Developmental

In order to generate a functional nervous system, many complex events must take place in the right temporal and spatial sequences. For example, a large number of neuronal and glial cell types must be generated, neuronal processes must find their targets, and the appropriate cell specific molecules must be expressed. Developmental neuroscientists are interested in determining how such processes occur and the mechanisms by which they are regulated. Approaches used to study the development of the nervous system include molecular cloning and analysis of DNA and RNA; gene transfection of isolated cells; the generation of transgenic mice to analyze the effects of specific genes; immunocytochemistry and situ hybridization to localize proteins; RNA cell and organ culture to analyze the behavior of isolated neurons and glia; biochemical purification of molecules that are essential for development; and surgical manipulation of embryonic tissues in vivo.

Areas of strength within the developmental subdiscipline are:

For more information on NGP faculty involved in this work, click on the links to these investigators.

    • Appointments and titles

      • Professor of Molecular Microbiology and Immunology, School of Medicine
    • Areas of interest

      • host-pathogen interactions, neural-immune communications, neuroinflammation, infections, bacterial pathogenesis, organismal response to infections
    • Appointments and titles

      • Professor, Oregon Institute of Occupational Health Sciences
      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Circadian Rhythms
      • Sleep
      • Synaptic Transmission
      • Suprachiasmatic Nucleus
      • Neural Network Activity
    • Appointments and titles

      • Professor of Physiology and Pharmacology, School of Medicine
    • Areas of interest

      • autonomic
      • electrophysiology
      • synaptic transmission
    • Appointments and titles

      • Professor of Pediatrics, School of Medicine
    • Appointments and titles

      • Assistant Professor of Medicine, Division of Cardiovascular Medicine, School of Medicine
    • Areas of interest

      • Brain Development, Radial Glia, Neuronal Polarity, Endothelial heterogeneity, Single Cell Transcriptome/Proteome Analysis
    • Appointments and titles

      • Professor, Vollum Institute
    • Areas of interest

      • zebrafish genetics
      • electrophysiology
      • ion channel function
      • imaging
    • Appointments and titles

      • Associate Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
      • Associate Professor of Cell, Developmental and Cancer Biology, School of Medicine
    • Areas of interest

      • Fate of otic epithelial progenitors in the mouse otic vesicle
      • Lineage relationships of sensory and nonsensory cells in the mouse inner ear
      • Molecular regulation of sensory organ formation
    • Areas of interest

      • developmental
      • Neurobiology of Disease
      • biology
      • developmental neurobiology
      • nervous system
      • neurodegeneration
      • neuroscience
      • signal transduction
      • cell migration
      • cell adhesion
      • in vivo imaging
      • embryogenesis
      • embryology
      • Ephrins
      • Eph receptors
      • Ig-CAMs
      • G proteins
      • non-receceptor tyrosine kinases
      • Amyloid Precursor Protein
      • biology of aging
    • Appointments and titles

      • Associate Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
    • Areas of interest

      • Representation of speech and other natural sounds in auditory cortex
      • Learning and attention-driven changes in auditory representation
      • Biological mechanisms underlying neural computations
    • Appointments and titles

      • Assistant Professor of Neurology, School of Medicine
    • Appointments and titles

      • Professor, Vollum Institute
    • Areas of interest

      • glia
      • axon
      • Wallerian degeneration
      • neuron-glia signaling
      • astrocytes
      • neurodegeneration
      • Drosophila
    • Appointments and titles

      • Professor, Vollum Institute
    • Areas of interest

      • metabolic regulation of gene expression
      • characterization of activity-regulated genes
    • Appointments and titles

      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Astrocytes
      • Glia
      • Fetal alcohol spectrum disorders
      • Neuronal development
      • Extracellular matrix
      • Neurite outgrowth
      • Chondroitin sulfate proteoglycans
    • Appointments and titles

      • Assistant Professor, Vollum Institute
      • Assistant Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • neurotransmitter release
      • short-term synaptic plasticity
      • neural circuits
      • presynaptic calcium sensors
    • Appointments and titles

      • Professor Emeritus of Neurology, School of Medicine
    • Appointments and titles

      • Professor of Physiology and Pharmacology, School of Medicine
    • Appointments and titles

      • Associate Professor of Neurology, School of Medicine
    • Appointments and titles

      • Professor, Vollum Institute
    • Areas of interest

      • Rett Syndrome
      • neuronal-glial interactions
      • microRNA
      • epigenetics
      • neurogenesis
      • neuronal circuitry
      • neurodevelopment
    • Appointments and titles

      • Associate Professor, Vollum Institute
    • Areas of interest

      • basal ganglia circuit analysis
      • cortical-subcortical interactions
      • optogenetics
      • genetically engineered calcium indicators
      • two-photon calcium imaging
    • Appointments and titles

      • Professor of Pediatrics, School of Medicine
    • Areas of interest

      • patient resiliency
      • cachexia
      • failure to thrive
      • fatigue
    • Appointments and titles

      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Neuroethology
      • Molecular neuroscience
      • Speech and Language
      • Vocal learning
      • Central auditory processing
      • Learning and memory
      • Neurogenomics
    • Appointments and titles

      • Assistant Professor of Medicine, Division of Cardiovascular Medicine, School of Medicine
      • Assistant Professor of Anesthesiology and Perioperative Medicine, School of Medicine
      • Assistant Professor of Neurology, School of Medicine
    • Areas of interest

      • Neuron-glial and glial-glial interactions
      • Reactive astrogliosis
      • Neurovascular coupling
      • Ischemic injury
      • Neurodegenerative disorders
    • Appointments and titles

      • Professor, Vollum Institute
    • Areas of interest

      • Glial cell biology
      • Neuron-glial interactions
      • Glial-glial interactions
      • Myelination and remyelination
      • Zebrafish
    • Appointments and titles

      • Associate Professor of Cell, Developmental and Cancer Biology, School of Medicine
    • Areas of interest

      • zebrafish axonal transport neuron development lateral line sensory systems
    • Appointments and titles

      • Research Associate Professor of Ophthalmology, School of Medicine
      • Professor, Oregon National Primate Research Center
    • Areas of interest

      • Retinal degenerative disease
      • Nutritional factors in development and aging of the retina and brain
      • Gene and cell therapies for retinal disease
      • Cognitive aging
    • Appointments and titles

      • Associate Professor of Molecular and Medical Genetics, School of Medicine
    • Areas of interest

      • Autism
      • Neurodevelopmental disorders
      • Genetics/genomics
      • Stem cells
      • Developmental neuroscience
    • Appointments and titles

      • Professor of Physiology and Pharmacology, School of Medicine
    • Appointments and titles

      • Professor of Physiology and Pharmacology, School of Medicine
    • Appointments and titles

      • Professor of Anesthesiology and Perioperative Medicine, School of Medicine
      • Professor of Molecular and Medical Genetics, School of Medicine
    • Appointments and titles

      • Professor, Oregon National Primate Research Center
    • Appointments and titles

      • Professor of Medicine, Division of Pulmonary and Critical Care Medicine, School of Medicine
      • Professor of Physiology and Pharmacology, School of Medicine
    • Appointments and titles

      • Professor of Otolaryngology - Head and Neck Surgery, School of Medicine
    • Areas of interest

      • Brainstem circuits that process acoustic signals
      • Synaptic physiology: How do cells and synapses preserve information provided by the ear?
    • Appointments and titles

      • Professor of Behavioral Neuroscience, School of Medicine
      • Professor of Physiology and Pharmacology, School of Medicine
      • Professor, Oregon National Primate Research Center
    • Areas of interest

      • Aging
      • Circadian rhythms
      • Neuroendocrinology
      • Puberty
    • Appointments and titles

      • Professor, Vollum Institute
      • Professor of Physiology and Pharmacology, School of Medicine
    • Areas of interest

      • exocytosis and endocytosis of synaptic vesicles
      • short and long-term plasticity in the retina and brainstem
      • electrophysiology of auditory pathway
      • ribbon synapses
    • Appointments and titles

      • Professor, Vollum Institute
    • Areas of interest

      • neurogenesis
      • hippocampal microcircuits
      • glutamate receptors
      • epilepsy
      • regeneration and repair
      • synaptic transmission
    • Appointments and titles

      • Professor, Vollum Institute
    • Areas of interest

      • opiate desensitization and tolerance
      • receptor trafficking
      • dendrodendritic transmission
    • Appointments and titles

      • Assistant Professor, Vollum Institute
    • Areas of interest

      • neurodevelopment
      • axon guidance
      • neuronal migration
      • synaptogenesis
      • neural circuitry
    • Appointments and titles

      • Associate Professor, Vollum Institute
    • Areas of interest

      • photoactivated localization microscopy (PALM)
      • two-photon fluorescence lifetime imaging microscopy (2PFLIM)
      • fluorescence resonance energy transfer (FRET) microscopy
      • CRISPR/Cas9-based gene editing
      • in vivo imaging of neuromodulation and subcellular signaling in awake animals
      • protein and signaling dynamics during plasticity, cAMP/protein kinase A (PKA) signaling, labeling of endogenous proteins
      • dopamine, striatum, mouse locomotion