Kevin Wright, Ph.D.

Kevin Wright, PhD

Scientist, Vollum Institute


After earning his B.S. in Neuroscience from Allegheny College in 2001, Wright received his Ph.D. in Neurobiology from The University of North Carolina, Chapel Hill in 2006. He did his postdoctoral training at Johns Hopkins Medical Institute. In 2013 Wright joined the Vollum Institute as an assistant scientist and was promoted to scientist in 2020.

Summary of current research

Our ability to perceive of the world around us begins with primary sensory circuits. The neurons within these circuits have an astonishing level of diversity in their molecular properties, morphology and physiological function. Our group uses both the mouse dorsal root ganglia and retina as model systems to investigate how neurons are organized into functional circuits during development. In the somatosensory system, the dorsal root ganglia (DRG) contains at least 18 distinct primary somatosensory neuron subtypes convey information from the periphery to the central nervous system. DRG sensory neurons have a peripheral axon that forms specialized endings within the skin and an axon that synapses onto interneurons within the dorsal spinal cord. Of particular interest to the lab are the low threshold mechanoreceptors (LTMRs), which convey our sense of touch. Each LTMR subtype has a stereotyped morphology, connectivity pattern, and response properties that directly relate to the type of stimulus it conveys. In the mammalian visual system, the retina contains more than 100 distinct neuronal subtypes, each playing a specific role in the processing of visual information. The majority of this processing occurs within the inner plexiform layer of the retina, where the synaptic connections between 15 types of bipolar cells (BCs), >35 types of retinal ganglion cells (RGCs), and >35 types of amacrine cells (ACs) are all formed and precisely organized.

To investigate how somatosensory and retinal circuits develop, we utilize molecular–genetic approaches to answer the following questions:

  • How are peripheral receptive fields and central projections of LTMRs established and organized during development?
  • What are the molecular pathways that organize the axons and dendrites of >85 different retinal neurons within a space that is less than 60 microns wide?
  • Using genetic approaches, how can we identify and manipulate individual neuron subtypes to understand their function?
  • How are the development and function of somatosensory and retinal circuits affected in neurodevelopmental disorders?

Selected publications

Jahncke JN, Miller DS, Krush M, Schnell E, Wright KM. (2024) Inhibitory CCK+ basket synapse defects in mouse models of dystroglycanopathy. Elife. 12:RP87965.

Berry MH, Moldavan M, Garrett T, Meadows M, Cravetchi O, White E, Leffler J, von Gersdorff H, Wright KM, Allen CN & Sivyer B. (2023) A melanopsin ganglion cell subtype forms a dorsal retinal mosaic projecting to the supraoptic nucleus. Nature communications. 14.1.1492.

Pomaville MB & Wright KM. (2023) Follicle-innervating Aδ-low threshold mechanoreceptive neurons form receptive fields through homotypic competition. Neural Development. 18.1.2.

Co M, Barnard RA, Jahncke JN, Grindstaff S, Fedorov LM, Adey AC, Wright KM & O’Roak BJ. (2022) Shared and Distinct Functional Effects of Patient-Specific Tbr1 Mutations on Cortical Development. Journal of Neuroscience. 42.37.p.7166-7181.16p.

Miller DS & Wright KM. (2021) Neuronal Dystroglycan regulates postnatal development of CCK/cannabinoid receptor-1 interneurons. Neural Development. 16.1.4.

Kerstein PC, Leffler J, Sivyer B, Taylor WR, Wright KM. (2020) Gbx2 identifies two amacrine cell subtypes with distinct molecular, morphological, and physiological properties. Cell Reports 33:108382.

Lindenmaier LB, Parmentier N, Guo C, Tissir F, Wright KM. (2019) Dystroglycan is a scaffold for extracellular axon guidance decisions. eLife 8. pii:e42143.

Clements R, Wright KM. (2018) Retinal ganglion cell axon sorting at the optic chiasm requires dystroglycan. Dev. Biol. 442:210-219.

Clements R, Turk R, Campbell KP, Wright KM. (2017) Dystroglycan maintains inner limiting membrane integrity to coordinate retinal development. J. Neurosci. 37:8559-8574.

Wright KM, Lyon K, Leung H, Leahy DJ, Ma L, Ginty DD. (2012) Dystroglycan organizes axon guidance cue localization and axonal pathfinding. Neuron 76:931-944.