Mark Pennesi M.D., Ph.D.

Photo of Mark Pennesi, M.D., Ph.D.
Faculty profile
  • Division Chief, Ophthalmic Genetics

Associate Professor of Ophthalmology School of Medicine

Accepting new patients

4.7 out of 5 (137 Ratings, 20 Comments)


  • Ophthalmology

Special focus on

  • Retinal Dystrophies Congenital/Genetic Disease


  • B.S., University of Pennsylvania, Philadelphia Pennsylvania 1997
  • Ph.D., Baylor College of Medicine, Houston Texas 2003
  • M.D., Baylor College of Medicine, Houston Texas 2004
  • Residency:

    • Transitional year, Scripps Mercy Hospital, San Diego, California, 2005
  • Fellowship:

    • Ophthalmic genetics fellowship, Casey Eye Institute, Oregon Health & Science University, 2009
  • Certifications:

    • American Board of Ophthalmology, 2010


Dr. Pennesi was born in Mount Kisco, New York, and moved to Dallas, Texas at a young age. For college, he moved to the east coast and attended the University of Pennsylvania for his undergraduate studies. There he graduated summa cum laude with a BS in biomedical engineering and was awarded the Herman P. Schwann award in bioengineering for exemplary scholarship.

Dr. Pennesi's interest in degenerative retinal disorders began shortly after his first year in college, when he spent a summer working at the Retina Foundation of the Southwest. He worked under the supervision of Dr. David Birch and saw patients with retinal degenerations such as retinitis pigmentosa as well as studying animal models of this disease.

After college, Dr. Pennesi completed a combined M.D./Ph.D. at Baylor College of Medicine in Houston, Texas. He performed his graduate Ph.D. work in the Department of Neuroscience in the lab of Dr. Samuel Wu. His thesis work focused on identifying new animal models of retinal degeneration. He received numerous awards while in graduate school, including the John J. Trentin Award for earning the highest GPA in his class and the BRASS scholarship for playing an active role in community service.

For his residency training, Dr. Pennesi spent his internship year in San Diego at Scripps Mercy Hospital, followed by his ophthalmology residency at the University of California, San Francisco. During residency he was awarded the Hogan/Garcia award for the best resident research project. After residency he completed an ophthalmic genetics fellowship under the tutelage of Dr. Richard Weleber.

Dr. Pennesi joined the faculty of Casey Eye Institute and is now an Associate Professor in Ophthalmic Genetics and as the chief of the Ophthalmic Genetics Division.

Both Research to Prevent Blindness and the Foundation Fighting Blindness have recognized Dr. Pennesi with career development awards to support his ambition to conduct transitional research that will bring treatments for diseases such as retinitis pigmentosa from the laboratory to the clinic. Additionally, he is the recipient of the 2011 ARVO/Alcon Early Clinician Scientist, the Alcon Young investigator Award in 2014, and the Casey Eye Institute Resident teach award. His research focuses on developing novel treatments for inherited retinal diseases. He is currently exploring the potential of a new class of drugs to up regulate protective growth factors in the retina.

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  • English

Patient Ratings

4.7 out of 5 (137 Ratings, 20 Comments)

The patient ratings score is an average of all responses to the question "How likely would you be to recommend this provider to your family and friends (on a scale of 0 to 10)" on our nationally-recognized NRC patient surveys.

Patient Comments

  • Dec 04, 2018

    He was professional, on time and informative

  • Nov 21, 2018


  • Nov 10, 2018

    Everything is working: good organization, good doctors, very nice people, excellent assistance.

  • Nov 05, 2018

    Living with blindness is scary for a teenager. Dr Pennesi has given me hope that if my vision was to get worse there are options to hopefully stop it or make it better.

  • Nov 03, 2018

    Our son was diagnosed with RP, Dr. pennesi has been kind enough to sit with us and answer all our questions and concerns.

  • Nov 03, 2018

    He was very through. Explained everything in detail. Easy to talk to.

  • Sep 27, 2018

    He was absolutely the best eye physian I?ve ever had. He listens to what you are saying and answers to the best of his knowledge and if he?s not sure he will let you know.

  • Sep 27, 2018

    All the questions I had were answered. He gave me encouragement and Ifelt positive about my condition when I left.

  • Sep 19, 2018

    Dr. Pennesi is always pleasant, informative and well qualified for his position.

  • Sep 15, 2018

    This was my first visit with Dr Pannessi. I thought he was very clear and helpful. He listened and was very personable..

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(503) 494-8386

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I see patients at

  • Casey Eye Institute - Marquam Hill Portland Directions