Center for Policy and Research in Emergency Medicine (CPR-EM)

The OHSU Center for Policy and Research in Emergency Medicine's breakthrough research leads to new standards of care and a better understanding of important issues involving emergency medicine, disaster preparedness, and toxicology.

The CPR-EM was established to promote several long-term goals:

  1. Partner with policy-makers locally, state-wide and nationally, in identifying areas in which high-quality research can contribute to important health policy issues.
  2. Increase the contribution of Emergency Medicine faculty members to important health policy issues facing our community, our state and our nation.
  3. Enhance the research activities of the Department of Emergency Medicine, seeking external funding to facilitate this goal.

In the Media

Craig Newgard

“Oregon Emergency Care Research Multidisciplinary Training Program”

Sponsor: National Heart, Lung, and Blood Institute (NHLBI), National Institute of Mental Health (NIMH), National Institute of Nursing Research (NINR) - 1K12HL133115

Award Dates: 08/15/16-06/30/21

Role: Principal Investigator

“The Value of Pediatric Readiness in the Emergency Care of Injured Children”

Sponsor: Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHHD) - 1R24HD085927

Award Dates: 09/30/17-06/30/22

Role: Principal Investigator

“A Multi-State Evaluation of Emergency Department Pediatric Readiness: Guideline Uptake and Association with Quality, Outcomes, and Cost”

Sponsor: Health Resources and Services Administration (HRSA) Maternal and Child Health Bureau - 1H34MC332430100

Award Dates: 09/01/19-08/31/23

Role: Principal Investigator

“Comparative Effectiveness of Trauma Center Care for Older Americans”

Sponsor: Brigham and Women's Hospital Inc (BWH) via National Institute on Aging (NIA) - 1R56AG048452-01A1

Award Dates: 09/30/17-08/31/19

Role: Site Principal Investigator / Co-Investigator

Additional emergency medicine research statistics can be found on the OHSU Research Expertise website. 
 

Esther Choo

“Implementation, Outcomes, and Cost of a Novel Medicaid Policy to Reduce
Opioids for Back Pain”

Sponsor: National Institute on Drug Abuse (NIDA) - 1R01DA044284

Award Dates: 08/15/18-05/31/23

Role: Principal Investigator

“Risk of Motor Vehicle Crashes from Cannabis Use in Emergency Department
Patients”

Sponsor: Insurance Institute for Highway Safety (IIHS)

Award Dates: 11/01/16-04/30/20

Role: Principal Investigator

“Virtual Coaching in Making Informed Choices on Elder Abuse/Neglect Self-Disclosure (VOICES)”

Sponsor: Yale University via NIA - 1R01AG060084

Award Dates: 09/01/18-08/31/22

Role: Site Principal Investigator / Co-Investigator

Matthew Hansen

“Improving the Safety and Efficacy of Out-of-Hospital Pediatric Airway Management”

Sponsor: National Heart, Lung, and Blood Institute - 1K23HL131440

Award Dates: 09/26/16-08/31/20

Role: Principal Investigator

“Charlotte, Houston, and Milwaukee Prehospital (CHaMP) Research Node”

Sponsor: Health Resources and Services Administration (HRSA) Bureau of Health Professions - 5H34MC26201

Award Dates: 09/01/17-08/31/20

Role: Site Principal Investigator / Co-Investigator

“The Charlotte, Houston, and Milwaukee Prehospital (CHaMP) Research Node”

Sponsor: Health Resources and Services Administration (HRSA) Maternal and Child Health Bureau - U03MC33154

Award Dates: 09/01/19-08/31/23

Role: Site Principal Investigator / Co-Investigator

Bory Kea

“Optimal Anticoagulation Strategies for Acute Atrial Fibrillation”

Sponsor: National Heart, Lung, and Blood Institute - 1K08HL140105

Award Dates: 12/15/17-11/30/20

Role: Principal Investigator

“Specimen Collection in the Emergency Department for the Assessment of Clinical Performance of the Siemens PBNP Assay”

Sponsor: Siemens Healthcare Diagnostics

Award Dates: 06/12/19-06/30/22

Role: Principal Investigator

“BUILD EXITO Y6”

Sponsor: EXITO Institutional Core

Award Dates: 11/01/19-06/30/20

Role: Principal Investigator

“VITROS® Immunodiagnostic Products hs Troponin I US Sample Collection Protocol”

Sponsor: Ortho-Clinical Diagnostics Inc

Award Dates: 06/18/18-06/30/21

Role: Principal Investigator

Brandon Maughan

“Sex-Based Differences in Risk Stratification and Diagnostic Imaging for Diagnosis of Pulmonary Embolism”

Sponsor: Oregon Emergency Care Research Multidisciplinary Training Program - National Heart, Lung, and Blood Institute - 5K12HL133115

Award Dates: 07/01/18-08/30/21

Role: Scholar

David Sheridan

“West Coast Consortium for Technology and Innovation in Pediatrics”

Sponsor: Children's Hospital Los Angeles (CHLA) via FDA - 1P50FD006425

Award Dates: 09/01/18-08/31/23

Role: Site Principal Investigator / Co-Investigator

“Solace: A Wearable Continuous Early Suicide Warning System for Adolescents”

Sponsor: Oregon Emergency Care Research Multidisciplinary Training Program

National Institute of Mental Health / National Heart, Lung, and Blood Institute - 5K12HL133115

Award Dates: 07/01/18-06/30/21

Role: Scholar

“SRA-19-145 ProMedix, Inc.”

Sponsor: ProMedix, Inc.

Award Dates: 08/01/19-07/31/20

Role: Principal Investigator

“Physiologic Parameters Related to Suicidality in Adolescent Mental Health”

Sponsor: Welch Allyn

Award Dates: 01/01/19-01/31/22

Role: Principal Investigator

Andrew Moore

“A Randomized Controlled Trial of Usual Care Plus Mobile Cardiac Telemetry Versus Usual Care Alone for Unexplained Syncope in Older Adults Evaluated in the Emergency Department”

Sponsor: Medical Research Foundation (MRF) Early Clinical Investigator (ECI) Award

Award Dates: 04/01/20-03/31/21

Role: Principal Investigator

Mohamud Daya

Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) -
Network Clinical Center (Award Hub)”

Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) - 1U24NS100657

Award Dates: 07/15/17-05/31/22

Role: Principal Investigator

“Characterizing Prehospital Delay and Outcomes in Patients Treated for Potential Acute Coronary Syndrome in the Emergency Department”

Sponsor: University of California, Los Angeles (UCLA) via National Heart, Lung, and Blood Institute - 1R21HL140277

Award Dates: 08/01/18-07/31/20

Role: Site Principal Investigator / Co-Investigator

There is a lot going on in our Emergency Department! And with the expansion in hospitals, we welcome Adventist, Tuality, and CMH to the team, and hope the other sites will consider future research opportunities. Thank you for your continued support to make these trials successful. Each, and every one of you, are needed to move the needle of science forward as we provide high-quality healthcare.

- Bory Kea, MD, MCR, FACEP - Director of Clinical Trial, Department of Emergency Medicine

Heart Failure Pro BNP Study

Evaluating a new pro-BNP assay in patients with heart failure (for diagnosis and severity assessment)

PI: Dr. Kea; Coordinator: Joy Kim

Inclusion criteria: >21 yo, with SOB and/or edema; enrollment within 11hrs of presentation

Exclusion: Trauma, on dialysis, prisoner, homelessness, and prior enrollment

Enrollment-to-date: 56

Site Goal: 100 (enrollment period through February 2020)

Digital Capillary Refill with HydraSense

Using a novel device (Hydrasense) to compare manual vs digital capillary refill: currently enrolling in patients 6mo-65yo.

PI: Dr. Sheridan; Coordinator: Nancy Le

Enrollment-to-date: 184

Goal: 600 until October

HydraSense for Sepsis

A novel device for distal perfusion: currently enrolling in patients 6mo-65yo with fever, sepsis, and ESI 2-3.

  • PI: David Sheridan; Coordinator: Nancy Le
  • Enrollment-to-date: 15

Enrollment Goal: 100

Solace

Wearable technology for physiologic monitoring of adolescent suicidality: enrolls adolescents presenting with suicidality with goal of developing objective/physiologic markers that correlate with escalating suicidality

PI: Dr. Sheridan; Coordinator: Nancy Le

Enrollment-to-date: 67

Goal: 200 across the pediatric ER and inpatient adolescent psychiatric unit at Unity

BOOST-3 Brain Oxygen Optimization in Severe TBI Phase-3 Trial

BOOST 3 is a trial being run through the nationwide SIREN Network. OHSU is an “award hub”, and 4 of our OHSU network sites will also be participating in this trial (OSU, Duke, University of Utah, and University of Rochester Medical Center).  A total of 45 sites will be enrolling patients throughout the duration of this trial. BOOST 3 will operate under EFIC (Exception from Informed Consent) rules, and is currently conducting public disclosure activities, and final team training.

PI: Dr. Daya, ED Coordinator: Jenny Cook;

Trauma Research Group Coordinators: Samantha Underwood & Keeley McConnell

Registered with ClinicalTrials.gov: NCT03754114

Status: Pre-study preparations

Enrollment is expected to begin in January 2020 at OHSU.

Learn more here

ICECAP- Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (a SIREN Network Study)

OHSU will enroll patients locally at Portland Adventist and OHSU. Additionally, OHSU is anticipating that 5-6 of its network partners will also be conducting ICECAP. 

  • PI: Daya Coordinator: Nancy Le
  • Status: Pre-study Preparation

Launch: Spring 2020

Learn more here.

ICU-ED Sepsis Studies

Questions for ICU team?

  • Contact our study team Smartweb à Last Name à PRISM (#11912) (8am to 9pm)

Site PI Akram Khan (khana@ohsu.edu) pager à 15351 or text/cell 503-449-4314 (24 hours).

VICTAS

Giving vitamin C, thiamine, and steroids in patients with septic shock or respiratory failure from sepsis (ventilator, BiPAP, HFNC dependent)

PI: Akram Khan; Bory Kea

Site Enrollment: 23

Status: Closed to enrollment (as of 8/7/19 - check back for updates)

Total Enrollment Goal of 500 REACHED across 43 sites

CLOVERS

Using liberal fluid strategy vs early vasopressor strategy in patients with Septic Shock (sepsis + hypotension)

PI: Akram Khan, Co-I: Bory Kea

Site Enrollment: 104

Site Goal: 146 April 2021 (1 per week)

Total Enrollment Goal: 2200 until April 2021

IVY

Multi-center observational study evaluating the efficacy of influenza vaccines among critically ill and hospitalized patients

  • PI: Akram Khan
  • Site Enrollment: 58
  • Site Goal: 100 until March 2020 (5 per week)

Total Enrollment Goal: 700 until March 2020 

CLOSED STUDY: ESETT- Established Status Epilepticus Treatment Trial (a NETT Network study)

The ESETT Trial was conducted at OHSU from November 2015-June 2018, and OHSU enrolled 9 subjects locally, and 2 at our satellite site in Utah.

Visit our NETT Study page for more information

Recent Publications

Stroke Prophylaxis for Atrial Fibrillation? To Prescribe or Not to Prescribe-A Qualitative Study on the Decisionmaking Process of Emergency Department Providers. Kea B, Alligood T, Robinson C, Livingston J, Sun BC. Ann Emerg Med. 2019 Dec;74(6):759-771. doi: 10.1016/j.annemergmed.2019.03.026. Epub 2019 May 9. PMID: 31080035

In reply. Coates WC, Yarris LM, Clarke SO, Runde DP, Fowlkes E, Kurth J, Jordan J. Ann Emerg Med. 2019 Dec;74(6):825-826. doi: 10.1016/j.annemergmed.2019.07.002. No abstract available. PMID: 31779961

Inclusion of All Patients Admitted for Trauma in Trauma Registries-Reply. Newgard CD, Bulger EM. JAMA Surg. 2019 Dec 4. doi: 10.1001/jamasurg.2019.4941. [Epub ahead of print] No abstract available. PMID: 31800006

Relationship Between Duration of Targeted Temperature Management, Ischemic Interval, and Good Functional Outcome From Out-of-Hospital Cardiac Arrest. Sawyer KN, Humbert A, Leroux BG, Nichol G, Kudenchuk PJ, Daya MR, Grunau B, Wang HE, Ornato JP, Rittenberger JC, Aufderheide TP, Wittwer L, Colella MR, Austin M, Kawano T, Egan D, Richmond N, Vithalani VD, Scales D, Baker AJ, Morrison LJ, Vilke GM, Kurz MC; Resuscitation Outcomes Consortium. Crit Care Med. 2019 Dec 10. doi: 10.1097/CCM.0000000000004160. [Epub ahead of print] PMID: 31821187

Frequency of Abnormal and Critical Laboratory Results in Older Patients Presenting to the Emergency Department With Syncope. Moore AB, Su E, Weiss RE, Yagapen AN, Malveau SE, Adler DH, Bastani A, Baugh CW, Caterino JM, Clark CL, Diercks DB, Hollander JE, Nicks BA, Nishijima DK, Shah MN, Stiffler KA, Storrow AB, Wilber ST, Sun BC. Acad Emerg Med. 2019 Dec 14. doi: 10.1111/acem.13906. [Epub ahead of print] No abstract available. PMID: 31837233

Health Care Expenditures Among Adults With Diabetes After Oregon's Medicaid Expansion. Lindner SR, Marino M, O'Malley J, Angier H, Bailey SR, Hoopes M, Springer R, McConnell KJ, DeVoe J, Huguet N. Diabetes Care. 2019 Dec 19. pii: dc191343. doi: 10.2337/dc19-1343. [Epub ahead of print] PMID: 31857442

The impact of a pediatric emergency department discharge take-home antibiotic program on patient satisfaction. Robertson CR, Ran R, Wong JT, Nguyen L, Burns B, Mah ND. Am J Emerg Med. 2019 Dec 20. pii: S0735-6757(19)30846-0. doi: 10.1016/j.ajem.2019.12.039. [Epub ahead of print] No abstract available. PMID: 31889576

Accuracy of Hospital Discharge Codes in Medicare Claims for Knee and Hip Replacement Patients. Kim H, Grunditz JI, Meath THA, Quiñones AR, Ibrahim SA, McConnell KJ. Med Care. 2020 Jan 7. doi: 10.1097/MLR.0000000000001290. [Epub ahead of print] PMID: 31914103

Variation in Bystander Cardiopulmonary Resuscitation Delivery and Subsequent Survival From Out-of-Hospital Cardiac Arrest Based on Neighborhood-Level Ethnic Characteristics. Blewer AL, Schmicker RH, Morrison LJ, Aufderheide TP, Daya M, Starks MA, May S, Idris AH, Callaway CW, Kudenchuk PJ, Vilke GM, Abella BS; Resuscitation Outcomes Consortium Investigators. Circulation. 2020 Jan 7;141(1):34-41. doi: 10.1161/CIRCULATIONAHA.119.041541. Epub 2019 Dec 30. PMID: 31887076

Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus. NEJM. 2019; 381;22. (November 28, 2019)

More EM Faculty Publications

Dana Zive

It is with a heavy heart that we announce the passing of our esteemed colleague,  Dana Zive, Sunday, September 30, 2018.

 Dana was the Director of the Oregon POLST Registry, Associate Director of the OHSU Center for Ethics in Health Care, and a Research Assistant Professor in the OHSU Department of Emergency Medicine and CPR-EM.  She earned her B.S. in Environmental Chemistry and Toxicology at the University of Nevada, Reno, and her M.P.H. in Public Health Education and Biostats/Epidemiology from San Jose State University.  Dana joined OHSU in 2004, and her areas of focus included end-of-life care and emergency care research. 

 Dana was integrally involved in many DEM research efforts, including the Resuscitation Outcomes Consortium (many out-of-hospital interventional trials in cardiac arrest and trauma) and the Physician Orders for Life-Sustaining Treatment Program (POLST).  She was key in developing and implementing the Oregon electronic POLST registry, including legislated state funding. Dana has been a fundamental member of CPREM throughout our years of building infrastructure and growth.  She had a true research mind and a passion for data. She was our colleague and friend and will be dearly missed. 

Dana is survived by her husband and daughter (Lola, 8).   If you have a story about Dana you would like to share with her family, please send your thoughts to cookjen@ohsu.edu