized vascular graft: a rational approach to study design in a non-human primate model. PLOS ONE. DOI:10.1371/journal.pone.0115163, 2014 December.
Song HK, Gelow JM, Mudd J, Chien C, Tibayan FA, Hollifield K, Naftel D, Kirklin J. Limited utility of tricuspid valve repair at the time of left ventricular assist device implantation. Annals of Thoracic Surgery. 101, 2168-2175. 2016 June.
Weinsaft JW, Devereux RB, Preiss LR, Feher A, Roman MJ, Basson CT, Geevarghese A, Ravekes W, Dietz HC, Holmes K, Habashi J, Pyeritz RE, Bavaria J, Milewski K, LeMaire SA, Morris S, Milewicz DM, Prakash S, Maslen C, Song HK, Silberbach GM, Shohet RV, McDonnell N, Hendershot T, Eagle KA, Asch FM, on behalf of the GenTAC Registry Investigators. Aortic dissection in patients with genetically mediated aneurysms: incidence and predictors in the GenTAC Registry. JACC. 67(23):2744-54. 2016 June.
Singh S, Sayers S, Walter JS, Thomas DD, Dieter RS, Nee LM, Wurster RD. Hypertrophy of Neurons within Cardiac Ganglia in Human, Canine, and Rat Heart Failure: The Potential Role of Nerve Growth Factor. J Am Heart Assoc, 2:e000210, 2013. http://jaha.ahajournals.org/content/2/4/e000210
Walter JS, Thomas DD, Sayers S, Perez-Tamayo RA, Crish T, Singh S. Respiratory Responses to Stimulation of Abdominal and Upper-thorax Intercostal Muscles using Permaloc Electrodes. JRRD (Journal of Rehabilitation Research and Development) 52:85-96, 2015.
Prevalence and Anatomy of Retroesophageal Major Aortopulmonary Collateral Arteries.Mainwaring RD, Patrick WL, Carrillo SA, Ibrahimye AN, Muralidaran A, Hanley FL.Ann Thorac Surg. 2016 Sep;102(3):877-82. doi: 10.1016/j.athoracsur.2016.03.011. Epub 2016 May 18.2.
Surgical Quality Predicts Length of Stay in Patients with Congenital Heart Disease.Johnson EA, Zubair MM, Armsby LR, Burch GH, Good MK, Lasarev MR, Hohimer AR, Muralidaran A, Langley SM. Pediatr Cardiol. 2016 Mar;37(3):593-600. doi: 10.1007/s00246-015-1319-x. Epub 2016 Jan 7. PMID: 26739006
Heart Failure in Adult Congenital Heart Disease: Nonpharmacologic Treatment Strategies. LeMond L, Mai T, Broberg CS, Muralidaran A, Burchill LJ.Cardiol Clin. 2015 Nov;33(4):589-98, viii-ix. doi: 10.1016/j.ccl.2015.07.004. Epub 2015 Aug 21. Review. PMID: 26471822
High flow velocity through congenital cardiac lesions predicts preoperative platelet dysfunction. Zubair MM, Hohimer AR, Bailly DK, Muralidaran A, Madriago EJ, Zubair MH, Lasarev MR, Langley SM. Ann Thorac Surg. 2015 Apr;99(4):1379-85. doi: 10.1016/j.athoracsur.2014.10.039. Epub 2015 Feb 7. PMID: 25661905
A defined management strategy improves early outcomes after the Fontan procedure: the PORTLAND protocol. Sunstrom RE, Muralidaran A, Gerrah R, Reed RD, Good MK, Armsby LR, Rekito AJ, Zubair MM, Langley SM. Ann Thorac Surg. 2015 Jan;99(1):148-55. doi: 10.1016/j.athoracsur.2014.06.121. Epub 2014 Nov 18. PMID: 25442983
Tiwari S, Raman J, Reddy V, Ghetler A, Tella RP, Han Y, Moon CR, Hoke CD, Bhargava R.Towards Translation of Discrete Frequency Infrared Spectroscopic Imaging for Rapid Digital Histopathology of Clinical Biopsy Samples. Anal Chem. 2016 Oct 18;88(20):10183-10190. PMID:27626947
Dobrilovic N, Raman J, Fingleton JG, Maslow A, Singh AK.Long-Term Outcomes of External Repair as a Rescue Operation for Atrioventricular Groove Disruption. Ann Thorac Surg. 2016 Oct 24. pii: S0003-4975(16)31090-6. doi: 10.1016/j.athoracsur.2016.08.024. [Epub ahead of print].PMID: 27788941
Dobrilovic N, Soukas P, Sadiq I, Goldstein L, Raman J. Early complications of biologic extracellular matrix patch after use for femoral artery repair. J Vasc Surg. 2016 Oct 14. pii: S0741-5214(16)31104-1. doi: 10.1016/j.jvs.2016.07.131. [Epub ahead of print].PMID: 27751739.
Chandrashekar P, Jagannathan R, Talluri K, Raman J. Extra-Cardiac Approach to Functional Mitral Regurgitation –A Cost-effective Approach to Addressing Heart Failure. BMJ Innovations. http://dx.doi.org/10.1136/bmjinnov-2016-000115
Mehra MR, Naka Y, Uriel N, et al. A Fully Magnetically Levitated Circulatory Pump for Advanced Heart Failure. N Engl J Med. 2017 Feb 2;376(5):440-450.
Heatley G, Sood P, Goldstein D, et al. Clinical trial design and rationale of the Multicenter Study of MagLev Technology in Patients Undergoing Mechanical Circulatory Support Therapy With HeartMate 3 (MOMENTUM 3) investigational device exemption clinical study protocol. J Heart Lung Transplant. 2016 Apr;35(4):528-36.
Tibayan FA, Louey S, Jonker S, et al. Increased systolic load causes adverse remodeling of fetal aortic and mitral valves. Am J Physiol Integr Comp Physiol. 2015 Dec 15;309(12):R1490-8.
Sedehi D. Finocchiaro G, Tibayan Y, et al. Long-term outcomes of septal reduction for obstructive hypertrophic cardiomyopathy. J Cardiol. 2015 Jul;66(1):57-62.
Rausch MK, Tibayan FA, Ingels NB, et al. Mechanics of the mitral annulus in chronic ischemic cardiomyopathy. Ann Biomed Eng. 2013 Oct;41(10);2171-80.