Center for Policy and Research in Emergency Medicine (CPR-EM)

The OHSU Center for Policy and Research in Emergency Medicine's breakthrough research leads to new standards of care and a better understanding of important issues involving emergency medicine, disaster preparedness, and toxicology.

The CPR-EM was established to promote several long-term goals:

  1. Partner with policy-makers locally, state-wide and nationally, in identifying areas in which high-quality research can contribute to important health policy issues.
  2. Increase the contribution of Emergency Medicine faculty members to important health policy issues facing our community, our state and our nation.
  3. Enhance the research activities of the Department of Emergency Medicine, seeking external funding to facilitate this goal.

In the Media

Craig Newgard

“Oregon Emergency Care Research Multidisciplinary Training Program”

Sponsor: National Heart, Lung, and Blood Institute (NHLBI), National Institute of Mental Health (NIMH), National Institute of Nursing Research (NINR) - 1K12HL133115

Award Dates: 08/15/16-06/30/21

Role: Principal Investigator

“The Value of Pediatric Readiness in the Emergency Care of Injured Children”

Sponsor: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHHD) - 1R24HD085927

Award Dates: 09/30/17-06/30/22

Role: Principal Investigator

“A Multi-State Evaluation of Emergency Department Pediatric Readiness: Guideline Uptake and Association with Quality, Outcomes, and Cost”

Sponsor: Health Resources and Services Administration (HRSA) Maternal and Child Health Bureau - 1H34MC332430100

Award Dates: 09/01/19-08/31/23

Role: Principal Investigator

“Comparative Effectiveness of Trauma Center Care for Older Americans”

Sponsor: Brigham and Women's Hospital Inc (BWH) via National Institute on Aging (NIA) - 1R56AG048452-01A1

Award Dates: 09/30/17-08/31/19

Role: Site Principal Investigator / Co-Investigator

Additional emergency medicine research statistics can be found on the OHSU Research Expertise website. 
 

Esther Choo

“Implementation, Outcomes, and Cost of a Novel Medicaid Policy to Reduce
Opioids for Back Pain”

Sponsor: National Institute on Drug Abuse (NIDA) - 1R01DA044284

Award Dates: 08/15/18-05/31/23

Role: Principal Investigator

“Risk of Motor Vehicle Crashes from Cannabis Use in Emergency Department
Patients”

Sponsor: Insurance Institute for Highway Safety (IIHS)

Award Dates: 11/01/16-04/30/20

Role: Principal Investigator

“Virtual Coaching in Making Informed Choices on Elder Abuse/Neglect Self-Disclosure (VOICES)”

Sponsor: Yale University via NIA - 1R01AG060084

Award Dates: 09/01/18-08/31/22

Role: Site Principal Investigator / Co-Investigator

Matthew Hansen

“Improving the Safety and Efficacy of Out-of-Hospital Pediatric Airway Management”

Sponsor: National Heart, Lung, and Blood Institute - 1K23HL131440

Award Dates: 09/26/16-08/31/20

Role: Principal Investigator

“Charlotte, Houston, and Milwaukee Prehospital (CHaMP) Research Node”

Sponsor: Health Resources and Services Administration (HRSA) Bureau of Health Professions - 5H34MC26201

Award Dates: 09/01/17-08/31/20

Role: Site Principal Investigator / Co-Investigator

“The Charlotte, Houston, and Milwaukee Prehospital (CHaMP) Research Node”

Sponsor: Health Resources and Services Administration (HRSA) Maternal and Child Health Bureau - U03MC33154

Award Dates: 09/01/19-08/31/23

Role: Site Principal Investigator / Co-Investigator

Bory Kea

“Optimal Anticoagulation Strategies for Acute Atrial Fibrillation”

Sponsor: National Heart, Lung, and Blood Institute - 1K08HL140105

Award Dates: 12/15/17-11/30/20

Role: Principal Investigator

“Specimen Collection in the Emergency Department for the Assessment of Clinical Performance of the Siemens PBNP Assay”

Sponsor: Siemens Healthcare Diagnostics

Award Dates: 06/12/19-06/30/22

Role: Principal Investigator

“BUILD EXITO Y6”

Sponsor: EXITO Institutional Core

Award Dates: 11/01/19-06/30/20

Role: Principal Investigator

“VITROS® Immunodiagnostic Products hs Troponin I US Sample Collection Protocol”

Sponsor: Ortho-Clinical Diagnostics Inc

Award Dates: 06/18/18-06/30/21

Role: Principal Investigator

Brandon Maughan

“Sex-Based Differences in Risk Stratification and Diagnostic Imaging for Diagnosis of Pulmonary Embolism”

Sponsor: Oregon Emergency Care Research Multidisciplinary Training Program - National Heart, Lung, and Blood Institute - 5K12HL133115

Award Dates: 07/01/18-08/30/21

Role: Scholar

David Sheridan

“West Coast Consortium for Technology and Innovation in Pediatrics”

Sponsor: Children's Hospital Los Angeles (CHLA) via FDA - 1P50FD006425

Award Dates: 09/01/18-08/31/23

Role: Site Principal Investigator / Co-Investigator

“Solace: A Wearable Continuous Early Suicide Warning System for Adolescents”

Sponsor: Oregon Emergency Care Research Multidisciplinary Training Program

National Institute of Mental Health / National Heart, Lung, and Blood Institute - 5K12HL133115

Award Dates: 07/01/18-06/30/21

Role: Scholar

“SRA-19-145 ProMedix, Inc.”

Sponsor: ProMedix, Inc.

Award Dates: 08/01/19-07/31/20

Role: Principal Investigator

“Physiologic Parameters Related to Suicidality in Adolescent Mental Health”

Sponsor: Welch Allyn

Award Dates: 01/01/19-01/31/22

Role: Principal Investigator

Andrew Moore

“A Randomized Controlled Trial of Usual Care Plus Mobile Cardiac Telemetry Versus Usual Care Alone for Unexplained Syncope in Older Adults Evaluated in the Emergency Department”

Sponsor: Medical Research Foundation (MRF) Early Clinical Investigator (ECI) Award

Award Dates: 04/01/20-03/31/21

Role: Principal Investigator

Mohamud Daya

Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) -
Network Clinical Center (Award Hub)”

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) - 1U24NS100657

Award Dates: 07/15/17-05/31/22

Role: Principal Investigator

“Characterizing Prehospital Delay and Outcomes in Patients Treated for Potential Acute Coronary Syndrome in the Emergency Department”

Sponsor: University of California, Los Angeles (UCLA) via National Heart, Lung, and Blood Institute - 1R21HL140277

Award Dates: 08/01/18-07/31/20

Role: Site Principal Investigator / Co-Investigator

"There is a lot going on in our Emergency Department! Thank you for your continued support to make these trials successful. Keep moving that needle of science forward as we provide high-quality healthcare."

- Bory Kea, MD, MCR, FACEP - Director of Clinical Trial, Department of Emergency Medicine

Heart Failure Pro BNP Study

Evaluating a new pro-BNP assay in patients with heart failure (for diagnosis and severity assessment)

PI: Dr. Kea; Coordinator: Joy Kim

Inclusion criteria: >21 yo, with SOB and/or edema; enrollment within 11hrs of presentation

Exclusion: Trauma, on dialysis, prisoner, homelessness, and prior enrollment

Enrollment-to-date: 26 

Site Goal: 100 (enrollment period through end of 2019)

HydraSense

A novel device for distal perfusion: currently enrolling in kids and adults

PI: Dr. Sheridan; Coordinator: Nancy Le

Enrollment-to-date: 33

Goal: 600 until October

**This study will transition in October to a pediatric dehydration device study if able to enroll site goal**

Solace

Wearable technology for physiologic monitoring of adolescent suicidality: enrolls adolescents presenting with suicidality with goal of developing objective/physiologic markers that correlate with escalating suicidality

PI: Dr. Sheridan; Coordinator: Nancy Le

Enrollment-to-date: 67

Goal: 200 across the pediatric ER and inpatient adolescent psychiatric unit at Unity

BOOST-3 Brain Oxygen Optimization in Severe TBI Phase-3 Trial

PI: Dr. Daya, ED Coordinator: Jenny Cook; Trauma Research Group Coordiators: Samantha Underwood & Keeley McConnell

Registered with ClinicalTrials.gov: NCT03754114

Status: Pre-study preparations

BOOST 3 is a trial being run through the nationwide SIREN Network.OHSU is a “award hub”, and 4 of our OHSU network sites will also be participating in this trial (OSU, Duke, University of Utah, and University of Rochester Medical Center).  A total of 45 sites will be enrolling patients throughout the duration of this trial.

BOOST 3 will operate under EFIC (Exception from Informed Consent) rules, and is currently conducting community consultation activities in the Portland Metro Area.

Enrollment is expected to begin in January 2020 at OHSU.

Learn more here

VICTAS

Giving vitamin C, thiamine, and steroids in patients with septic shock or respiratory failure from sepsis (ventilator, BiPAP, HFNC dependent)

Site Enrollment: 23

Site Goal: 140 until September 2021 (1 per week)

Status: Closed to enrollment (as of 8/7/19 - check back for updates)

Total Enrollment Goal: 500 until September 2021 

CLOVERS

Using liberal fluid strategy vs early vasopressor strategy in patients with Septic Shock (sepsis + hypotension)

Site Enrollment: 71

Site Goal: 146 April 2021 (1 per week)

Total Enrollment Goal: 2200 until April 2021

Recent Publications

Association of the Mandatory Medicare Bundled Payment With Joint Replacement Outcomes in Hospitals With Disadvantaged Patients. Kim H, Meath THA, Dobbertin K, Quiñones AR, Ibrahim SA, McConnell KJ. JAMA Netw Open. 2019 Nov 1;2(11):e1914696. doi: 10.1001/jamanetworkopen.2019.14696. PMID: 31693127

Serotonin Toxicity: Associated Agents and Clinical Characteristics. Moss MJ, Hendrickson RG; Toxicology Investigators Consortium (ToxIC). J Clin Psychopharmacol. 2019 Nov/Dec;39(6):628-633. doi: 10.1097/JCP.0000000000001121. PMID: 31688388

Acetaminophen-associated methemoglobinemia. Rianprakaisang T, Blumenberg A, Hendrickson RG. Clin Toxicol (Phila). 2019 Nov 4:1. doi: 10.1080/15563650.2019.1682153. [Epub ahead of print] No abstract available. PMID: 31682157

Disparity in Receipt and Utilization of Telecommunicator CPR Instruction. Amen A, Karabon P, Bartram C, Irwin K, Dunne R, Wolff M, Daya MR, Vellano K, McNally B, Jacobsen RC, Swor R, Cares Surveillance Group. Prehosp Emerg Care. 2019 Nov 13:1-6. doi: 10.1080/10903127.2019.1680781. [Epub ahead of print] PMID: 31613657

National Study of Triage and Access to Trauma Centers for Older Adults. Uribe-Leitz T, Jarman MP, Sturgeon DJ, Harlow AF, Lipsitz SR, Cooper Z, Salim A, Newgard CD, Haider AH. Ann Emerg Med. 2019 Nov 13. pii: S0196-0644(19)30528-1. doi: 10.1016/j.annemergmed.2019.06.018. [Epub ahead of print] PMID: 31732372

Evaluation and Management of Intermediate and High-Risk Pulmonary Embolism. Al-Hakim R, Li N, Nonas S, Zakhary B, Maughan B, Schenning R, Farsad K, Kaufman JA. AJR Am J Roentgenol. 2019 Nov 19:1-8. doi: 10.2214/AJR.19.21861. [Epub ahead of print] PMID: 31743047

The Psychoactive Surveillance Consortium and Analysis Network (PSCAN): the first year. Monte AA, Hopkinson A, Saben J, Shelton SK, Thornton S, Schneir A, Pomerleau A, Hendrickson RG, Arens AM, Cole JB, Chenoweth J, Martin S, Adams A, Banister SD, Gerona RR. Addiction. 2019 Nov 25. doi: 10.1111/add.14808. [Epub ahead of print] PMID: 31769125

9th Edition of the Tintinalli EM textbook with chapters by: Bailey, Bengtzen, Ferroggiaro, Hansen, Heilman, Hendrickson, Horowitz, Jones, Kornegay, Mayersak, Sheridan, Tanksi and Wang.

Dana Zive

It is with a heavy heart that we announce the passing of our esteemed colleague,  Dana Zive, Sunday, September 30, 2018.

 Dana was the Director of the Oregon POLST Registry, Associate Director of the OHSU Center for Ethics in Health Care, and a Research Assistant Professor in the OHSU Department of Emergency Medicine and CPR-EM.  She earned her B.S. in Environmental Chemistry and Toxicology at the University of Nevada, Reno, and her M.P.H. in Public Health Education and Biostats/Epidemiology from San Jose State University.  Dana joined OHSU in 2004, and her areas of focus included end-of-life care and emergency care research. 

 Dana was integrally involved in many DEM research efforts, including the Resuscitation Outcomes Consortium (many out-of-hospital interventional trials in cardiac arrest and trauma) and the Physician Orders for Life-Sustaining Treatment Program (POLST).  She was key in developing and implementing the Oregon electronic POLST registry, including legislated state funding. Dana has been a fundamental member of CPREM throughout our years of building infrastructure and growth.  She had a true research mind and a passion for data. She was our colleague and friend and will be dearly missed. 

Dana is survived by her husband and daughter (Lola, 8).   If you have a story about Dana you would like to share with her family, please send your thoughts to cookjen@ohsu.edu