The OHSU School of Dentistry is a hub for research into dental disease, clinical practices, oral biology, and basic biomedical research. With over 20 principal investigators and a large technical team, we conduct a wide range of research projects, from the causes of diseases to evidence-based dental treatments. Our research is funded by Federal grants (NIH, NSF, NASA) and a wide range of corporate sponsors. Our research faculty conducts studies on a wide range of topics related to dental healthcare. To learn more about our innovative research and possible research opportunities with us, contact the principal investigators or the Office of Research Affairs at the School of Dentistry.
The OHSU School of Dentistry's labs conduct groundbreaking research into dental healthcare. Our scientists specialize in developing biomaterials for replacing oral tissues, cell and developmental biology, oral microbiology, and immunology. As one of the leading dental healthcare research institutions, we contribute to improving the lives of patients with innovative treatments. Our state-of-the-art facilities provide an excellent platform for interdisciplinary collaboration, which allows us to partner with the School of Medicine and the Knight Cancer Institute on exceptional projects.
Welcome from the Associate Dean of Research
“We welcome you to explore the OHSU School of Dentistry's research facilities. Our lab is an interdisciplinary team of clinical investigators, public health experts, and laboratory scientists committed to advancing dental healthcare. Our leading-edge lab facilities allow us to conduct multidisciplinary research and help young investigators and trainees flourish in their research careers. Contact us to learn more about our mission in fostering innovation and exploration in dental healthcare..”
Associate Dean of Research, Hui Wu, Ph.D.
Office of Research
Senior Grants and Contracts Coordinator
Finance and Accounting Analyst 2
Research Program Coordinator
Labs by research focus
Biomaterials, tissue engineering and regeneration
Scientists at OHSU School of Dentistry are studying the synthesis and development of new biomaterials for the replacement of lost or damaged oral tissues. This research includes the development of new materials for tooth repair, such as resin-based dental adhesives and restoratives having enhanced durability, antimicrobial behavior and remineralizing potential. The team is actively involved in research involving the interaction between dental biomaterials and oral biofilms to produce material solutions with enhanced clinical longevity and performance. Another strategy involves the use of 3D bioprinting of scaffolds containing cells and bioactive molecules for tissue regeneration.
Neuroscience, cell and development biology
In addition to research focused directly on issues of oral health, there is a significant research focus on basic biomedical research questions, in particular in neuroscience, cell and developmental biology. OHSU School of Dentistry scientists have research programs that explore the mechanisms underlying pain, neurodegeneration, cell fate specification, morphogenesis and cell signaling. These areas of research impact all aspects of human health and disease, including, but not limited to, oral health and biology.
Oral microbiology and immunology
Research in the Oral Microbiology and Immunology domain at OHSU School of Dentistry is focused upon the genetics, ecology, and host responses to the oral microbiome in both health and disease. This includes fundamental molecular microbiology studies of both commensal and pathogenic oral microbiota as well as the ecological interactions occurring among the microbiome and with the host. Studies of the host response to infection include a focus upon innate immunity and its role in promoting oral diseases. Another research focus within this cluster is concerned with the interface of dental biomaterials and oral biofilms. The goal is to better understand the reciprocal interactions that affect both the integrity of the dental materials and the behavior of the organisms colonizing the surfaces of the materials.
Public health dentistry, education, informatics and clinical research
As the Chair of Community Dentistry, Dr. Eli Schwarz states "Oregon is our laboratory." OHSU School of Dentistry provides outreach and cutting edge technology at on-campus OHSU dental clinics in Portland, and across the far reaches of the state, developing strategic collaborations with rural partners and incorporating teledentistry to ensure that quality oral health care is available for all Oregonians. Community and clinical research endeavors advance knowledge of topics that affect oral health, including nutrition and opioid use. Clinical and community researchers in SOD work in tandem with basic scientists to develop clinical-translational research methods that will have long-lasting effects in the field of dentistry.