Center for Policy and Research in Emergency Medicine (CPR-EM)
CRISP Volunteer Research Internship Program Operations Suspended
3/13/2020 - Due to the COVID-19 pandemic, all CRISP operations and activities are on HOLD until April 30, 2020. We will update current CRISP team members and the CRISP website with additional information as it becomes available.
The OHSU Center for Policy and Research in Emergency Medicine's breakthrough research leads to new standards of care and a better understanding of important issues involving emergency medicine, disaster preparedness, and toxicology.
The CPR-EM was established to promote several long-term goals:
- Partner with policy-makers locally, state-wide and nationally, in identifying areas in which high-quality research can contribute to important health policy issues.
- Increase the contribution of Emergency Medicine faculty members to important health policy issues facing our community, our state and our nation.
- Enhance the research activities of the Department of Emergency Medicine, seeking external funding to facilitate this goal.
In the Media
Craig Newgard
“Oregon Emergency Care Research Multidisciplinary Training Program”
Sponsor: National Heart, Lung, and Blood Institute (NHLBI), National Institute of Mental Health (NIMH), National Institute of Nursing Research (NINR) - 1K12HL133115
Award Dates: 08/15/16-06/30/21
Role: Principal Investigator
“The Value of Pediatric Readiness in the Emergency Care of Injured Children”
Sponsor: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHHD) - 1R24HD085927
Award Dates: 09/30/17-06/30/22
Role: Principal Investigator
“A Multi-State Evaluation of Emergency Department Pediatric Readiness: Guideline Uptake and Association with Quality, Outcomes, and Cost”
Sponsor: Health Resources and Services Administration (HRSA) Maternal and Child Health Bureau - 1H34MC332430100
Award Dates: 09/01/19-08/31/23
Role: Principal Investigator
“Comparative Effectiveness of Trauma Center Care for Older Americans”
Sponsor: Brigham and Women's Hospital Inc (BWH) via National Institute on Aging (NIA) - 1R56AG048452-01A1
Award Dates: 09/30/17-08/31/19
Role: Site Principal Investigator / Co-Investigator
Additional emergency medicine research statistics can be found on the OHSU Research Expertise website.
Esther Choo
“Implementation, Outcomes, and Cost of a Novel Medicaid Policy to Reduce
Opioids for Back Pain”
Sponsor: National Institute on Drug Abuse (NIDA) - 1R01DA044284
Award Dates: 08/15/18-05/31/23
Role: Principal Investigator
“Risk of Motor Vehicle Crashes from Cannabis Use in Emergency Department
Patients”
Sponsor: Insurance Institute for Highway Safety (IIHS)
Award Dates: 11/01/16-04/30/20
Role: Principal Investigator
“Virtual Coaching in Making Informed Choices on Elder Abuse/Neglect Self-Disclosure (VOICES)”
Sponsor: Yale University via NIA - 1R01AG060084
Award Dates: 09/01/18-08/31/22
Role: Site Principal Investigator / Co-Investigator
Matthew Hansen
“Improving the Safety and Efficacy of Out-of-Hospital Pediatric Airway Management”
Sponsor: National Heart, Lung, and Blood Institute - 1K23HL131440
Award Dates: 09/26/16-08/31/20
Role: Principal Investigator
“Charlotte, Houston, and Milwaukee Prehospital (CHaMP) Research Node”
Sponsor: Health Resources and Services Administration (HRSA) Bureau of Health Professions - 5H34MC26201
Award Dates: 09/01/17-08/31/20
Role: Site Principal Investigator / Co-Investigator
“The Charlotte, Houston, and Milwaukee Prehospital (CHaMP) Research Node”
Sponsor: Health Resources and Services Administration (HRSA) Maternal and Child Health Bureau - U03MC33154
Award Dates: 09/01/19-08/31/23
Role: Site Principal Investigator / Co-Investigator
Bory Kea
“Optimal Anticoagulation Strategies for Acute Atrial Fibrillation”
Sponsor: National Heart, Lung, and Blood Institute - 1K08HL140105
Award Dates: 12/15/17-11/30/20
Role: Principal Investigator
“Specimen Collection in the Emergency Department for the Assessment of Clinical Performance of the Siemens PBNP Assay”
Sponsor: Siemens Healthcare Diagnostics
Award Dates: 06/12/19-06/30/22
Role: Principal Investigator
“BUILD EXITO Y6”
Sponsor: EXITO Institutional Core
Award Dates: 11/01/19-06/30/20
Role: Principal Investigator
“VITROS® Immunodiagnostic Products hs Troponin I US Sample Collection Protocol”
Sponsor: Ortho-Clinical Diagnostics Inc
Award Dates: 06/18/18-06/30/21
Role: Principal Investigator
Brandon Maughan
“Sex-Based Differences in Risk Stratification and Diagnostic Imaging for Diagnosis of Pulmonary Embolism”
Sponsor: Oregon Emergency Care Research Multidisciplinary Training Program - National Heart, Lung, and Blood Institute - 5K12HL133115
Award Dates: 07/01/18-08/30/21
Role: Scholar
David Sheridan
“West Coast Consortium for Technology and Innovation in Pediatrics”
Sponsor: Children's Hospital Los Angeles (CHLA) via FDA - 1P50FD006425
Award Dates: 09/01/18-08/31/23
Role: Site Principal Investigator / Co-Investigator
“Solace: A Wearable Continuous Early Suicide Warning System for Adolescents”
Sponsor: Oregon Emergency Care Research Multidisciplinary Training Program
National Institute of Mental Health / National Heart, Lung, and Blood Institute - 5K12HL133115
Award Dates: 07/01/18-06/30/21
Role: Scholar
“SRA-19-145 ProMedix, Inc.”
Sponsor: ProMedix, Inc.
Award Dates: 08/01/19-07/31/20
Role: Principal Investigator
“Physiologic Parameters Related to Suicidality in Adolescent Mental Health”
Sponsor: Welch Allyn
Award Dates: 01/01/19-01/31/22
Role: Principal Investigator
Andrew Moore
“A Randomized Controlled Trial of Usual Care Plus Mobile Cardiac Telemetry Versus Usual Care Alone for Unexplained Syncope in Older Adults Evaluated in the Emergency Department”
Sponsor: Medical Research Foundation (MRF) Early Clinical Investigator (ECI) Award
Award Dates: 04/01/20-03/31/21
Role: Principal Investigator
Mohamud Daya
“Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) -
Network Clinical Center (Award Hub)”
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) - 1U24NS100657
Award Dates: 07/15/17-05/31/22
Role: Principal Investigator
“Characterizing Prehospital Delay and Outcomes in Patients Treated for Potential Acute Coronary Syndrome in the Emergency Department”
Sponsor: University of California, Los Angeles (UCLA) via National Heart, Lung, and Blood Institute - 1R21HL140277
Award Dates: 08/01/18-07/31/20
Role: Site Principal Investigator / Co-Investigator
Due to the COVID-19 Pandemic, some of the ED research projects listed below are currently suspended from enrolling subjects, however our research teams continue to engage in research activities that can be accomplished.
There is a lot going on in our Emergency Department! And with the expansion in hospitals, we welcome Adventist, Tuality, and CMH to the team, and hope the other sites will consider future research opportunities. Thank you for your continued support to make these trials successful. Each, and every one of you, are needed to move the needle of science forward as we provide high-quality healthcare.
Heart Failure Pro BNP Study
Evaluating a new pro-BNP assay in patients with heart failure (for diagnosis and severity assessment)
PI: Dr. Kea; Coordinator: Joy Kim
Inclusion criteria: >21 yo, with SOB and/or edema; enrollment within 11hrs of presentation
Exclusion: Trauma, on dialysis, prisoner, homelessness, and prior enrollment
Enrollment-to-date: 56
Site Goal: 100 (enrollment period through February 2020)
Digital Capillary Refill with HydraSense
Using a novel device (Hydrasense) to compare manual vs digital capillary refill: currently enrolling in patients 6mo-65yo.
PI: Dr. Sheridan; Coordinator: Nancy Le
Enrollment-to-date: 184
Goal: 600 until October
HydraSense for Sepsis
A novel device for distal perfusion: currently enrolling in patients 6mo-65yo with fever, sepsis, and ESI 2-3.
- PI: David Sheridan; Coordinator: Nancy Le
- Enrollment-to-date: 15
Enrollment Goal: 100
Solace
Wearable technology for physiologic monitoring of adolescent suicidality: enrolls adolescents presenting with suicidality with goal of developing objective/physiologic markers that correlate with escalating suicidality
PI: Dr. Sheridan; Coordinator: Nancy Le
Enrollment-to-date: 67
Goal: 200 across the pediatric ER and inpatient adolescent psychiatric unit at Unity
BOOST-3 Brain Oxygen Optimization in Severe TBI Phase-3 Trial
BOOST 3 is a trial being run through the nationwide SIREN Network. OHSU is an “award hub”, and 4 of our OHSU network sites will also be participating in this trial (OSU, Duke, University of Utah, and University of Rochester Medical Center). A total of 45 sites will be enrolling patients throughout the duration of this trial. BOOST 3 will operate under EFIC (Exception from Informed Consent) rules, and is currently conducting public disclosure activities, and final team training.
PI: Dr. Daya, ED Coordinator: Jenny Cook;
Trauma Research Group Coordinators: Samantha Underwood & Keeley McConnell
Registered with ClinicalTrials.gov: NCT03754114
Status: Pre-study preparations
Enrollment is expected to begin in January 2020 at OHSU.
ICECAP- Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (a SIREN Network Study)
OHSU will enroll patients locally at Portland Adventist and OHSU. Additionally, OHSU is anticipating that 5-6 of its network partners will also be conducting ICECAP.
- PI: Daya Coordinator: Nancy Le
- Status: Pre-study Preparation
Launch: Spring 2020
ICU-ED Sepsis Studies
Questions for ICU team?
- Contact our study team Smartweb à Last Name à PRISM (#11912) (8am to 9pm)
Site PI Akram Khan (khana@ohsu.edu) pager à 15351 or text/cell 503-449-4314 (24 hours).
VICTAS
Giving vitamin C, thiamine, and steroids in patients with septic shock or respiratory failure from sepsis (ventilator, BiPAP, HFNC dependent)
PI: Akram Khan; Bory Kea
Site Enrollment: 23
Status: Closed to enrollment (as of 8/7/19 - check back for updates)
Total Enrollment Goal of 500 REACHED across 43 sites
CLOVERS
Using liberal fluid strategy vs early vasopressor strategy in patients with Septic Shock (sepsis + hypotension)
PI: Akram Khan, Co-I: Bory Kea
Site Enrollment: 104
Site Goal: 146 April 2021 (1 per week)
Total Enrollment Goal: 2200 until April 2021
IVY
Multi-center observational study evaluating the efficacy of influenza vaccines among critically ill and hospitalized patients
- PI: Akram Khan
- Site Enrollment: 58
- Site Goal: 100 until March 2020 (5 per week)
Total Enrollment Goal: 700 until March 2020
CLOSED STUDY: ESETT- Established Status Epilepticus Treatment Trial (a NETT Network study)
The ESETT Trial was conducted at OHSU from November 2015-June 2018, and OHSU enrolled 9 subjects locally, and 2 at our satellite site in Utah.
- Findings from this trial were published on Nov. 28, 2019 in the New England Journal of Medicine, https://nett.umich.edu/sites/default/files/docs/nejm-esett_primary.pdf
Research Groups
Career Development
Recent Publications
Race as a dynamic state: triangulation in health care. Blackstock U, Choo EK. Lancet. 2020 Jan 4;395(10217):21. doi: 10.1016/S0140-6736(19)33143-5. Epub 2020 Jan 2. No abstract available. PMID: 31982045
Effectiveness of Emergency Department Treatment of Pediatric Headache and Relation to Rebound Headache. Sheridan DC, Dhatt S, Narayan K, Lin A, Fu R, Meckler GD. Pediatr Emerg Care. 2020 Jan 9. doi: 10.1097/PEC.0000000000002027. [Epub ahead of print] PMID: 31929393
Survival After Intravenous Versus Intraosseous Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Shock-Refractory Cardiac Arrest. Daya MR, Leroux BG, Dorian P, Rea TD, Newgard CD, Morrison LJ, Lupton JR, Menegazzi JJ, Ornato JP, Sopko G, Christenson J, Idris A, Mody P, Vilke GM, Herdeman C, Barbic D, Kudenchuk PJ; Resuscitation Outcomes Consortium Investigators. Circulation. 2020 Jan 21;141(3):188-198. doi: 10.1161/CIRCULATIONAHA.119.042240. Epub 2020 Jan 16. PMID: 31941354
Gender Differences in Authorship of Critical Care Literature. Vranas KC, Ouyang D, Lin AL, Slatore CG, Sullivan DR, Prasad Kerlin M, Liu KD, Baron RM, Calfee CS, Ware LB, Halpern S, Matthay MA, Herridge M, Mehta S, Rogers AJ. Am J Respir Crit Care Med. 2020 Jan 22. doi: 10.1164/rccm.201910-1957OC. [Epub ahead of print] PMID: 31968182
A neighborhood analysis of Twitter communication in emergency medicine. Park J, Probst M, Kea B, Chang BP. Am J Emerg Med. 2020 Jan 28. pii: S0735-6757(20)30052-8. doi: 10.1016/j.ajem.2020.01.052. [Epub ahead of print] No abstract available. PMID: 32035687
Envisioning the Future of Academic Writing. Yarris LM, Artino AR Jr, Deiorio NM, Ten Cate O, Sullivan GM, Simpson D. J Grad Med Educ. 2020 Feb;12(1):1-6. doi: 10.4300/JGME-D-20-00006.1. No abstract available. PMID: 32089790
Adolescent Intentional Ingestions in a Community Hospital. Jones MJ, Lin AL, Marshall RD, Sheridan DC. Hosp Pediatr. 2020 Feb;10(2):138-146. doi: 10.1542/hpeds.2019-0194. PMID: 31980442
Comparison of Male and Female Resident Milestone Assessments During Emergency Medicine Residency Training: A National Study. Santen SA, Yamazaki K, Holmboe ES, Yarris LM, Hamstra SJ. Acad Med. 2020 Feb;95(2):263-268. doi: 10.1097/ACM.0000000000002988. PMID: 31517688
Frequency of Abnormal and Critical Laboratory Results in Older Patients Presenting to the Emergency Department With Syncope. Moore AB, Su E, Weiss RE, Yagapen AN, Malveau SE, Adler DH, Bastani A, Baugh CW, Caterino JM, Clark CL, Diercks DB, Hollander JE, Nicks BA, Nishijima DK, Shah MN, Stiffler KA, Storrow AB, Wilber ST, Sun BC. Acad Emerg Med. 2020 Feb;27(2):161-164. doi: 10.1111/acem.13906. Epub 2020 Jan 7. No abstract available. PMID: 31837233
Modeling the impact of ventilations on the capnogram in out-of-hospital cardiac arrest. Gutiérrez JJ, Ruiz JM, Ruiz de Gauna S, González-Otero DM, Leturiondo M, Russell JK, Corcuera C, Urtusagasti JF, Daya MR. PLoS One. 2020 Feb 5;15(2):e0228395. doi: 10.1371/journal.pone.0228395. eCollection 2020. PMID: 32023298
Time-to-completed-imaging, survival and function in patients with spinal epidural abscess: Description of a series of 34 patients, 2015-2018. King C, Fisher C, Brown PCM, Priest KC, Tanski M, Sullivan P. BMC Health Serv Res. 2020 Feb 14;20(1):119. doi: 10.1186/s12913-020-4973-5. PMID: 32059715
Sudden Cardiac Death as First Manifestation of Heart Disease in Women: The Oregon Sudden Unexpected Death Study, 2004-2016. Reinier K, Stecker EC, Uy-Evanado A, Chugh HS, Binz A, Nakamura K, Sargsyan A, Jui J, Chugh SS. Circulation. 2020 Feb 18;141(7):606-608. doi: 0.1161/CIRCULATIONAHA.119.044169. Epub 2020 Feb 17. No abstract available. PMID: 32065764
It is with a heavy heart that we announce the passing of our esteemed colleague, Dana Zive, Sunday, September 30, 2018.
Dana was the Director of the Oregon POLST Registry, Associate Director of the OHSU Center for Ethics in Health Care, and a Research Assistant Professor in the OHSU Department of Emergency Medicine and CPR-EM. She earned her B.S. in Environmental Chemistry and Toxicology at the University of Nevada, Reno, and her M.P.H. in Public Health Education and Biostats/Epidemiology from San Jose State University. Dana joined OHSU in 2004, and her areas of focus included end-of-life care and emergency care research.
Dana was integrally involved in many DEM research efforts, including the Resuscitation Outcomes Consortium (many out-of-hospital interventional trials in cardiac arrest and trauma) and the Physician Orders for Life-Sustaining Treatment Program (POLST). She was key in developing and implementing the Oregon electronic POLST registry, including legislated state funding. Dana has been a fundamental member of CPREM throughout our years of building infrastructure and growth. She had a true research mind and a passion for data. She was our colleague and friend and will be dearly missed.
Dana is survived by her husband and daughter (Lola, 8). If you have a story about Dana you would like to share with her family, please send your thoughts to cookjen@ohsu.edu