Photo of Skye C. Mayo, M.D., M.P.H., F.A.C.S.

Skye C. Mayo M.D., M.P.H., F.A.C.S.

Dr. Skye Mayo is board certified in both Complex General Surgical Oncology and in General Surgery. His clinical practice serves patients with tumors of the liver, bile ducts, and pancreas. He also treats patients with gall bladder cancer, cancers of the stomach and digestive system, and retroperitoneal sarcomas.  His research focuses on helping patients with cancers that have spread to or arise in the liver, such as colorectal cancer and intrahepatic cholangiocarcinoma.

Dr. Mayo is an Oregon native: born in Eastern Oregon and raised in Central Oregon. During his surgical residency at Johns Hopkins his clinical and research work focused on the treatment of patients with pancreatic and liver cancers.  He completed a research fellowship in Cancer Immunology at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins investigating the role of immune therapy in patients with metastatic liver disease. His surgical oncology fellowship at Memorial Sloan-Kettering Cancer Center in New York was focused in advanced Hepatopancreatobiliary Surgery where he was also certified to perform robotic cancer operations.

He is a member of a talented team of surgeons and oncologists at OHSU where he uses his experience and research to help advance the treatment of patients with cancers of the liver, bile ducts, and pancreas.  He is a member of the OHSU Knight Cancer Institute and of the Southwest Oncology Group, which offers patients the latest in cancer care through participation in clinical trials. His research at OHSU involves using hepatic arterial regional therapy for patients with liver and bile duct cancers and investigating how to harness the immune system to fight cancer. Specifically, his research efforts are directed toward the early detection of recurrent cancer and monitoring responses to treatment in patients with colorectal cancer metastatic to the liver.

Dr. Mayo views it as a privilege to work with patients, their families, and primary care doctors to develop the best treatment plans. He is dedicated to offering the highest quality of service. He looks forward to working with other cancer specialists to help give his patients the most options and the best possible outcome.

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Areas of interest

  • Early Detection of cancer recurrence
  • Liver-directed therapies for metastatic and primary liver cancers
  • Early phase clinical trial development in hepatopancreatobiliary oncology
  • Surgical management of giant retroperitoneal sarcoma
  • Risk factors for developing intrahepatic cholangiocarcinoma
  • Cancer immunology


  • M.D., Oregon Health & Science University School of Medicine 2006
  • M.P.H., Oregon Health & Science University School of Public Health and Preventive Medicine 2006
  • Internship:

    • General Surgery, The Johns Hopkins Hospital, 2006
  • Residency:

    • General Surgery, The Johns Hopkins Hospital, 2013
  • Fellowship:

    • Cancer Immunology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Medical Institutions, 2011
    • Complex General Surgical Oncology, Hepatopancreatobiliary Focus, Memorial Sloan-Kettering Cancer Center, 2013-15
  • Certifications:

    • American Board of Surgery, General Surgery, 2013
    • American Board of Surgery, Complex General Surgical Oncology, 2016

Memberships and associations

  • Society of Surgical Oncology (SSO)
  • Americas Hepato Pancreato Biliary Association (AHPBA)
  • American Society of Clinical Oncology (ASCO)
  • Connective Tissue Oncology Society (CTOS, Sarcoma)
  • American Association of Cancer Research (AACR)
  • Johns Hopkins Surgery, Old Hands Club
  • American College of Surgeons
  • North Pacific Surgical Association
  • Portland Surgical Society
  • Mackenzie Surgical Society
  • Alpha Omega Alpha (AOA) Medical Honor Society
  • SWOG (Southwest Oncology Group) Surgery and Gastrointestinal Oncology Committee Member
  • Trans Atlantic Retroperitoneal Sarcoma Working Group (TARPSWG), Member


  • "Evolving Preoperative Evaluation of Patients with Pancreatic Cancer" Journal of the American College of Surgeons January 2009
  • "Diagnostic laparoscopy for patients with potentially resectable pancreatic adenocarcinoma" Journal of Gastrointestinal Surgery July 2008
  • "Image of the month" JAMA Surgery October 2008
  • "Adjuvant therapy and survival after resection of pancreatic adenocarcinoma" Cancer June 15 2010
  • "A preclinical murine model of hepatic metastases" Journal of visualized experiments : JoVE September 27 2014
  • "Current management of colorectal hepatic metastasis" Expert Review of Gastroenterology and Hepatology  2009
  • "Treatment and prognosis of patients with fibrolamellar hepatocellular carcinoma" Journal of the American College of Surgeons February 2014
  • "Management of patients with pancreatic adenocarcinoma" Journal of the American College of Surgeons January 2012
  • "Colorectal hepatic metastasis - current therapeutic approach" European Gastroenterology and Hepatology Review  2011
  • "Shifting trends in liver-directed management of patients with colorectal liver metastasis" Surgery (United States) August 2011
  • "Conditional survival in patients with pancreatic ductal adenocarcinoma resected with curative intent" Cancer May 15 2012
  • "Surgical management of patients with synchronous colorectal liver metastasis" Journal of the American College of Surgeons April 2013
  • "Neuroendocrine liver metastasis" JAMA Surgery January 2012
  • "The top 10 list for a safe and effective sign-out" JAMA Surgery October 2008
  • "Surgical management of neuroendocrine tumors" ONCOLOGY (United States)  2011
  • "miRNA biomarkers in cyst fluid augment the diagnosis and management of pancreatic cysts" Clinical Cancer Research September 1 2012
  • "Surgery versus intra-arterial therapy for neuroendocrine liver metastasis" Annals of Surgical Oncology December 2011
  • "Loss of expression of the SWI/SNF chromatin remodeling subunit BRG1/SMARCA4 is frequently observed in intraductal papillary mucinous neoplasms of the pancreas" Human Pathology April 2012
  • "National trends in surgical procedures for hepatocellular carcinoma" Cancer April 1 2012
  • "Thermal ablative therapies for secondary hepatic malignancies" Cancer journal (Sudbury, Mass.) March 2010
  • "Post-treatment surveillance of patients with colorectal cancer with surgically treated liver metastases" Surgery (United States) August 2013
  • "Emerging approaches in the management of patients with neuroendocrine liver metastasis" Journal of the American College of Surgeons January 2013
  • "Refining the definition of perioperative mortality following hepatectomy using death within 90 days as the standard criterion" HPB July 2011
  • "Surgical management of hepatic neuroendocrine tumor metastasis" Annals of Surgical Oncology December 2010
  • "Repeat curative intent liver surgery is safe and effective for recurrent colorectal liver metastasis" Journal of Gastrointestinal Surgery December 2009
  • "National Trends in the Management and Survival of Surgically Managed Gallbladder Adenocarcinoma Over 15 years" Journal of Gastrointestinal Surgery  2010
  • "Presence of pancreatic intraepithelial neoplasia in the pancreatic transection margin does not influence outcome in patients with R0 resected pancreatic cancer" Annals of Surgical Oncology November 2011
  • "A systematic review" Journal of the American College of Surgeons December 2012
  • "Surgical management and emerging therapies to prolong survival in metastatic neuroendocrine cancer" Annals of Surgical Oncology December 2011
  • "Surgical therapy for early hepatocellular carcinoma in the modern era" Annals of Surgery December 2013

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