Currently Enrolling Studies

 Ensayos Clínicos Disponibles en Español:

Tenemos personal que hablan Español. Para obtener más información o saber si usted califica para participar, llame a la línea confidencial de reclutamiento de la Unidad de Investigación Sobre la Salud Femenina al 503-494-3666 o escríbanos a whru@ohsu.edu.

Estudios disponibles en Español:

Contraception and birth control

LevoCept® Hormonal IUD Study

This study is currently closed to enrollment.

The purpose of this study is to investigate a new form of hormonal contraception called LevoCept® as a possible long-acting and reversible hormonal IUD. PI: Jeffrey Jensen MD, MPH eIRB# 21929

Emergency Contraceptive Disparities Study

This study is being conducted to learn more about why some people are at greater risk for oral emergency contraceptive failure while others are not. We are hoping to find out if genetic differences impact the risk of emergency contraception failure. PI: Alison Edelman, MD, MPH; IRB# 24952 

Insights in Endocervical Mucus Secretion

This study aims to evaluate the changes in cervical mucus with hormone differences. We hope to use this information to help us develop new non-hormonal birth control Principal Investigator: Leo Han, M.D. eIRB: #28821

Pregnancy and infertility

Continuous glucose monitoring for management of type 2 diabetes in pregnancy

The purpose of this study is to provide pregnant people with type 2 diabetes an opportunity to participate in a project that will help us understand if using CGM in pregnancy can improve sugars and lower pregnancy complications compared to our current standard blood sugar monitoring using fingersticks. PI: Amy Valent, DO, IRB#: 27883

Assessing the use of wearable activity trackers in a pregnancy cohort

The purpose of this study is to determine the feasibility of assessing physical activity in pregnant patients using wearable activity trackers. We will also collect pilot data on the behavioral impact of wearable activity trackers on physical activity in pregnancy after counseling. PIs: Danielle Prentice, DO and Sherilyn DeStefano, MD, eIRB#: 28457

Clinical Utility of a Predictive Model of Placental Insufficiency

The goal of this study is to better determine which pregnancies are at increased risk of complications like stillbirth, growth restriction, and preeclampsia. We will test a combination of lab tests, ultrasound studies, and risk factors to determine risk. The long-term goal is to use this improved risk assessment to improve monitoring of high risk pregnancies and prevent preventable stillbirths. PI: Karen J. Gibbins, MD, MSCI, eIRB#: 26808

IVIDA2

The purpose of this is to determine the efficacy and safety of treating pregnant patients who have a diagnosis of iron deficiency anemia with an iron infusion compared to oral iron supplements and evaluating the effectiveness of both. Both study treatments are currently used in obstetric practice but have not been adequately compared in pregnancy.  PI: Ashley Benson, M.D., M.A., M.S., IRB#: 27128

Pregnancy Data Repository to Assess Management of Type 1 Diabetes with Diabetes Technology (PRAM-T1D)

Purpose of the Study: Help us understand how pregnant people with T1D use health tech to take care of their diabetes. Examples of health tech are glucose sensors (CGM; continuous glucose monitoring) and
insulin pumps. Our goal is to make managing T1D in pregnancy easier. By sharing your T1D pregnancy data, you could help make diabetes health tech work better in the future for people with T1D who become pregnant. PI: Amy Valent, DO 

Using Inhaled insulin among pregnant people with GDM. (INHALE-GDM)

This study is being done to find out how well inhaling insulin can lower your blood sugar after a meal compared to the standard insulin injection given with your meal. We believe inhaling insulin may work better but we do not know this yet so this study will help us find out. 30 pregnant people from 5 sites around the U.S. will be in the study. PI: Amy Valent, DO; IRB#: 28056

Exercise and Pregnancy Study

This is a study designed to measure the effects of the timing of low-resistance or cardio exercise on blood sugars after eating a meal. We are inviting pregnant women at less than 30 weeks who have been diagnosed with gestational diabetes and are managing their diabetes with nutrition and lifestyle behaviors. PI: Amy Valent, DO; IRB: 20116

Placenta repository: A study of placental function in healthy and pathological pregnancies

Our long term goal is to identify pregnancies that are at risk of poor outcomes and to develop methods for prevention and treatment. PI: Leonardo Pereira, MD; IRB# 16328

Reproductive health clinics experiences survey

If you have experienced or witnessed misleading and deceptive conduct by Crisis Pregnancy Centers, take a survey to report your experience. This survey is open to the public, pregnant people and health care workers. Principal Investigator: Abigail Liberty, M.D. IRB# 26448

Menopause

Vulvar care

Remote Mindfulness-Education for Women with Provoked Localized Vulvodynia

This is a study designed to learn more about the use of an online remote education and mindfulness practice program for pain and anxiety associated with provoked localized vulvodynia. Participants will be randomized to one of two groups: online education seminars alone or mindfulness practice using the Headspace app in combination with the online education seminars. PI: Amie Leaverton, M.D. IRB# 18191

Vestibulectomy Comparison Study

The purpose of this research study is to compare two vestibulectomy surgical techniques, modified and traditional, for the treatment of provoked localized vulvodynia (PVD). This study may help us learn about the best options for treating PVD.  PI: Catherine Leclair, MD IRB# 24107

Other areas of women's health

Endometrial Responses to GLP-1 Agonist Use and Bariatric Surgery

The purpose of this study is to understand the impact of GLP-1 agonist medication (used for weight loss, e.g., Wegovy, Zepbound) and bariatric surgery (weight loss surgery, e.g., gastric bypass) on the menstrual cycle. Principal Investigator: Leo Han, MD, MPH., eIRB#: 28546

Endometrial Biopsy Study

The purpose of this research is to study the endometrium (the tissue lining the uterus) in order to learn more about possible medical treatments for endometriosis, a painful condition in women in which the endometrium develops abnormally on the pelvic organs. PI: Jeff Jensen, MD MPH; IRB#: 5108

Cell Culture & Cervical Mucus

The purpose of this study is to help us determine how hormones impact the production of cervical mucus. PI: Leo Han, MD, MPH; IRB: 18776

Women's and gynecologic cancers

In partnership with the Knight Cancer Institute

Find current trials involving ovarian, uterine and cervical cancers

Barriers and facilitators to cervical cancer screening among American Indian/Alaska Native (AI/AN) individuals aged 50-64 years

The goal of this study is to learn what factors promote or prevent participation in cervical cancer screening among AI/AN individuals age 50 to 64. This will be achieved through survey research and focus group discussions. PI:Amanda Bruegl, MD, MCR, IRB#: 25082

Heavy menstrual bleeding studies

Heavy Menstrual Bleeding in Renal Disease Study

This study is investigating the experience of period bleeding for people with kidney disease. Very little is known about the effects of kidney disease on gynecologic health, including periods, and we want to get a better understanding of the heaviness of vaginal bleeding and its impact on daily life. PI : Julia Tasset, MD, MPH IRB #27656