Cristina Tognon, Ph.D. Medical Genetics

  • Research Associate Professor of Division of Oncological Sciences, School of Medicine
  • Scientific Director, Druker Laboratory

Biography

I am a research associate professor in the Division of Oncological Sciences, within the Knight Cancer Institute at Oregon Health & Science University (OHSU). With a Ph.D. in Medical Genetics from the University of British Columbia and over two decades of research experience, my work focuses on identifying and targeting novel therapeutic approaches for cancer treatment, specifically in the realm of functional genomics.

As the scientific director of the Druker Lab, I oversee cutting-edge projects aimed at advancing cancer therapeutics, including roles as principal and co-investigator on several NIH-funded initiatives targeting hematological malignancies and acute myeloid leukemia. In addition to my academic role, I develop and drive collaborations between academia and industry to accelerate cancer research and drug development.

I have extensive experience coordinating and leading large, multi-institutional consortium projects focused on integrating and analyzing multi-modal datasets to identify novel therapeutic targets and biomarkers of response and resistance to therapy.

With a strong foundation in both clinical and translational research, I am dedicated to discovering innovative solutions that improve patient outcomes in oncology.

Education and training

  • Degrees

    • Ph.D., 1999, University of British Columbia

Areas of interest

  • Translational Medicine
  • Functional Genomics
  • Developing and Executing Investigator Initiated Trials based on our Research

Publications

Selected publications

  • Soragni A, Knudsen ES, O'Connor TN, Tognon CE, Tyner JW, Gini B, Kim D, Bivona TG, Zang X, Witkiewicz AK, Goodrich DW, Jiang D, Gammon ST, Willey CD, Boutros PC, Sandulache VC, Osman AA, Myers JN, Mehla K, Singh PK, Chan KS, Gao H, Marathe H. Acquired resistance in cancer: towards targeted therapeutic strategies. Nat Rev Cancer. 2025 Aug;25(8):613-633. PubMed PMID: 40461793
  • Joshi SK, Huang A, Pittsenbarger J, Shinde U, Posso C, Piehowski PD, Gosline SJC, Press RD, Gritsenko MA, Hutchinson C, Weitz KK, Watanabe-Smith K, Long N, Rodland KD, Tyner JW, Druker BJ, Tognon CE. Oncogenic NTRK3 mutations exhibit differential sensitivity to tropomyosin receptor kinase inhibitors in patients with acute myeloid leukemia. Haematologica. 2025 Jul 1;110(7):1616-1622. PubMed PMID: 39945005
  • Pino JC, Posso C, Joshi SK, Nestor M, Moon J, Hansen JR, Hutchinson-Bunch C, Gritsenko MA, Weitz KK, Watanabe-Smith K, Long N, McDermott JE, Druker BJ, Liu T, Tyner JW, Agarwal A, Traer E, Piehowski PD, Tognon CE, Rodland KD, Gosline SJC. Mapping the proteogenomic landscape enables prediction of drug response in acute myeloid leukemia. Cell Rep Med. 2024 Jan 16;5(1):101359. PubMed PMID: 38232702
  • Barnes EJ, Eide CA, Kaempf A, Bottomly D, Romine KA, Wilmot B, Saunders D, McWeeney SK, Tognon CE, Druker BJ. Secondary fusion proteins as a mechanism of BCR::ABL1 kinase-independent resistance in chronic myeloid leukaemia. Br J Haematol. 2023 Feb;200(3):323-328. PubMed PMID: 36264026
  • Bottomly, D; Long N, Schultz AR, Kurtz SE, Tognon CE, et al, Integrative analysis of drug response and clinical outcome in acute myeloid leukemia. Cancer Cell. 2022 Aug 8;40(8):850-864.PubMed PMID: 35868306
  • Gosline SJC, Tognon C et al. Proteomic and phosphoproteomic measurements enhance ability to predict ex vivo drug response in AML. Clin Proteomics. 2022 Jul 27;19(1):30. doi: 10.1186/s12014-022-09367-9. PubMed PMID: 35896960
  • Joshi SK, Tognon CE, Druker BJ, Rodland KD. Oncoproteomic profiling of AML: moving beyond genomics. Expert Rev Proteomics. 2022 Jul-Dec;19(7-12):283-287.  PubMed PMID: 36734985
  • Joshi SK, Qian K, Bisson WH, Watanabe-Smith K, Huang A, Bottomly D, Traer E, Tyner JW, McWeeney SK, Davare MA, Druker BJ, Tognon CE. Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms. Blood. 2020 Jun 11;135(24):2159-2170. PubMed PMID: 32315394
  • Barnes EJ, Leonard J, Medeiros BC, Druker BJ, Tognon CE. Functional characterization of two rare BCR-FGFR1(+) leukemias. Cold Spring Harb Mol Case Stud. 2020 Apr;6(2). PubMed PMID: 31980503
  • Tyner JW, Tognon CE, et al.  Functional genomic landscape of acute myeloid leukaemia. Nature. 2018 Oct;562(7728):526-531.PubMed PMID: 30333627

Publications