Photo of Paul T. Spellman, Ph.D.

Paul T. Spellman Ph.D.

    • Professor of Molecular and Medical Genetics School of Medicine
    • Co-Director, CEDAR OHSU Knight Cancer Institute School of Medicine
    • Molecular and Medical Genetics Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Paul Spellman, Ph.D., is a professor in the Department of Molecular and Medical Genetics in the OHSU School of Medicine and co-leader of the Quantitative Oncology Program in the OHSU Knight Cancer Institute. He uses genetic and genomic approaches to understand the processes by which cancer develops, monitor disease, and to identify therapeutic strategies. He focuses on using population genetics to help determine who is at risk for cancer, how to computationally analyze genomic data to identify early changes in cancers, and how to accurately screen different populations for the disease. He also works to inform the public about the ways that genetics shape cancer risk. Spellman received his Ph.D. in genetics from Stanford University.

Areas of interest

  • Genetics
  • Geonomics

Memberships and associations

  • OHSU Center for Spatial Systems Biomedicine

Publications

  • "Molecular Cytogenetics Guides Massively Parallel Sequencing of a Radiation-Induced Chromosome Translocation in Human Cells." Radiation Research In: , Vol. 190, No. 1, 01.07.2018, p. 88-97.
  • "Erratum : The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma (Cell Reports (2018) 23(1) (313–326.e5) (S2211124718304364) (10.1016/j.celrep.2018.03.075))." Cell Reports  In: , Vol. 23, No. 12, 19.06.2018.
  • "The Immune Landscape of Cancer." Immunity  In: , Vol. 48, No. 4, 17.04.2018, p. 812-830.e14.
  • "lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer." Cancer Cell  In: , Vol. 33, No. 4, 09.04.2018, p. 706-720.e9.
  • "Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas." Cancer Cell  In: , Vol. 33, No. 4, 09.04.2018, p. 721-735.e8.
  • "A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers." Cancer Cell  In: , Vol. 33, No. 4, 09.04.2018, p. 690-705.e9.
  • "Genomic and Functional Approaches to Understanding Cancer Aneuploidy." Cancer Cell  In: , Vol. 33, No. 4, 09.04.2018, p. 676-689.e3.
  • "Oncogenic Signaling Pathways in The Cancer Genome Atlas." Cell  In: , Vol. 173, No. 2, 05.04.2018, p. 321-337.e10.
  • "Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation." Cell  In: , Vol. 173, No. 2, 05.04.2018, p. 338-354.e15.
  • "Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer." Cell  In: , Vol. 173, No. 2, 05.04.2018, p. 291-304.e6.
  • "An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics." Cell  In: , Vol. 173, No. 2, 05.04.2018, p. 400-416.e11.
  • "Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics." Cell  In: , Vol. 173, No. 2, 05.04.2018, p. 305-320.e10.
  • "A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples." Cell  In: , Vol. 173, No. 2, 05.04.2018, p. 386-399.e12.
  • "Comprehensive Characterization of Cancer Driver Genes and Mutations." Cell  In: , Vol. 173, No. 2, 05.04.2018, p. 371-385.e18.
  • "Pathogenic Germline Variants in 10,389 Adult Cancers." Cell  In: , Vol. 173, No. 2, 05.04.2018, p. 355-370.e14.
  • "Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types." Cell Reports  In: , Vol. 23, No. 1, 03.04.2018, p. 213-226.e3.
  • "Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context." Cell Reports  In: , Vol. 23, No. 1, 03.04.2018, p. 297-312.e12.
  • "Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas." Cell Reports  In: , Vol. 23, No. 1, 03.04.2018, p. 194-212.e6.
  • "Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas." Cell Reports  In: , Vol. 23, No. 1, 03.04.2018, p. 172-180.e3.
  • "The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma." Cell Reports  In: , Vol. 23, No. 1, 03.04.2018, p. 313-326.e5.
  • "Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers." Cell Reports  In: , Vol. 23, No. 1, 03.04.2018, p. 255-269.e4.
  • "Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images." Cell Reports  In: , Vol. 23, No. 1, 03.04.2018, p. 181-193.e7.
  • "Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types." Cell Reports  In: , Vol. 23, No. 1, 03.04.2018, p. 282-296.e4.
  • "Driver Fusions and Their Implications in the Development and Treatment of Human Cancers." Cell Reports  In: , Vol. 23, No. 1, 03.04.2018, p. 227-238.e3.
  • "Systematic Analysis of Splice-Site-Creating Mutations in Cancer." Cell Reports  In: , Vol. 23, No. 1, 03.04.2018, p. 270-281.e3.
  • "Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas." Cell Reports  In: , Vol. 23, No. 1, 03.04.2018, p. 239-254.e6.
  • "MHC class I loaded ligands from breast cancer cell lines : A potential HLA-I-typed antigen collection." Journal of Proteomics In: , Vol. 176, 30.03.2018, p. 13-23.
  • "Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas." Cell Systems  In: , Vol. 6, No. 3, 28.03.2018, p. 282-300.e2.
  • "Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines." Cell Systems  In: , Vol. 6, No. 3, 28.03.2018, p. 271-281.e7.
  • "The Integrated Genomic Landscape of Thymic Epithelial Tumors." Cancer Cell  In: , Vol. 33, No. 2, 12.02.2018, p. 244-258.e10.

Additional information

Edit profile