Molecular

The functioning of cells in the nervous system is dependent on a large number of molecules such as enzymes, receptors, transporters, neurotransmitters, channels, RNA, DNA and second messengers. Molecular neuroscientists are interested in determining how the expression of these molecules is regulated, how these molecules work and how they interact with other molecules to regulate cellular function. Techniques used to study molecular function include gene cloning and nucleic acid sequence analysis, protein purification and analysis of protein structure and function, determination of protein-protein and protein-nucleic acid interactions, biophysical analysis of ion channels in neurons or expressed in heterologous cells, kinetic analysis of radioligand binding, mapping gene regulatory networks and signal transduction pathways, and generation of transgenic species.

Areas of strength within the molecular subdiscipline are:

For more information on NGP faculty involved in this research, click on the links to these investigators.

    • Faculty Appointments

      • Professor of Molecular Microbiology and Immunology, School of Medicine
    • Areas of interest

      • host-pathogen interactions, neural-immune communications, neuroinflammation, infections, bacterial pathogenesis, organismal response to infections
    • Faculty Appointments

      • Professor of Anesthesiology and Perioperative Medicine, School of Medicine
    • Faculty Appointments

      • Professor, Oregon Institute of Occupational Health Sciences
      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Circadian Rhythms
      • Sleep
      • Synaptic Transmission
      • Suprachiasmatic Nucleus
      • Neural Network Activity
    • Faculty Appointments

      • Professor of Physiology and Pharmacology, School of Medicine
    • Areas of interest

      • autonomic
      • electrophysiology
      • synaptic transmission
    • Faculty Appointments

      • Professor of Pediatrics, School of Medicine
    • Faculty Appointments

      • Assistant Professor, Vollum Institute
    • Areas of interest

      • x-ray crystallography and electrophysiology
      • cryo-electron microscopy (cryo-EM)
      • sodium channels
      • ion channels
      • channel assembly, channel gating, and ion selectivity
      • protein biochemistry
      • structural biology
    • Faculty Appointments

      • Assistant Professor of Medicine, Division of Cardiovascular Medicine, School of Medicine
    • Areas of interest

      • Brain Development, Radial Glia, Neuronal Polarity, Endothelial heterogeneity, Single Cell Transcriptome/Proteome Analysis
    • Faculty Appointments

      • Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
    • Areas of interest

      • Hair-cell transduction
      • Hair-bundle development
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • zebrafish genetics
      • electrophysiology
      • ion channel function
      • imaging
    • Faculty Appointments

      • Associate Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
      • Associate Professor of Cell, Developmental and Cancer Biology, School of Medicine
    • Areas of interest

      • Fate of otic epithelial progenitors in the mouse otic vesicle
      • Lineage relationships of sensory and nonsensory cells in the mouse inner ear
      • Molecular regulation of sensory organ formation
    • Faculty Appointments

      • Associate Professor of Physiology and Pharmacology, School of Medicine
    • Areas of interest

      • developmental
      • Neurobiology of Disease
      • biology
      • developmental neurobiology
      • nervous system
      • neurodegeneration
      • neuroscience
      • signal transduction
      • cell migration
      • cell adhesion
      • in vivo imaging
      • embryogenesis
      • embryology
      • Ephrins
      • Eph receptors
      • Ig-CAMs
      • G proteins
      • non-receceptor tyrosine kinases
      • Amyloid Precursor Protein
      • biology of aging
    • Faculty Appointments

      • Associate Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
    • Areas of interest

      • Representation of speech and other natural sounds in auditory cortex
      • Learning and attention-driven changes in auditory representation
      • Biological mechanisms underlying neural computations
    • Faculty Appointments

      • Assistant Professor of Neurology, School of Medicine
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • glia
      • axon
      • Wallerian degeneration
      • neuron-glia signaling
      • astrocytes
      • neurodegeneration
      • Drosophila
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • metabolic regulation of gene expression
      • characterization of activity-regulated genes
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • chemical synapses and synaptic transmission
      • glutamate receptors
      • neurotransmitter transporters
      • ligand-gated ion channels
      • cryo-electron microscopy (cryo-EM)
      • x-ray crystallography
      • membrane proteins
    • Faculty Appointments

      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Astrocytes
      • Glia
      • Fetal alcohol spectrum disorders
      • Neuronal development
      • Extracellular matrix
      • Neurite outgrowth
      • Chondroitin sulfate proteoglycans
    • Faculty Appointments

      • Professor of Chemical Physiology and Biochemistry, School of Medicine
      • Professor of Anesthesiology and Perioperative Medicine, School of Medicine
      • Professor of Medicine, Division of Cardiovascular Medicine, School of Medicine
    • Faculty Appointments

      • Professor of Neurological Surgery, School of Medicine
    • Faculty Appointments

      • Professor of Psychiatry, School of Medicine
      • Professor of Behavioral Neuroscience, School of Medicine
    • Faculty Appointments

      • Professor of Neurology, School of Medicine
    • Faculty Appointments

      • Professor of Physiology and Pharmacology, School of Medicine
    • Faculty Appointments

      • Professor of Pediatrics, School of Medicine
    • Areas of interest

      • neurodevelopment
      • neurogenesis
      • cell fate specification
      • histone modifiers
      • epigenetics
      • gene regulation
    • Faculty Appointments

      • Associate Professor of Neurology, School of Medicine
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • Rett Syndrome
      • neuronal-glial interactions
      • microRNA
      • epigenetics
      • neurogenesis
      • neuronal circuitry
      • neurodevelopment
    • Faculty Appointments

      • Associate Professor, Vollum Institute
    • Areas of interest

      • basal ganglia circuit analysis
      • cortical-subcortical interactions
      • optogenetics
      • genetically engineered calcium indicators
      • two-photon calcium imaging
    • Faculty Appointments

      • Professor of Pediatrics, School of Medicine
    • Areas of interest

      • patient resiliency
      • cachexia
      • failure to thrive
      • fatigue
    • Faculty Appointments

      • Professor of Obstetrics and Gynecology, School of Medicine
    • Faculty Appointments

      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Neuroethology
      • Molecular neuroscience
      • Speech and Language
      • Vocal learning
      • Central auditory processing
      • Learning and memory
      • Neurogenomics
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • Glial cell biology
      • Neuron-glial interactions
      • Glial-glial interactions
      • Myelination and remyelination
      • Zebrafish
    • Faculty Appointments

      • Professor of Molecular and Medical Genetics, School of Medicine
      • Professor of Molecular Microbiology and Immunology, School of Medicine
    • Faculty Appointments

      • Associate Professor of Cell, Developmental and Cancer Biology, School of Medicine
    • Areas of interest

      • zebrafish axonal transport neuron development lateral line sensory systems
    • Faculty Appointments

      • Research Associate Professor of Ophthalmology, School of Medicine
      • Professor, Oregon National Primate Research Center
    • Areas of interest

      • Retinal degenerative disease
      • Nutritional factors in development and aging of the retina and brain
      • Gene and cell therapies for retinal disease
      • Cognitive aging
    • Faculty Appointments

      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Dopamine receptors
      • Signal transduction
      • Cellular and molecular biology of g protein-coupled receptors
      • Structure-function analysis of dopamine receptors
      • Behavior
    • Faculty Appointments

      • Associate Professor of Molecular and Medical Genetics, School of Medicine
    • Areas of interest

      • Autism
      • Neurodevelopmental disorders
      • Genetics/genomics
      • Stem cells
      • Developmental neuroscience
    • Faculty Appointments

      • Professor of Physiology and Pharmacology, School of Medicine
    • Faculty Appointments

      • Professor of Physiology and Pharmacology, School of Medicine
    • Faculty Appointments

      • Professor of Anesthesiology and Perioperative Medicine, School of Medicine
      • Professor of Molecular and Medical Genetics, School of Medicine
    • Faculty Appointments

      • Associate Professor of Anesthesiology and Perioperative Medicine, School of Medicine
    • Faculty Appointments

      • Professor of Biochemistry and Molecular Biology, School of Medicine
    • Areas of interest

      • Ion channel regulation, insulin secretion regulation in health and disease, pancreatic beta-cell biology and signaling, pharmacological chaperones, structural biology of potassium channels
    • Faculty Appointments

      • Professor of Medicine, Division of Pulmonary and Critical Care Medicine, School of Medicine
      • Professor of Physiology and Pharmacology, School of Medicine
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • small G proteins
      • MAP kinase
      • B-Raf
    • Faculty Appointments

      • Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
    • Areas of interest

      • Brainstem circuits that process acoustic signals
      • Synaptic physiology: How do cells and synapses preserve information provided by the ear?
    • Faculty Appointments

      • Professor of Behavioral Neuroscience, School of Medicine
      • Professor of Physiology and Pharmacology, School of Medicine
      • Professor, Oregon National Primate Research Center
    • Areas of interest

      • Aging
      • Circadian rhythms
      • Neuroendocrinology
      • Puberty
    • Faculty Appointments

      • Associate Professor of Physiology and Pharmacology, School of Medicine
    • Areas of interest

      • Ion conduction and gating in K+ channels
    • Faculty Appointments

      • Professor, Vollum Institute
      • Professor of Physiology and Pharmacology, School of Medicine
    • Areas of interest

      • exocytosis and endocytosis of synaptic vesicles
      • short and long-term plasticity in the retina and brainstem
      • electrophysiology of auditory pathway
      • ribbon synapses
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • neurogenesis
      • hippocampal microcircuits
      • glutamate receptors
      • epilepsy
      • regeneration and repair
      • synaptic transmission
    • Faculty Appointments

      • Assistant Professor, Vollum Institute
    • Areas of interest

      • x-ray crystallography
      • ion channels and transporters
      • structural biology
      • signal transduction
      • membrane proteins
      • electrophysiology
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • opiate desensitization and tolerance
      • receptor trafficking
      • dendrodendritic transmission
    • Faculty Appointments

      • Assistant Professor, Vollum Institute
    • Areas of interest

      • neurodevelopment
      • axon guidance
      • neuronal migration
      • synaptogenesis
      • neural circuitry
    • Faculty Appointments

      • Associate Professor, Vollum Institute
    • Areas of interest

      • photoactivated localization microscopy (PALM)
      • two-photon fluorescence lifetime imaging microscopy (2PFLIM)
      • fluorescence resonance energy transfer (FRET) microscopy
      • protein and signaling dynamics during plasticity
      • in vivo imaging of neuromodulation and subcellular signaling in awake animals