Cellular

Speed is a defining characteristic of the nervous system; understanding its basis is the primary goal of cell neurobiology. When you see an event, you think that you see it the instant it happens. But what do you mean by an "instant?" It is a time so brief that we could not tell if something happened sooner; it is a time determined by the speed of the nervous system. During that instant, a series of neurons, conversing at synapses, are activated sequentially and they each transmit a signal, called an action potential, over long distances. Action potentials and synaptic transmission are controlled by membrane proteins called ion channels. The energy source is the array of transmembrane ionic gradients maintained by proteins called ion pumps.

These channels and pumps are the molecular targets of research in cell neurobiology. The goals of those studying cellular neuroscience are to describe the structural properties of these channels and pumps, the basis of their chemical and electrical control mechanisms, their function on individual neurons and synapses, and their spatial localization on cells. Methods include microelectric recordings from individual cells, advanced microscopic methods, immunocytochemistry, and the biochemical and molecular methods common to all studies of protein function.

Areas of strength within the cellular subdiscipline are:

For more information on NGP faculty involved in this work, click on the links to these investigators.

    • Faculty Appointments

      • Professor of Molecular Microbiology and Immunology, School of Medicine
    • Areas of interest

      • host-pathogen interactions, neural-immune communications, neuroinflammation, infections, bacterial pathogenesis, organismal response to infections
    • Faculty Appointments

      • Professor, Oregon Institute of Occupational Health Sciences
      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Circadian Rhythms
      • Sleep
      • Synaptic Transmission
      • Suprachiasmatic Nucleus
      • Neural Network Activity
    • Faculty Appointments

      • Professor of Physiology and Pharmacology, School of Medicine
    • Areas of interest

      • autonomic
      • electrophysiology
      • synaptic transmission
    • Faculty Appointments

      • Professor of Pediatrics, School of Medicine
    • Faculty Appointments

      • Assistant Professor, Vollum Institute
    • Areas of interest

      • x-ray crystallography and electrophysiology
      • cryo-electron microscopy (cryo-EM)
      • sodium channels
      • ion channels
      • channel assembly, channel gating, and ion selectivity
      • protein biochemistry
      • structural biology
    • Faculty Appointments

      • Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
    • Areas of interest

      • Hair-cell transduction
      • Hair-bundle development
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • zebrafish genetics
      • electrophysiology
      • ion channel function
      • imaging
    • Faculty Appointments

      • Associate Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
    • Areas of interest

      • Representation of speech and other natural sounds in auditory cortex
      • Learning and attention-driven changes in auditory representation
      • Biological mechanisms underlying neural computations
    • Faculty Appointments

      • Assistant Professor of Neurology, School of Medicine
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • glia
      • axon
      • Wallerian degeneration
      • neuron-glia signaling
      • astrocytes
      • neurodegeneration
      • Drosophila
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • chemical synapses and synaptic transmission
      • glutamate receptors
      • neurotransmitter transporters
      • ligand-gated ion channels
      • cryo-electron microscopy (cryo-EM)
      • x-ray crystallography
      • membrane proteins
    • Faculty Appointments

      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Astrocytes
      • Glia
      • Fetal alcohol spectrum disorders
      • Neuronal development
      • Extracellular matrix
      • Neurite outgrowth
      • Chondroitin sulfate proteoglycans
    • Faculty Appointments

      • Professor of Neurological Surgery, School of Medicine
    • Faculty Appointments

      • Professor of Neurology, School of Medicine
    • Faculty Appointments

      • Associate Professor of Neurology, School of Medicine
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • Rett Syndrome
      • neuronal-glial interactions
      • microRNA
      • epigenetics
      • neurogenesis
      • neuronal circuitry
      • neurodevelopment
    • Faculty Appointments

      • Associate Professor, Vollum Institute
    • Areas of interest

      • basal ganglia circuit analysis
      • cortical-subcortical interactions
      • optogenetics
      • genetically engineered calcium indicators
      • two-photon calcium imaging
    • Faculty Appointments

      • Professor of Obstetrics and Gynecology, School of Medicine
    • Faculty Appointments

      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Neuroethology
      • Molecular neuroscience
      • Speech and Language
      • Vocal learning
      • Central auditory processing
      • Learning and memory
      • Neurogenomics
    • Faculty Appointments

      • Assistant Professor of Medicine, Division of Cardiovascular Medicine, School of Medicine
      • Assistant Professor of Anesthesiology and Perioperative Medicine, School of Medicine
      • Assistant Professor of Neurology, School of Medicine
    • Areas of interest

      • Neuron-glial and glial-glial interactions
      • Reactive astrogliosis
      • Neurovascular coupling
      • Ischemic injury
      • Neurodegenerative disorders
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • Glial cell biology
      • Neuron-glial interactions
      • Glial-glial interactions
      • Myelination and remyelination
      • Zebrafish
    • Faculty Appointments

      • Professor of Molecular and Medical Genetics, School of Medicine
      • Professor of Molecular Microbiology and Immunology, School of Medicine
    • Faculty Appointments

      • Associate Professor of Anesthesiology and Perioperative Medicine, School of Medicine
    • Faculty Appointments

      • Professor, Oregon National Primate Research Center
    • Faculty Appointments

      • Professor of Biochemistry and Molecular Biology, School of Medicine
    • Areas of interest

      • Ion channel regulation, insulin secretion regulation in health and disease, pancreatic beta-cell biology and signaling, pharmacological chaperones, structural biology of potassium channels
    • Faculty Appointments

      • Professor of Medicine, Division of Pulmonary and Critical Care Medicine, School of Medicine
      • Professor of Physiology and Pharmacology, School of Medicine
    • Faculty Appointments

      • Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
    • Areas of interest

      • Brainstem circuits that process acoustic signals
      • Synaptic physiology: How do cells and synapses preserve information provided by the ear?
    • Faculty Appointments

      • Associate Professor of Physiology and Pharmacology, School of Medicine
    • Areas of interest

      • Unnatural amino acid mutagenesis of membrane proteins
      • Ion conduction and voltage gating in K+ channels
      • Transport mechanism in glutamate transporters
      • Folding of membrane proteins
    • Faculty Appointments

      • Professor, Vollum Institute
      • Professor of Physiology and Pharmacology, School of Medicine
    • Areas of interest

      • exocytosis and endocytosis of synaptic vesicles
      • short and long-term plasticity in the retina and brainstem
      • electrophysiology of auditory pathway
      • ribbon synapses
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • neurogenesis
      • hippocampal microcircuits
      • glutamate receptors
      • epilepsy
      • regeneration and repair
      • synaptic transmission
    • Faculty Appointments

      • Assistant Professor, Vollum Institute
    • Areas of interest

      • x-ray crystallography
      • ion channels and transporters
      • structural biology
      • signal transduction
      • membrane proteins
      • electrophysiology
    • Faculty Appointments

      • Professor, Vollum Institute
    • Areas of interest

      • opiate desensitization and tolerance
      • receptor trafficking
      • dendrodendritic transmission
    • Faculty Appointments

      • Associate Professor, Vollum Institute
    • Areas of interest

      • photoactivated localization microscopy (PALM)
      • two-photon fluorescence lifetime imaging microscopy (2PFLIM)
      • fluorescence resonance energy transfer (FRET) microscopy
      • CRISPR/Cas9-based gene editing
      • in vivo imaging of neuromodulation and subcellular signaling in awake animals
      • protein and signaling dynamics during plasticity, cAMP/protein kinase A (PKA) signaling, labeling of endogenous proteins
      • dopamine, striatum, mouse locomotion