About The Study

Recent advances in genetic testing have uncovered that the first one or two steps toward blood cancer are present in about 10% of older people without evidence of blood cancer.1-4 Aging is a risk factor for acquiring these mutations. The majority of subjects with these findings do not develop blood cancer but some will for unclear reasons. Unexpectedly, the same acquired genetic mutations in blood cells increase the risk for heart disease (heart attacks and strokes) and deaths associated with heart disease.2

These genetic risks may impact a lot of people. Our goal is to study these acquired genetic mutations and to collect data that will help us define the risks for heart disease and blood cancer development more precisely. We hope this study will help us identify those at the highest risk for these often-fatal diseases. With this data, we can then formulate a strategy to intervene before the diseases have fully manifested and potentially improve survival outcomes. We have focused our studies in women because a special test performed on blood samples requires the presence of two X chromosomes.5,6 This special test enhances our ability to identify women who are more likely to carry these acquired genetic mutations in their blood cells.

This study is not associated with a drug treatment at this phase of the study. We are confident that the knowledge gained in this research will apply more broadly to older men and women and improve treatment strategies in the future.

Study participation...

  • Does NOT cost anything to participants
  • Does NOT involve any treatment
  • Requires very little time and effort: participants will fill out an initial health survey, then provide annual health updates and a blood sample (about 2 teaspoons) every 1 to 2 years at study-directed opportunities.


Participants Share Why They Joined the WEAR in Oregon Study

WEAR in Oregon Study Participant

WEAR in Oregon Study Participant

Marcia Johnson: "I'm supporting this study because                      Cheri: "I think it is important to gather information on women's health to better                                     it's an easy way to help other women."                                                  address their gender-specific healthcare issues."

WEAR in Oregon Study Participant

Elaine Kaspar: "I support this study because of the possibility of being able to find                                                                                                                                                           cancer and heart disease before they strike and stop them."