Neuronal Signaling

Neuronal signaling encompasses much of what neurons and glia do - from membrane receptors to intracellular signaling cascades and on to gene expression in the nucleus. Studies of neuronal signaling cross subdisciplinary boundaries from cells and synapses to systems and behavior and disruptions of signaling pathways in disease. The growing interest of stem cell biology and cell-based therapies in biomedicine is as important in neuroscience as it is in other disciplines such as cancer biology. NGP faculty members interested in neuronal signaling are actively engaged in this full spectrum using approaches from biochemistry to structural biology as well as physiology and imaging. Some of the molecules under study include kinases, phosphatases, G protein coupled receptor signaling networks, cyclic nucleotides, growth factors to name a few.

To learn more about the work of NGP investigators in this area, click on the links below.

    • Appointments and titles

      • Professor of Molecular Microbiology and Immunology, School of Medicine
    • Areas of interest

      • host-pathogen interactions, neural-immune communications, neuroinflammation, infections, bacterial pathogenesis, organismal response to infections
    • Appointments and titles

      • Professor of Anesthesiology and Perioperative Medicine, School of Medicine
    • Appointments and titles

      • Assistant Professor of Medicine, Division of Cardiovascular Medicine, School of Medicine
    • Areas of interest

      • Brain Development, Radial Glia, Neuronal Polarity, Endothelial heterogeneity, Single Cell Transcriptome/Proteome Analysis
    • Appointments and titles

      • Associate Professor of Chemical Physiology and Biochemistry, School of Medicine
    • Appointments and titles

      • Professor of Cell, Developmental and Cancer Biology, School of Medicine
    • Areas of interest

      • Developmental Neuroscience
      • Mechanisms of neuronal migration
      • Neurobiology of disease
      • Simpler model systems
      • Biology of Amyloid Precursor Protein (APP)
      • Alzheimer's Disease
    • Appointments and titles

      • Professor, Vollum Institute
    • Areas of interest

      • glia
      • axon
      • Wallerian degeneration
      • neuron-glia signaling
      • astrocytes
      • neurodegeneration
      • Drosophila
    • Appointments and titles

      • Professor of Chemical Physiology and Biochemistry, School of Medicine
      • Professor of Anesthesiology and Perioperative Medicine, School of Medicine
      • Professor of Medicine, Division of Cardiovascular Medicine, School of Medicine
    • Areas of interest

      • Autonomic neuron plasticity
      • Neurotransmitter/receptor expression
    • Appointments and titles

      • Associate Professor of Neurology, School of Medicine
    • Appointments and titles

      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Dopamine receptors
      • Signal transduction
      • Cellular and molecular biology of g protein-coupled receptors
      • Structure-function analysis of dopamine receptors
      • Behavior
    • Appointments and titles

      • Professor, Vollum Institute
    • Areas of interest

      • small G proteins
      • MAP kinase
      • B-Raf
    • Appointments and titles

      • Professor of Behavioral Neuroscience, School of Medicine
    • Areas of interest

      • Synaptic plasticity underlying behavioral changes in animal models of drug addiction
    • Appointments and titles

      • Associate Professor, Vollum Institute
    • Areas of interest

      • photoactivated localization microscopy (PALM)
      • two-photon fluorescence lifetime imaging microscopy (2PFLIM)
      • fluorescence resonance energy transfer (FRET) microscopy
      • CRISPR/Cas9-based gene editing
      • in vivo imaging of neuromodulation and subcellular signaling in awake animals
      • protein and signaling dynamics during plasticity, cAMP/protein kinase A (PKA) signaling, labeling of endogenous proteins
      • dopamine, striatum, mouse locomotion