Innovation at the OHSU Knight Cardiovascular Institute

2020 Innovations in Cardiovascular Health

KCVI Cardio Innovations 2020 annual report cover image

Download the highlights of our groundbreaking work in 2020 as featured in the Innovations in Cardiovascular Health activity report to learn more about OHSU Knight Cardiovascular Institute’s pursuit of knowledge across the spectrum of cardiovascular health.

We are committed to finding breakthroughs for better health and contributing to science through:

Medtronic intrepid mitral valve. Reproduced with permission of Medtronic, Inc.
Medtronic intrepid mitral valve. Reproduced with permission of Medtronic, Inc.

Patient care, including expanding options for all heart valves by performing the first minimally invasive tricuspid valve replacement in a living person and the first implant of a new mitral valve system.

high-intensity focused ultrasound (HIFU) transducer
Using continuous sound waves, the high-intensity focused ultrasound (HIFU) transducer produces a lesion of 10–12 mm in depth.

Translational research, including discovery into the origins of valve disease before birth and creating a less invasive tool for heart arrhythmias.

chematic illustration of arteriolar smooth muscle tone regulation by GPR39 (green), a dual-ligand receptor activated by 15-HETE (blue triangles) to cause constriction, which can be reversed by 14-15-EET
Schematic illustration of arteriolar smooth muscle tone regulation by GPR39 (green), a dual-ligand receptor activated by 15-HETE (blue triangles) to cause constriction, which can be reversed by 14-15-EET (red circles).

Basic research, including discovering the mechanism of the GPR39 receptor in stroke and vascular dementia and race-based differences in heart disease risk.

We believe that the integration of clinical care and research expands the possibilities of cardiovascular health.

The Knight Cardiovascular Institute is an integrated center for translational research, clinical care, professional training and outreach in all aspects of heart and vascular disease. Areas of innovation include cardiovascular imaging, cardiovascular device design, cardiac surgery and transplantation, and epigenetics - the study of fetal origins of chronic adult diseases.

Under the umbrella of a multi-disciplinary institute, researchers and clinicians collaborate together to bring the latest knowledge and cutting edge care to our patients, including:

  • A national leader in studying the developmental origins of disease, such as how certain factors in the prenatal environment can make people more susceptible to heart disease and obesity, our experts work towards understanding the origins of cardiovascular disease and providing tailored treatment
  • Sanjiv Kaul, M.D., developer of the powerful microbubble-based myocardial contrast echocardiography (MCE) technique, directs the West coast's only program that uses microbubble technology to detect early heart attacks
  • Teams of researchers are identifying the genetic and biochemical underpinnings of heart valve defects, vascular disease, rhythm disorders and other potential targets for drug therapies
  • Scientists across OHSU are identifying biological markers and promising drug candidates for treatment of cardiac and stroke damage

Learn more about research at the Knight Cardiovascular Institute