OHSU Knight Cancer Institute

Microbiome and Esophageal Cancer Progression Study

Microbiome and Esophageal Cancer Progression (MEP) Study at OHSU

Have you had an endoscopy for your digestive problems? You may be able to join the MEP study

Right now, there is no non-invasive screening test  for digestive system diseases. We want to change that.

We aim to reduce the risk of esophageal cancer by finding new risk factors and biomarkers from a saliva test. The test that our research is trying to inform will be cheaper, easier and non-invasive. This could earlier identify gastrointestinal problems, preventing progression and saving lives. 

What does study participation involve?

  • All study tasks can be completed at home or a place of your convenience
  • Consent to participate with a REDCap online portal or in-person meeting
  • Complete questionnaires (approximately 1.5 hours)
  • Collect saliva samples
  • Phone call or email with the study team
  • All information that could identify you will be kept confidential
  • Participants will receive $20 in thanks for participation

Who can participate?

  • Those who have had an endoscopy which found:
    1. Normal results
    2. Barrett’s Esophagus with or without dysplasia
    3. Esophagus cancer
  • Men and women ages 18-89
  • No history of cancer diagnosis (excluding 2 or 3) or cancer treatment, such as radiation, surgery or chemotherapy
  • No oral, intestinal, appendix, or gastroesophageal surgery for 1 month
  • No systemic (non-topical) antibiotics, antifungals, or antivirals for 6 months

Meet our research team

Principal investigator

    • Areas of interest

      • Cancer Prevention and Control Program, OHSU Knight Cancer Institute
      • Programmatic theme: Prevention and Risk Reduction, OHSU Knight Cancer Institute
      • Studying associations between various risk factors and cancer outcomes through working with SEER registries, with a particular interest in cancer prevention through molecular epigenetic modification mechanisms.
      • Epidemiology
      • Cancer Prevention
      • Nutrition and Chemoprevention
      • Microbiome

Co-investigator

Study team

Find out if you are eligible to enroll

Contact a study coordinator to learn more:

Download a study flyer