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Vollum Institute at OHSU (OHSU/Kristyna Wentz-Graff)

The Vollum Institute is a privately endowed research institute at Oregon Health & Science University dedicated to basic research that will lead to new treatments for neurological and psychiatric diseases. Vollum scientists have broad-ranging interests that coalesce around molecular neurobiology and cellular physiology. Their work has transformed the field of neuroscience and, in particular, has provided important advances in the study of synaptic transmission, neuronal development, neurotransmitter transporters, ion channels and the neurobiology of disease.
Learn more about the Vollum's mission

Friday Work–In–Progress Talks

The Friday "work-in-progress" (WIP) seminars occur weekly during the academic year and provide an opportunity for postdoctoral fellows and graduate students to share their current research projects in an interactive and less formal environment.
Find out more information on how to attend and the speaker schedule.

PostDoc Career Transition Seminar Series

This week (Dec 1st), the Vollum kicks off the Postdoc Career Transition Seminar Series. This series, which lasts thru February, will highlight the scientific accomplishments and future research plans of OHSU postdocs preparing for careers as independent investigators.

Find out more information and the speaker schedule.

Research highlights

Locomotion activates PKA through dopamine and adenosine in striatal neurons.
Ma L, Day-Cooney J, Benavides OJ, Muniak MA, Qin M, Ding JB, Mao T, Zhong H. Nature. 2022 Nov 9. doi: 10.1038/s41586-022-05407-4. 

Structure of C. elegans TMC-1 complex illuminates auditory mechanosensory transduction 
Jeong, H., Clark, S., Goehring, A., Dehghani-Ghahnaviyeh, S., Tajkhorshid, E., Gouaux, E. (2022) Nature Oct;610: 796-803.

Distinct in vivo dynamics of excitatory synapses onto cortical pyramidal neurons and parvalbumin-positive interneurons
Melander JB*, Nayebi A*, Jongbloets BC, Fortin DA, Maozhen Q, Ganguli S#, Mao T#, Zhong H#.
Cell Reports. 2021 Nov 9;37(6):109972. doi: 10.1016/j.celrep.2021.109972 (*contributed equally) (#co-correspondence)

Glycine Release Is Potentiated by cAMP via EPAC2 and Ca2+ Stores in a Retinal Interneuron
Meadows MA, Balakrishnan V, Wang X, von Gersdorff H.
J Neurosci. 2021 Nov 17;41(46):9503-9520.

Architecture and assembly mechanism of native glycine receptors
Zhu H, Gouaux E
Nature 2021 Sep 23; doi: 10.1038/s41586-021-04022-z
Online ahead of print

Molecular mechanism of prestin electromotive signal amplification
Ge J*, Elferich J*, Dehghani-Ghahnaviyeh S, Zhao Z, Meadows M, von Gersdorff H, Tajkhorshid E, Gouaux E
Cell 2021 Sep 2; 184(18):4669-4679.e13 (*contributed equally)

The residence of synaptically released dopamine on D2 autoreceptors
Condon AF, Robinson BG, Asad N, Dore TM, Tian L, Williams JT
Cell Reports 2021 Aug 3; 36(5):109465

View all in PubMed

Vollum Institute/OHSU scientists identify molecule that could help treat Parkinson’s

Tianyi Mao, Ph.D., and Haining Zhong, Ph.D., are scientists with the OHSU Vollum Institute
Tianyi Mao, Ph.D., and Haining Zhong, Ph.D., are scientists with the OHSU Vollum Institute. The pair's recent discovery of how adenosine operates in the brain is expected to help create new treatments for Parkinson's disease. (OHSU)

Researchers at Oregon Health & Science University have discovered that the neurotransmitter adenosine effectively acts as a brake to dopamine, another well-known neurotransmitter involved in motor control.

Scientists found that adenosine operates in a kind of push-pull dynamic with dopamine in the brain; the new discovery published today in the journal Nature.

“There are two neuronal circuits: one that helps promote action and the other that inhibits action,” said senior author Haining Zhong, Ph.D., scientist with the OHSU Vollum Institute. “Dopamine promotes the first circuit to enable movement, and adenosine is the ‘brake’ that promotes the second circuit and brings balance to the system.”

The discovery could immediately suggest new avenues of drug development to treat symptoms of Parkinson’s disease, a movement disorder where the loss of dopamine-producing cells has been widely implicated as a cause.

Scientists have long suspected that dopamine is influenced by an opposing dynamic of neuronal signaling in the striatum — a critical region of the brain that mediates movement along with reward, motivation and learning. The striatum is also the primary brain region affected in Parkinson’s disease by the loss of dopamine-producing cells.

“People for a long time suspected there has to be this push-pull system,” said co-author Tianyi Mao, Ph.D., a scientist at the Vollum who happens to be married to Zhong.

Read the Full Article
Mao Lab
Zhong Lab

Discovery gives insight into brain function, breakdowns

Dennis WEINGARTEN and Skyler Jackman
Dennis Weingarten, Ph.D., (left) post–doctoral scientist & Skyler Jackman, Ph.D., assistant scientist in the OHSU Vollum Institute, are the co-authors of a neurotransmission discovery that is published in the journal Nature. (OHSU/Christine Torres Hicks)

Scientists at Oregon Health & Science University have identified a long-sought gene-encoded protein that enables the brain to communicate a broad range of signals across gaps between neurons, known as synapses.

The discovery published today in the journal Nature.

Known as synaptotagmin-3, or SYT3, the protein helps to replenish the supply of chemical neurotransmitters that carry signals between neurons.

Read the full OHSU News article here
Jackman Lab

Gouaux Lab discovers mechanism of hearing

In a discovery published today in the journal Nature, OHSU scientists used advanced imaging to reveal the molecular machinery that allows the inner ear to convert vibrations into the sensation of sound.
In a discovery published today in the journal Nature, OHSU scientists used advanced imaging to reveal the molecular machinery that allows the inner ear to convert vibrations into the sensation of sound.

Scientists at Oregon Health & Science University have revealed, for the first time and in near-atomic detail, the structure of the key part of the inner ear responsible for hearing.

“This is the last sensory system in which that fundamental molecular machinery has remained unknown,” said senior author Eric Gouaux, Ph.D., senior scientist with the OHSU Vollum Institute and a Howard Hughes Medical Institute investigator. “The molecular machinery that carries out this absolutely amazing process has been unresolved for decades.”

Until now.

Read the Full Article Here
Gouaux Lab

Dr. Alejandra Fernandez Wins a Collins Medical Trust (CMT) award

Dr Alejandra Fernandez
Dr. Alejandra Fernandez

Congratulations to Dr. Alejandra Fernandez on her Collins Medical Trust (CMT) award. OHSU submitted 13 proposals and Alejandra’s was one of four selected.

Dr. Fernandez studies how sensory neurons in the peripheral nervous system – those then convey information about pain, itch, temperature, body position, and touch – develop in the context of autism spectrum disorders (ASD). Using mouse models, Alejandra is defining how mutations in genes associated with ASD modify the development and function of sensory neurons.

This grant will support Alejandra’s work for the next year.

Recognition for our early career awardees

Graduate students and postdoctoral fellows are usually supported by research grants to individual faculty or by institutional training grants from the NIH. However, a sought-after perk for trainees is to obtain an individual fellowship from federal sources or foundations. Such awards are an honor and also provide important financial support for the trainee and their lab. Graduate students and postdoctoral fellows in the Vollum Institute have been remarkably successful in obtaining these awards over the past few years. This is a credit to the quality of the trainees and the support the receive from their mentors. Congratulations to all.

Congratulations to all of our graduate researchers in the Vollum/OHSU Neuroscience Graduate Program who received ARCS Foundation Scholar Awards from the ARCS Oregon Chapter!

First Year: Milana Krush and Jed Syrenne
Second Year: Teva Bracha and Kim Engeln
Third Year: Sweta Adhikary, Amelia Culp, Makayla Freitas and Sierra Smith

Learn more about these scholars and the ARCS Foundation Oregon

Cody Call, Ph.D., Monk Lab
NINDS F32 Fellowship: "Regulation of node of Ranvier formation and maintenance by astrocytes"

Sarah Clark, Ph.D., Gouaux Lab
NIDCD F32 Fellowship: "Elucidating the architecture and composition of the hair cell mechanotransduction complex"

Alejandra Fernandez, Ph.D., Wright Lab
NINDS K01 Postdoctoral Career Development Award: "The role of Pten on primary sensory neuron development"

Taylor Jay, Ph.D., Freeman Lab
NINDS F32 Fellowship: "Glial regulation of neuronal physiology in response to local injury"

Yunsik Kang, Ph.D., Freeman Lab
Damon Runyon Cancer Research Fellowship: "Molecular mechanisms regulating phagaocytosis of neurons"

Jiaxing Li, Ph.D., Monk Lab
Warren Alpert Foundation Distinguished Scholars Fellowship: "Investigating mechanisms of neuron-oligodendrocyte precursor cell interactions"

Ernesto Manzo, Ph.D., Freeman Lab
NINDS F32 Fellowship: "Defining genetic pathways that drive axon loss"

John Sinnamon, Ph.D., Mandel Lab
Rett Syndrome Research Trust Award: "Using site-directed RNA editing to repair Rett Syndrome mutations in vivo"

Amelia Culp, Mao Lab
National Science Foundation, Graduate Research Fellowship

Makayla Freitas, Gouaux Lab
NINDS F31 Predoctoral Fellowship: "The molecular architecture and mechanism of the Proton Activated Chloride (PAC)"

Alexandra Houser, Baconguis Lab
National Science Foundation, Graduate Research Fellowship

Jennifer Jahncke, Wright Lab
NINDS F31 Predoctoral Fellowship: "Dystroglycan regulates cerebellar synapse function"

Katy Lehmann, Freeman Lab
National Science Foundation, Graduate Research Fellowship

Janelle Tobias, Frank Lab
National Science Foundation, Graduate Research Fellowship

Congratulations to the Neuroscience Graduate Program researchers — Ali Pincus, Prashant Rao and Petra Richer — who received 2020 N.L. Tartar Trust Fellowships. The $2,000 grants are awarded annually by the OHSU School of Medicine as a means to support research endeavors and career development. Keep up the great work!