Heart Failure Clinical Trials

The heart failure clinical trials team is interested in seeing how exciting new heart failure drugs and devices can help to improve the outcomes and quality of life for those living with the heart failure disease. 

Feel free to call or e-mail the Knight Cardiovascular Institute research team at 503-418-1964 or by emailing heartresearch@ohsu.edu. You will then be forwarded to the appropriate research team member who will be able to see if you qualify for any of the clinical trials being offered at OHSU. 

You can also find all the of heart failure clinical trials, that are currently enrolling patients, below. 

aCRT-ELSYNC

Adaptive CRT Effect on Electrical Dyssynchrony

Primary investigator:

Larisa Tereshchenko, M.D., P.h.D.

Sub investigators:

Protocol number:

IRB00011299

Study purpose:

The purpose of this study is to better understand how adaptive cardiac resynchronization therapy (aCRT) might benefit patients. aCRT works by sometimes giving stimulation to only the left side of the heart, rather than to both sides, depending on how it senses the heart is functioning. CRT without the adaptive algorithm works by giving stimulation to both sides of the heart. aCRT has already been approved by the FDA and is being used in patients now, but it is not clear which patients it should be used in compared to normal CRT. This study will include patients who are already scheduled to get a CRT device. The investigators will then randomize patients to the aCRT study arm or to the CRT study arm. After 6 months, the investigators will assess the electrical activity of the patients' hearts. After this time, the patient and their doctors will be able to decide if they would like to change the type CRT they have been designated.

Contact:

Nichole Rogovoy (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu 

ALt FLOW

Early Feasibility Study of the Edwards Transcatheter Atrial Shunt System

Adaptive CRT Effect on Electrical Dyssynchrony

Primary investigator:

Firas Zahr, M.D.

Sub investigators:

Protocol number:

IRB00018639

Study purpose:

The purpose of the study is to learn about the safety, functionality, and effectiveness of the Edwards Transcatheter Atrial Shunt System in patients with symptomatic left heart failure. 

Contact:

Sarah Fishbein (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu 

HCM Pilot Study

Hypertrophic Cardiomyopathy Pilot Study

Primary investigator:

Larisa Tereshchenko, M.D., Ph.D.

Sub investigators:

Protocol number:

IRB00015049

Study purpose:

This study evaluates mechanisms of arrythmogenicity in hypertrophic cardiomyopathy, in comparison to patients with well-understood arrhythmogenic substrate (ischemic cardiomyopathy), as well as to individuals free from arrhythmogenic substrate.

Contact:

Nichole Rogovoy (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu 

TAVR UNLOAD

Transcatheter Aortic Valve Replacement to Unload the LEft Ventricle in Patients with Advanced Heart Failure: A Randomized Trial (TAVR UNLOAD)

Primary investigator:

Sub investigators:

Protocol number:

IRB00015224

Study purpose:

The purpose of this study is to learn more about treatment for patients with heart failure and moderate aortic valve stenosis with the use of the TAVR System. This study is designed to compare the safety and effectiveness of the TAVR system versus the current standard of care for heart failure patients.

Contact:

Sarah Fishbein (Study Coordinator)
503-418-1964
heartresearch@ohsu.edu