Photo of Bonnie Nagel, Ph.D.

Bonnie Nagel Ph.D.

  • (503) 494-8617
    • Professor of Psychiatry, Division of Clinical Psychology School of Medicine
    • Vice Chair for Research Psychiatry School of Medicine
    • Behavioral Neuroscience Graduate Program School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • M.D./Ph.D. Program Committee School of Medicine

Dr. Nagel is an Professor of Psychiatry and Behavioral Neuroscience at Oregon Health & Science University, where she serves as the Vice Chair for Research in the Department of Psychiatry, directs the Developmental Brain Imaging Laboratory, and is the Director of pediatric neuropsychology and a practicing neuropsychologist within the Division of Child and Adolescent Psychiatry. Dr. Nagel's research focuses on adolescent brain and cognitive development in healthy and at-risk populations. Her work has primarily focused on understanding the development of executive, emotional, and reward-based networks in the brain using neuroimaging and how perturbations to these systems may result in a heightened vulnerability for mental illness during the adolescent years. More specifically, her lab has been conducting longitudinal neuroimaging studies of Portland-area youth for the past 10 years, with aims toward identifying neurobiological markers of risk and resilience for psychopathology, including addiction, and hopes of ultimately informing more targeted intervention and prevention efforts. She is a Principal Investigator on several federally-funded National multi-site projects toward that end, including the National Consortium on Alcohol & Neurodevelopment in Adolescence (NCANDA) and the recently funded Adolescent Brain Cognitive Development Study (ABCD).

Dr. Nagel has extensive experience in the neuropsychological evaluation of children and adolescents referred for a variety of conditions, including epilepsy, learning disabilities, traumatic brain injury, genetic/metabolic abnormalities, brain tumors, and attention problems. Dr. Nagel's primary research focuses on exploring typical adolescent brain and cognitive development using structural and functional neuroimaging and neuropsychological assessment techniques. Additionally, Dr. Nagel has applied her research findings and methodologies from her studies of normally developing youth to other populations, including pediatric cancer survivors and adolescents with substance abuse disorders. Dr. Nagel has published several peer-reviewed articles in the area of child and adolescent cognition and brain development, serves as an ad-hoc reviewer for several scholarly journals, and regularly attends and presents at professional conferences. Dr. Nagel has also been involved with teaching and supervision of undergraduate, graduate, and medical students.

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Education

  • B.S., Washington State University, Pullman Washington United States 1995
  • Ph.D., University of Memphis, Memphis Tennessee United States 2003
  • Fellowship:

    • NIMH post-doctoral fellow, biological psychiatry and neuroscience, UCSD, 2003-05

Publications

  • "High and low sensation seeking adolescents show distinct patterns of brain activity during reward processing" NeuroImage February 1 2013
  • "Differential cross-sectional and longitudinal impact of APOE genotype on hippocampal volumes in nondemented older adults" Dementia and Geriatric Cognitive Disorders May 2007
  • "Abstinent adolescent marijuana users show altered fMRI response during spatial working memory" Psychiatry Research - Neuroimaging May 30 2008
  • "Reduced hippocampal volume among adolescents with alcohol use disorders without psychiatric comorbidity" Psychiatry Research - Neuroimaging August 30 2005
  • "Developmental sex differences in resting state functional connectivity of amygdala sub-regions" NeuroImage July 5 2015
  • "Hippocampal volumes in adolescents with and without a family history of alcoholism" American Journal of Drug and Alcohol Abuse May 2010
  • "Brain connectivity and applications to neuropsychology" Neuropsychology Review March 2014
  • "Gender and adolescent alcohol use disorders on BOLD (blood oxygen level dependent) response to spatial working memory" British Journal on Alcohol and Alcoholism May 2005
  • "White matter connectivity and aerobic fitness in male adolescents" Developmental Cognitive Neuroscience January 2014
  • "Age-related changes in prefrontal white matter volume across adolescence" NeuroReport September 2006
  • "Reduced cerebellar brain activity during reward processing in adolescent binge drinkers" Developmental Cognitive Neuroscience December 19 2014
  • "Prefrontal cortex morphometry in abstinent adolescent marijuana users" Addiction Biology October 2009
  • "White matter microstructure correlates of inhibition and task-switching in adolescents" Brain Research August 21 2013
  • "Verbal paired-associate learning by APOE genotype in non-demented older adults" Neurobiology of Aging February 2007
  • "A preliminary study of functional magnetic resonance imaging response during verbal encoding among adolescent binge drinkers" Alcohol January 2010
  • "Toward discovery science of human brain function" Proceedings of the National Academy of Sciences of the United States of America March 9 2010
  • "The attenuation of dysfunctional emotional processing with stimulant medication" Psychiatry Research - Neuroimaging September 30 2011
  • "Prefrontal cortex volumes in adolescents with alcohol use disorders" Alcoholism: Clinical and Experimental Research March 2008
  • "Abnormal hippocampal development in children with medulloblastoma treated with risk-adapted irradiation" American Journal of Neuroradiology October 2004
  • "Risky Decision-Making" Alcoholism: Clinical and Experimental Research April 2012
  • "Atypical default network connectivity in youth with attention-deficit/ hyperactivity disorder" Biological Psychiatry December 15 2010
  • "fMRI reveals alteration of spatial working memory networks across adolescence" Journal of the International Neuropsychological Society September 2005
  • "Advances in human neuroconnectivity research" Alcohol research : current reviews  2015
  • "Atypical parietal lobe activity to subliminal faces in youth with a family history of alcoholism" American Journal of Drug and Alcohol Abuse March 1 2015
  • "Neurobiological Phenotypes of Familial Chronic Pain in Adolescence" Journal of Pain September 1 2015
  • "Resting state functional connectivity of the nucleus accumbens in youth with a family history of alcoholism" Psychiatry Research - Neuroimaging March 30 2014
  • "Microstructural integrity of the corpus callosum linked with neuropsychological performance in adolescents" Brain and Cognition July 2008
  • "The use of magnetic resonance spectroscopy and magnetic resonance imaging in alcohol research" Alcohol research : current reviews  2008
  • "Tyrosine supplements for ADHD symptoms with comorbid phenylketonuria" Journal of Neuropsychiatry and Clinical Neurosciences March 2009
  • "The effects of age, sex, and hormones on emotional conflict-related brain response during adolescence" Brain and Cognition October 1 2015

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