Stephen M. Smith, M.B., B.S., Ph.D.

  • Professor of Medicine, Division of Pulmonary and Critical Care Medicine, School of Medicine
  • Professor of Physiology and Pharmacology, School of Medicine
  • Director of CCM Fellowship, Medicine, Division of Pulmonary and Critical Care Medicine, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine
  • Neuroscience Graduate Program, School of Medicine


Stephen M. Smith is professor of medicine, physiology and pharmacology and CCM fellowship director at Oregon Health & Science University. In addition he is director of Medical Critical Care at VA Portland Health Care System. He obtained his medical degree and PhD at the University of Newcastle upon Tyne in England. After medical residency in London he was a registrar in intensive care at Guy’s Hospital and RPAH and RNSH in Sydney Australia. At Stanford University he worked in the laboratories of Richard Tsien and Richard Scheller in the department of Molecular and Cellular Physiology. He has been at OHSU since 2000 and VAPORHCS since 2012.


  • Ph.D., 1988, University of Newcastle upon Tyne
  • M.B.B.S., 1990, University of Newcastle upon Tyne
  • Internship:

    • Freeman Hospital, Newcastle upon Tyne and Whipp's Cross Hospital, London, 1990-91
  • Residency:

    • Medicine at the Brompton, Hammersmith, Queen’s Square, and Guy’s Hospitals.
  • Fellowship:

    • Intensive care at Guy's, Royal Prince Alfred, and Royal North Shore Hospitals 1993-97
  • Certifications:

    • MRCP (UK)
    • FRACP
    • FCICM


Selected publications

  •  Smith, S.M., Bergsman, J.B., Harata, N.C., Scheller, R.H. & Tsien, R.W. (2004). Recordings from Single Neocortical Nerve Terminals Reveal a Nonselective Cation Channel Activated by Decreases in Extracellular Calcium. Neuron, 41: 243-256.
  • Phillips, C.G., Harnett, M., Chen, W. & Smith, S.M. (2008) Extracellular Calcium-sensing receptor modulates excitatory synaptic transmission. Journal of Neuroscience. 28(46): 12062-12070.
  • Vyleta, N. & Smith, S.M. (2011) Spontaneous glutamate release is independent of calcium influx and tonically activated by the calcium-sensing receptor. Journal of Neuroscience, 31, 4593-4606. PMID: 21430159.
  • Williams, C., Chen, W., Lee, C.H., Yaeger, D., Vyleta, N., Smith, S.M. (2012) Coactivation of multiple tightly coupled calcium channels triggers spontaneous release of GABA. Nature Neuroscience, 15, 1195-1197. PMID: 22842148.
  • Tsintsadze, T., Williams, C.L., Weingarten, D., von Gersdorff, H., Smith, S.M. (2017) Distinct actions of voltage-activated Ca2+ channel block on spontaneous release at excitatory and inhibitory central synapses, Journal of Neuroscience, 37(16):4301-4310.
  • Smith, S. M., Oveson, K.E., Strauss, W., Raven, K., Lefevre, M.C., Ahmann, A.J. and Hagg, D.S. (2007) Ultradian variation of blood glucose in ICU patients receiving insulin infusions. Diabetes Care, 30:2503-2505
  • Komisarof, J.A., Gilkey, G.M., Peters, D.M., Koudelka, C.W., Meyer, M.M. & Smith, S.M. (2007) N-Acetylcysteine for Patients with Prolonged Hypotension as Prophylaxis for Acute Renal Failure (NEPHRON). Crit. Care Med. 35(2):435-441.
  • Phillips, C.R., Chesnutt, M.S. & Smith, S.M. (2008) Extravascular Lung Water in Sepsis-Associated ARDS: indexing with predicted body weight improves correlation with severity of illness and survival. Crit.Care Med. 36: 69-73.


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