Center for Policy and Research in Emergency Medicine (CPR-EM)

The OHSU Center for Policy and Research in Emergency Medicine's breakthrough research leads to new standards of care and a better understanding of important issues involving emergency medicine, disaster preparedness, and toxicology.

The CPR-EM was established to promote several long-term goals:

  1. Partner with policy-makers locally, state-wide and nationally, in identifying areas in which high-quality research can contribute to important health policy issues.
  2. Increase the contribution of Emergency Medicine faculty members to important health policy issues facing our community, our state and our nation.
  3. Enhance the research activities of the Department of Emergency Medicine, seeking external funding to facilitate this goal.

In the Media

Oregon Emergency Care Research Multidisciplinary Training Program Newgard, C. & Morris, C. | National Institutes of Health | 8/15/16 - 6/30/21  K12 Training Program.

The Value of Emergency Care For Injured Older Adults
Newgard, C. | National Institutes of Health | 5/1/15 - 4/30/19

The Value of Pediatric Readiness in the Emergency Care of Injured Children
Newgard, C. | National Institute of Child Health & Human Development | 9/30/17 - 6/30/22

Additional emergency medicine research statistics can be found on the OHSU Research Expertise website. 

"There is a lot going on in our Emergency Department! Thank you for your continued support to make these trials successful. Keep moving that needle of science forward as we provide high-quality healthcare."

- Bory Kea, MD, MCR, FACEP - Director of Clinical Trial, Department of Emergency Medicine

Heart Failure Pro BNP Study

Evaluating a new pro-BNP assay in patients with heart failure (for diagnosis and severity assessment)

PI: Dr. Kea; Coordinator: Joy Kim

Inclusion criteria: >21 yo, with SOB and/or edema; enrollment within 11hrs of presentation

Exclusion: Trauma, on dialysis, prisoner, homelessness, and prior enrollment

Enrollment-to-date: 26 

Site Goal: 100 (enrollment period through end of 2019)


A novel device for distal perfusion: currently enrolling in kids and adults

PI: Dr. Sheridan; Coordinator: Nancy Le

Enrollment-to-date: 33

Goal: 600 until October

**This study will transition in October to a pediatric dehydration device study if able to enroll site goal**


Wearable technology for physiologic monitoring of adolescent suicidality: enrolls adolescents presenting with suicidality with goal of developing objective/physiologic markers that correlate with escalating suicidality

PI: Dr. Sheridan; Coordinator: Nancy Le

Enrollment-to-date: 67

Goal: 200 across the pediatric ER and inpatient adolescent psychiatric unit at Unity

BOOST-3 Brain Oxygen Optimization in Severe TBI Phase-3 Trial

PI: Dr. Daya, ED Coordinator: Jenny Cook; Trauma Research Group Coordiators: Samantha Underwood & Keeley McConnell

Registered with NCT03754114

Status: Pre-study preparations

BOOST 3 is a trial being run through the nationwide SIREN Network.OHSU is a “award hub”, and 4 of our OHSU network sites will also be participating in this trial (OSU, Duke, University of Utah, and University of Rochester Medical Center).  A total of 45 sites will be enrolling patients throughout the duration of this trial.

BOOST 3 will operate under EFIC (Exception from Informed Consent) rules, and is currently conducting community consultation activities in the Portland Metro Area.

Enrollment is expected to begin in October 2019 at OHSU.

Learn more here


Giving vitamin C, thiamine, and steroids in patients with septic shock or respiratory failure from sepsis (ventilator, BiPAP, HFNC dependent)

Site Enrollment: 23

Site Goal: 140 until September 2021 (1 per week)

Status: Closed to enrollment (as of 8/7/19 - check back for updates)

Total Enrollment Goal: 500 until September 2021 


Using liberal fluid strategy vs early vasopressor strategy in patients with Septic Shock (sepsis + hypotension)

Site Enrollment: 71

Site Goal: 146 April 2021 (1 per week)

Total Enrollment Goal: 2200 until April 2021

Recent Publications

Recognising bias in studies of diagnostic tests part 2: interpreting and verifying the index test. Kea B, Hall MK, Wang R. Emerg Med J. 2019 Aug;36(8):501-505. doi: 10.1136/emermed-2019-208447. Epub 2019 Jun 20. PMID: 31221671

Acute cannabis toxicity. Noble MJ, Hedberg K, Hendrickson RG.  Clin Toxicol (Phila). 2019 Aug;57(8):735-742. doi: 10.1080/15563650.2018.1548708. Epub 2019 Jan 24. PMID: 30676820

What is the most appropriate dose of N-acetylcysteine after massive acetaminophen overdose? Hendrickson RG. Clin Toxicol (Phila). 2019 Aug;57(8):686-691. doi: 10.1080/15563650.2019.1579914. Epub 2019 Feb 19. PMID: 30777470

Clinical Benefit of Hospitalization for Older Adults With Unexplained Syncope: A Propensity-Matched Analysis. Probst MA, Su E, Weiss RE, Yagapen AN, Malveau SE, Adler DH, Bastani A, Baugh CW, Caterino JM, Clark CL, Diercks DB, Hollander JE, Nicks BA, Nishijima DK, Shah MN, Stiffler KA, Storrow AB, Wilber ST, Sun BC. Ann Emerg Med. 2019 Aug;74(2):260-269. doi: 10.1016/j.annemergmed.2019.03.031. Epub 2019 May 9. PMID: 31080027

Introducing The Penumbra. Choo EK. Lancet. 2019 Aug 10;394(10197):453-454. doi: 10.1016/S0140-6736(19)31798-2. Epub 2019 Aug 8. No abstract  available. PMID: 31402015

The "nice work" of transforming the health workforce. Choo EK.  Lancet. 2019 Aug 10;394(10197):461. doi: 10.1016/S0140-6736(19)31681-2. Epub 2019 Aug 8. No abstract available. PMID: 31402017

Addressing Social Determinants of Health through Medicaid: Lessons from Oregon. Kushner J, McConnell KJ. J Health Polit Policy Law. 2019 Aug 8. pii: 7785823. doi: 10.1215/03616878-7785823. [Epub ahead of print] PMID: 31408877

Reply to "In response to "Coagulopathy and bleeding associated with salicylate toxicity" ". Hatten BW, Hendrickson RG. Clin Toxicol (Phila). 2019 Aug 15:1. doi: 10.1080/15563650.2019.1650939. [Epub ahead of print] No abstract available. PMID: 31416368

Methemoglobinemia associated with massive acetaminophen ingestion: a case series. Rianprakaisang T, Blumenberg A, Hendrickson RG. Clin Toxicol (Phila). 2019 Aug 26:1-3. doi: 10.1080/15563650.2019.1657883. [Epub ahead of print] PMID: 31446806

Massive fatal overdose of abrin with progressive encephalopathy.  Horowitz BZ, Castelli R, Hughes A, Hendrickson RG, Johnson RC, Thomas JD. Clin Toxicol (Phila). 2019 Aug 28:1-4. doi: 10.1080/15563650.2019.1655150. [Epub ahead of print] PMID: 31456429

Dana Zive

It is with a heavy heart that we announce the passing of our esteemed colleague,  Dana Zive, Sunday, September 30, 2018.

 Dana was the Director of the Oregon POLST Registry, Associate Director of the OHSU Center for Ethics in Health Care, and a Research Assistant Professor in the OHSU Department of Emergency Medicine and CPR-EM.  She earned her B.S. in Environmental Chemistry and Toxicology at the University of Nevada, Reno, and her M.P.H. in Public Health Education and Biostats/Epidemiology from San Jose State University.  Dana joined OHSU in 2004, and her areas of focus included end-of-life care and emergency care research. 

 Dana was integrally involved in many DEM research efforts, including the Resuscitation Outcomes Consortium (many out-of-hospital interventional trials in cardiac arrest and trauma) and the Physician Orders for Life-Sustaining Treatment Program (POLST).  She was key in developing and implementing the Oregon electronic POLST registry, including legislated state funding. Dana has been a fundamental member of CPREM throughout our years of building infrastructure and growth.  She had a true research mind and a passion for data. She was our colleague and friend and will be dearly missed. 

Dana is survived by her husband and daughter (Lola, 8).   If you have a story about Dana you would like to share with her family, please send your thoughts to