Brian J. Druker, M.D.

  • Professor of Medicine, Division of Hematology/Medical Oncology, School of Medicine
  • Associate Dean, Oncology, Office of the Dean, School of Medicine
  • Director, OHSU Knight Cancer Institute, School of Medicine
  • JELD-WEN Chair of Leukemia Research
  • Cancer Biology Graduate Program, School of Medicine
  • Program in Molecular and Cellular Biosciences, School of Medicine

Biography

Dr. Druker's research focuses on activated tyrosine kinases with an emphasis on signal transduction and cellular transformation and the application of this knowledge to cancer therapies. The BCR-ABL oncogene is his lab's primary model system because of its central role in the pathogenesis of a human disease, chronic myeloid leukemia (CML). Numerous tyrosine phosphorylated proteins have been identified in BCR-ABL transformed cells and projects are ongoing to define their necessity for BCR-ABL function. These studies include mutational, biochemical and genetic approaches. Imatinib (Gleevec), a specific inhibitor of the ABL protein tyrosine kinase, has been proven to be an effective therapeutic agent in CML. However, it is not capable of eliminating all leukemic cells. In laboratory correlate studies done alongside imatinib clinical trials, Dr. Druker's lab learned that ABL kinase domain mutations are the most common mechanism of resistance to imatinib. Using this information, his team has evaluated several novel ABL inhibitors that are now available to treat patients with Gleevec resistance. Lastly, Dr. Druker's lab is performing screens for other tyrosine kinases that may be pathogenic in other leukemias and has developed functional assays that allow rapid target identification.

Education

  • M.D., 1981, University of California San Diego
  • Residency:

    • Barnes Hospital, Washington University, St. Louis
  • Fellowship:

    • Medical oncology - Dana-Farber Cancer Institute, Harvard Medical School, Boston
  • Certifications:

    • American Board of Internal Medicine, 1984

Memberships and associations

  • Institute of Medicine: National Academy of Sciences
  • American Association of Physicians
  • National Academy of Sciences
  • American Society for Clinical Investigation
  • American Society of Hematology
  • American Society of Clinical Oncology
  • American Association for Cancer Research
  • American Association for the Advancement of Science
  • American Society for Microbiology
  • Children’s Oncology Group
  • The American Society for Cell Biology

Publications

Publications

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