In the News

Gene-Editing Technique in Human Embryos Draws Skepticism. The Wall Street Journal
Critics challenge a study saying a disease-causing gene mutation was repaired in human embryos

Profiles in precision medicine 
Advances in DNA testing and gene editing have given people choices that would have been impossible a few decades ago. Here, in their own words (including Dr. Paula Amato), are the stories of four people confronted with these dilemmas. 

Scientists take a harder look at genetic engineering of human embryos. Wired
Genetic modification of human embryos is controversial for obvious reasons—and less obvious ones, like whether it really works.

Study verifies gene repair breakthrough. OHSU News.
Research published in Nature confirms discovery of DNA repair mechanism

CBS's 60 Minutes included Shoukhrat Mitalipov and his groundbreaking work in their segment about CRISPR highlighting our efforts to use CRISPR to prevent disease by correcting genes in human embryos.

CBS's 60 Minutes Overtime included a segment with our physician collaborator, Dr. Paula Amato, whom discusses the ethical reasons of pursuing technologies that may be used to prevent disease in future generations.

Science News editors have identified "CRISPR gene editing moves into humans, spurs debate" as their Number 2 story of 2017. OHSU scientists Shoukhrat Mitalipov and Paula Amato's CRISPR research was one of @ScienceNews' top stories of 2017! #SNTop10 

Mitalipov successfully repairs genes in human embryos

A ground breaking discovery by Shoukhrat Mitalipov, Ph.D., was reported in Nature —the successful removal of a lethal genetic defect in human embryos. The breakthrough is the initial confirmation that a dangerous genetic defect can in theory be erased.

Scientific success in embryo editing re-opens reg debate. BioWorld

Study in Nature demonstrates method for repairing genes in human embryos that prevents inherited diseases. OHSU News

In Breakthrough, Scientists Edit a Dangerous Mutation From Genes in Human Embryos. NY Times

First human embryo editing experiment in U.S.'corrects' gene for heart condition. The Washington Post.

Scientists Precisely Edit DNA In Human Embryos To Fix A Disease Gene. NPR

Human embryos edited to stop disease. BBC

A Gene Editing Breakthrough. On Point with Tom Ashbrook. 

First U.S.-based group to edit human embryos brings practice closer to clinic. Science

In breakthrough, OHSU corrects defective gene in embryo. Oregonlive.

First Safe Repair of Gene in Human Embryos. Associated Press. 

New research provides key insight about mitochondrial replacement therapy

A new discovery may unlock the answer to a vexing scientific question: How to conduct mitochondrial replacement therapy, a new gene-therapy technique, in such a way that safely prevents the transmission of harmful mitochondrial gene mutations from mothers to their children.

For women with mitochondrial diseases, a step closer to preventing transmission. STAT

Human embryo experiment shows progress toward 'three-parent' babies.  The Washington Post

New Technique could increase success of infertility treatment

Families struggling with infertility or a genetic predisposition for debilitating mitochondrial diseases may someday benefit from a new breakthrough led by scientists at OHSU and the Salk Institute for Biological Studies.

Egg 'nobbles' can be used to create embryos, say scientists in fertility breakthrough

Fertility success may get boost from new research

Human Cloning at Last: Science

Researchers announced they had derived stem cells from cloned human embryos, a long-awaited research coup that Science's editors chose as a runner-up for Breakthrough of the Year. Read the article on Science

The Top Ten Medical Breakthroughs: Time

The Top Ten Science Stories of 2013: Discover

This Year's Biggest Discoveries in Science: National Geographic

TIME Health Care 50

Robbie McClaran—Redux for TIME

Designing Disease-Free Embryos

The biologist from Oregon Health &Science University shocked people in 2017 when he repaired a genetic mutation causing heart disease in dozens of human embryos. (The embryos were destroyed as per ethical requirements of the experiment.) He used a controversial gene-editing technique called CRISPR that has yet to be proven safe and effective for treating human disease, and critics questioned his results. But this year, Mitalipov defended his findings after re-analyzing the DNA from the embryonic cells, and other groups have reported similar results using CRISPR to repair the mutation in mouse embryos. Mitalipov says he also tested the technique with inherited mutations that cause other diseases, with similar repair success. He sees his studies as the first step toward IVF gene therapy, in which researchers can repair inherited genetic diseases in IVF embryos before they are implanted in the womb. —Alice Park