Alzheimer's Disease Research Center

Researcher speaking with colleague, viewing brain scans on computer
Dr. Jeffrey Kaye, Director of the Layton Aging and Alzheimer's Research Center

An Alzheimer's Disease Center

The Layton Aging and Alzheimer's Disease Center is one of the 31 NIA Alzheimer's Disease Centers in the U.S. and the only one of its kind in Oregon. Our center is recognized as a national leader in dementia care and research.

The Administrative Core oversees and sets the research direction for the Layton Center. This Core fosters new and innovative research relevant to brain aging, recruits new investigators, oversees cross-ADC collaborations and multicenter studies, coordinates grant-related activities, and manages financial resources. Working behind-the-scenes, the Administrative Core also acts as a liaison between all the individual Cores and between individual investigators, clinicians, educators and the community.

Director: Dr. Jeffrey Kaye, M.D.

For more information, message Tracy Zitzelberger at zitzelbe@ohsu.edu or call 503-494-7198

The goal of the Clinical Core is to maintain an active group of research participants, with or without dementia, to support a variety of studies. This group includes the underserved African American senior population. Research coordinators screen research participants, perform clinical tests and facilitate clinical trials and studies. The Core also provides data, biological specimens, and expertise to national data sharing initiatives and approved regional and national investigations.

Director: Dr. Jeffrey Kaye, M.D.

For more information, message Dr. Jeffrey Kaye at kaye@ohsu.edu

The Data Management & Statistics Core receives, stores, and manages, and analyzes data generated by the other Cores and by other research projects at the Layton Center. Investigators within this Core provide guidance on statistical analysis, research study design, sample size estimations, interpretation of study findings and related issues. Working collaboratively with the Neuroimaging, Clinical, Biomarker and Neuropathology Cores, this Core shares clinical cohort data with investigators and maintains secure platforms for data exchange.

Director: Dr. Hiroko Dodge, Ph.D.

For more information, message Robin Guariglia at guarigli@ohsu.edu or call 503-494-6977

Learn more about the Center's database, see how to make a data request and view requirements for submitting manuscripts for publication. Read more. 

The Outreach, Recruitment and Education Core develops and manages a wide array of programs to increase public awareness and understanding of Alzheimer's disease and research at the Layton Center. One main goal is building relationships with the community and networking with other organizations to provide educational resources and recruit participants for studies, a particular focus being underserved rural communities, low-income populations and minority groups. The Core also organizes meetings, lectures and workshops throughout Oregon and publishes a newsletter twice a year.

Director: Dr. Allison Lindauer, Ph.D., N.P.

For more information, message Natasha Spoden at spoden@ohsu.edu or call 503-494-6370

Learn about the Layton Center's educational programs for the public and health care professionals. View more.

The Neuropathology Core collects, characterizes, and stores brain donations from clinical study participants at the Oregon Brain Bank, in accordance with established protocols. By creating a safeguarded yet accessible repository of brain tissue and neuropathological data, the Core is able to perform diagnostic evaluations of autopsy tissue and facilitate research about brain aging. The Core provides tissue to investigators researching aging and dementia and teaches trainees about current neuropathological classifications of neurodegenerative diseases.   

Director: Dr. Randall Woltjer, M.D., Ph.D.

For more information about the Oregon Brain Bank, message Dr. Randall Woltjer at woltjerr@ohsu.edu or call 503-494-8276

Learn more about tissue requests and the Core's protocols. View more. 

The Biomarker Core collects and stores tissue samples, biomarkers, family history data and genotype data from subjects recruited by the Clinical Core. (These can include markers in blood, spinal fluid, patterns of activity on MRI scans or scores on cognitive tests). Biomarker data is prepared and distributed to investigators that are a part of ongoing national research studies, in order to foster collaborative research about neurodegenerative disease.  

Director: Dr. Joe Quinn, M.D.

For more information, message Dr. Joe Quinn, M.D. at quinnj@ohsu.edu or call 503-494-7234 

Learn what type of family history and genotype data the Core collects and learn how to request a biomarker data or tissue sample. View more.

The Neuroimaging Core focuses on detecting early brain changes associated with cognitive decline and dementia, using the Neuroimaging Laboratory at the Layton Center. Participants undergo MRI, fMRI and PET scans for a wide array of studies. The Laboratory acts as an archival service, managing a library of thousands of digitized scans and other neuroimaging data. Investigators also receive advanced training in imaging techniques.  

Director: Dr. Lisa Silbert, M.D., M.C.R.

For more information, message David Lahna at lahnad@ohsu.edu or call 503-494-1266 

Learn about the current projects at the Neuroimaging Laboratory. View more.

Grant Opportunities

Pilot and seed funding for research are key to bringing new investigators into the field. Additionally, funding helps established scientists expand the direction of their research. The Layton Center offers several pilot grant programs for new investigators or more experienced investigators who have novel ideas that may advance Alzheimer's research.

Pilot research awards

We have three pilot research awards, the Oregon Alzheimer's Disease Center  (OADC) Pilot Program, the Oregon Roybal Center for Aging and Technology Pilot Program and the Oregon Partnership for Alzheimer's Research (OPAR) grant.

Funds for the OPAR grant have been made available by Oregonians through the Oregon Income Tax Charitable Checkoff Program.

To learn more about these annual awards - including application deadlines, project timelines and how to apply - click on the links.

Neuroimaging Laboratory

The Neuroimaging Lab conducts MRI studies on both 3 and 7T MRI systems using advanced sequences, employing a multimodal approach to brain imaging research.

Explore our Neuroimaging Lab

Alzheimer's Disease Investigator Meeting

This monthly research meeting is held on the third Thursday of the month from 2:30 to 3:30 p.m. at the Layton Aging and Alzheimer's Disease Center, Mark Hatfield Research Center 13th Floor, Room 13D40a.

View our calendar.

Oregon Alzheimer's Disease Center (OADC)

Letter of Intent (LOI) Deadline: November
Application Deadline: December
Project Dates: April 2019 - March 2020
Maximum Direct Costs: $30,000
Number of Awards Given: 2

More information: View or download the grant announcement  

Oregon Roybal Center for Aging and Technology Pilot Program

Letter of Intent (LOI) Deadline: December
Application Deadline: February
Project Dates: June 2019 - May 2020
Maximum Direct Costs: $45,000
Number of Awards Given: 2

More information: View or download the grant announcement  

Oregon Partnership for Alzheimer's Research (OPAR)

Letter of Intent (LOI) Deadline: February
Application Deadline: April
Project Dates: September 2019 - August 2020
Maximum Direct Costs: Up to $20,000
Number of Awards Given: 1-3

More information: