Heart Rhythm Disease Clinical Trials

The heart rhythm disease clinical trials team is interested in seeing how exciting new heart rhythm drugs and devices can help to improve the outcomes and quality of life for those living with the heart rhythm diseases. 

Feel free to call or e-mail the Knight Cardiovascular Institute research team at 503-418-1964 or by emailing heartresearch@ohsu.edu. You will then be forwarded to the appropriate research team member who will be able to see if you qualify for any of the clinical trials being offered at OHSU. 

You can also find all the of heart failure clinical trials, that are currently enrolling patients, below. 

aCRT-ELSYNC

Adaptive CRT Effect on Electrical Dyssynchrony

Primary investigator:

Larisa Tereshchenko, M.D. Ph.D.

Sub investigators:

Protocol number:

IRB00011299

Study purpose:

The purpose of this study is to better understand how adaptive cardiac resynchronization therapy (aCRT) might benefit patients. aCRT works by sometimes giving stimulation to only the left side of the heart, rather than to both sides, depending on how it senses the heart is functioning. CRT without the adaptive algorithm works by giving stimulation to both sides of the heart. aCRT has already been approved by the FDA and is being used in patients now, but it is not clear which patients it should be used in compared to normal CRT. This study will include patients who are already scheduled to get a CRT device. The investigators will then randomize patients to the aCRT study arm or to the CRT study arm. After 6 months, the investigators will assess the electrical activity of the patients' hearts. After this time, the patient and their doctors will be able to decide if they would like to change the type CRT they have been designated.

Contact:

Nichole Rogovoy (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu 

aMAZE

LEft Atrial Appendage Ligation with the Lariat Suture Delivery System as Adjunctive Therapy to Pulmonary Vein Isolation for Persistent or Long Standing Persistent Atrial Fibrillation.

Primary investigator:

Charles Henrikson, M.D.

Sub investigators:

Protocol number:

IRB00016514

Study purpose:

The study will aim to demonstrate the ability of the LARIAT Suture Delivery System to isolate and ligate the left atrial appendage from the left atrium as an adjunct to planned catheter ablation in the treatment of subjects with symptomatic persistent or longstanding persistent Atrial Fibrillation.

Contact:

Liz Cannard (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu 

ASAP-TOO

Assessment of the WATCHMAN Device in Patients Unsuitable for Oral Anticoagulation

Primary investigator:

Charles Henrikson, M.D.

Sub investigators:

Protocol number:

IRB00017600

Study purpose:

The purpose of this trial is to learn more about the use of a device for atrial fibrillation. 

The intent is to learn how effective the device is and if there are any side effects associated with the study device in patients who cannot tolerate long term oral anticoagulation. 

Contact:

Liz Cannard (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu 

Bipolar Radiofrequency Ablation of Refractory Arrhythmias

Exercise in Genetic Cardiovascular Conditions

Primary investigator:

Babak Nazer, M.D.

Sub investigators:

Protocol number:

IRB00018247

Study purpose:

The purpose of this study is to learn more about a new method of treating ventricular heart rhythm diseases. This trial will work to provide a treatment option for patients in which standard ablation methods were unsuccessful.

Contact:

Liz Cannard (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu 

HCM Pilot Study

Hypertrophic Cardiomyopathy Pilot Study

Primary investigator:

Larisa Tereshchenko, M.D., Ph.D.

Sub investigators:

Protocol number:

IRB00015049

Study purpose:

This study evaluates mechanisms of arrythmogenicity in hypertrophic cardiomyopathy, in comparison to patients with well-understood arrhythmogenic substrate (ischemic cardiomyopathy), as well as to individuals free from arrhythmogenic substrate.

Contact:

Nichole Rogovoy (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu 

LIVE-HCM/LIVE-LQTS

Exercise in Genetic Cardiovascular Conditions

Primary investigator:

Stephen Heitner, M.D.

Sub investigators:

Protocol number:

IRB00012026

Study purpose:

The purpose of this study is to learn about cardiac events in subjects with Hypertrophic Cardiomyopathy and Long QT Syndrome who participate in different levels of activity.

Contact:

Megan Wasteney (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu