Photo of Jonah B. Sacha, Ph.D.

Jonah B. Sacha Ph.D.

  • (503) 418-2774
    • Associate Professor VGTI-Vaccine and Gene Therapy Institute
    • Molecular Microbiology and Immunology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Sacha graduated cum laude from the University of Missouri-Columbia in 2003 with a B.A. in German and B.S. in Biology.  After receiving his Ph.D. in Medical Microbiology & Immunology from the University of Wisconsin-Madison in 2007, he joined the faculty at UW-Madison where he researched the characteristics of effective retrovirus-specific CD8+ and CD4+ T cells.  In 2011, he joined the Oregon Health & Science University and has appointments in both the Vaccine & Gene Therapy Institute and Oregon National Primate Research Center.

Areas of interest

  • T cell Biology
  • Retroviruses
  • Vaccine development

Education

  • B.S., University of Missouri, Columbia Missouri United States 2003
  • Ph.D., University of Wisconsin, Madison Wisconsin United States 2007

Honors and awards

  • 2013 - Creative and Novel Ideas in HIV Research Award
  • 2011 - AIDS Vaccine Conference Scholarship Award
  • 2011 - Young Investigator Editor for AIDS Research & Human Retroviruses
  • 2008 - Nonhuman Primate Symposium Young Investigator Scholarship
  • 2008 - University of Wisconsin-Madison Vilas Travel Scholarship
  • 2007 - Keystone Symposia: HIV Vaccines Young Investigator Scholarship
  • 2003 - National Science Foundation REU Graduate Fellowship
  • 2003 - Bachelor of Science with Departmental Honors
  • 2003 - Bachelor of Science with Honors, cum laude
  • 2003 - Bachelor of Arts with Honors, cum laude
  • 1997 - Rotary International Youth Ambassador to Germany
  • 1997 - Bright Flight Undergraduate Scholarship (maintained all years at University of Missouri)

Memberships and associations

  • Member, American Society of Microbiology
  • Member, Society for Leukocyte Biology
  • Member, International AIDS Society
  • Member, American Society of Hematology

Publications

  • "Pyrosequencing reveals restricted patterns of CD8 + T cell escape-associated compensatory mutations in simian immunodeficiency virus" Journal of Virology December 2011
  • "Cytomegalovirus vectors violate CD8+ T cell epitope recognition paradigms" Science  2013
  • "Technical advance" Journal of Leukocyte Biology  2014
  • "Erratum" Nature October 30 2014
  • "Tertiary mutations stabilize CD8+ T lymphocyte escape-associated compensatory mutations following transmission of simian immunodeficiency virus" Journal of Virology  2014
  • "Vaccination against endogenous retrotransposable element consensus sequences does not protect rhesus macaques from SIVsmE660 infection and replication" PLoS One March 20 2014
  • "Immune clearance of highly pathogenic SIV infection" Nature  2013
  • "Gag-specific CD8+ T lymphocytes recognize infected cells before AIDS-virus integration and viral protein expression" Journal of Immunology March 1 2007
  • "T cells target APOBEC3 proteins in human immunodeficiency virus type 1-infected humans and simian immunodeficiency virus-infected indian rhesus macaques" Journal of Virology June 2013
  • "Expansion of dysfunctional Tim-3 - Expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques" Journal of Immunology December 1 2014
  • "T Cell Inactivation by Poxviral B22 Family Proteins Increases Viral Virulence" PLoS Pathogens  2014
  • "Neutralizing polyclonal IgG present during acute infection prevents rapid disease onset in simian-human immunodeficiency virus SHIVSF162P3-infected infant rhesus macaques" Journal of Virology  2013
  • "CD8+ and CD4+ cytotoxic T cell escape mutations precede breakthrough SIVmac239 viremia in an elite controller" Retrovirology November 6 2012
  • "The trim5α genotype of rhesus macaques affects acquisition of simian immunodeficiency virus SIVsmE660 infection after repeated limiting-dose intrarectal challenge" Journal of Virology September 2011
  • "Simian immunodeficiency virus-specific CD8+ T cells recognize Vpr- and Rev-derived epitopes early after infection" Journal of Virology October 2010
  • "Differential antigen presentation kinetics of CD8+ T-cell epitopes derived from the same viral protein" Journal of Virology September 2008
  • "Recombinant yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 gag induces SIV-specific CD8+ T-cell responses in rhesus macaques" Journal of Virology April 2010
  • "Novel translation products from simian immunodeficiency virus SIVmac239 Env-encoding mRNA contain both Rev and cryptic T-cell epitopes" Journal of Virology October 2009
  • "Early antigen presentation of protective HIV-1 KF11Gag and KK10Gag epitopes from incoming viral particles facilitates rapid recognition of infected cells by specific CD8+ T Cells" Journal of Virology March 2013
  • "Synchronous infection of SIV and HIV in vitro for virology, immunology and vaccine-related studies" Nature Protocols February 2010
  • "Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control" Immunity December 19 2008
  • "HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates" Journal of Clinical Investigation December 3 2012
  • "Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic" Journal of Virology January 2010
  • "Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic" Journal of Immunology August 1 2012
  • "Pol-specific CD8+ T cells recognize simian immunodeficiency virus-infected cells prior to Nef-mediated major histocompatibility complex class I downregulation" Journal of Virology November 2007
  • "Two-year follow-up of macaques developing intermittent control of the human immunodeficiency virus homolog simian immunodeficiency virus SIVmac251 in the chronic phase of infection" Journal of Virology  2015
  • "Robust, vaccine-induced CD8+ T lymphocyte response against an out-of-frame epitope" Journal of Immunology January 1 2010
  • "Efficacious early antiviral activity of HIV Gag- and Pol-specific HLA-B*2705-restricted CD8+ T cells" Journal of Virology October 2010
  • "Trans-activation, post-transcriptional maturation, and induction of antibodies to HERV-K (HML-2) envelope transmembrane protein in HIV-1 infection" Retrovirology January 28 2014
  • "The majority of freshly sorted Simian Immunodeficiency Virus (SIV)-specific CD8+ T cells cannot suppress viral replication in SIV-infected macrophages" Journal of Virology April 2012

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