Currently Enrolling Studies Contraception and birth control Do you need emergency contraception? The purpose of this study is to assess how effective different doses of emergency contraception work at preventing pregnancy for women who weigh more an 176 lbs. PI: Alison Edelman, MD, MPH; IRB# 18441 Emergency contraception and BMI The purpose of this study is to improve effectiveness of orally-dosed emergency contraceptives for women of higher BMIs. PI: Alison Edelman, MD, MPH; IRB# 16291 Liletta® IUD and heavy menstrual bleeding The purpose of this study is to investigate the effectiveness of a hormonal IUD at treating very heavy menstrual bleeding. PI: Jeffrey Jensen, MD, MPH; IRB# 19016 PEARL study Pharmacist Expanded Access to Reproductive Healthcare. PI: Maria Rodriguez, MD, MPH; IRB #16158 Vaginal contraceptive ring The purpose of this study is to investigate how effective a new vaginal contraceptive ring is at preventing pregnancy. PI: Jeffrey Jensen, MD, MPH; IRB# 18041 Pregnancy and infertility Continuous Core Body Temperature and the Onset of Parturition in Women Dr. Elise Erickson, Ph.D., CNM is studying how body temperature changes before labor starts line up with when labor begins using an FDA approved device. You will be asked to wear a small flat device on your skin that measures body temperature continuously and answer a few questions each day about your activities until labor starts. PI: Dr. Elise Erickson, Ph.D., CNM; IRB#20059 Target High-Throughput Methylome Analysis of Early and Late Onset Preeclampsia The purpose of this study is to examine the genetic differences in early preeclampsia and late preeclampsia pregnancies of mothers and their babies and how those differences compare to women who do not have preeclampsia. PI: Kent Thornburg, PhD, IRB #19294 Chronic hypertension and pregnancy This study is being done to evaluate what the best and safest treatment for mild chronic hypertension during pregnancy is for both mother and baby. PI: Leonardo Pereira, MD, MCR; IRB# 17011 Maternal well-being study We are interested in working with pregnant women to reduce mood symptoms and promote well-being during pregnancy and postpartum. PI: Kristen Mackiewicz Seghete, PhD; IRB# 19004 Medical optimization and management of pregnancies with overt type 2 diabetes (MOMPOD) The purpose of this study is to learn about the safety and effectiveness of the study drug metformin when added to insulin treatment to help treat type 2 and early diagnosed diabetes in pregnancy. The study is trying to find out if metformin can be used safely in pregnancy to improve diabetes care and reduce problems at birth. PI: Amy Valent, DO; IRB #18438 Oxytocin receptor DNA methylation and postpartum maternal outcomes In this study we are tying to learn if genetics plays a role in why some women have too much bleeding after birth. We are also interested in knowing more about how women's physical and mental recovery goes in the first year after birth whether or not they have had too much bleeding and how it related to their genetics as well. PI: Elise Erickson, PhD, CNM; IRB# 18841 Placenta repository: A study of placental function in healthy and pathological pregnancies Our long term goal is to identify pregnancies that are at risk of poor outcomes and to develop methods for prevention and treatment. PI: Leonardo Pereira, MD; IRB# 16328 Prenatal environment and child Health (PEACH) study OHSU researchers are conducting a study that looks at how maternal diet and metabolic state during pregnancy might affect child brain development and behavior. You can help us by participating in our research. PI: Elinor Sullivan, PhD and Joel Nigg, PhD; IRB #18579 Roo study on mom and baby well-being We are looking for pregnant people who have experienced difficulties with low mood, anxiety or high stress levels. We hope to learn if mindfulness groups can promote well-being and self-care during pregnancy and support infant brain development. PI: Alice Graham, PhD; IRB #19166 Rosacea course fluctuations during pregnancy: A longitudinal observational study The purpose of this study is to characterize the course of rosacea severity throughout pregnancy. PI: Jon Hanifin, MD; IRB# 16647 VentFirst: A multicenter RCT of assisted ventilation during delayed cord clamping for micro-preemies The purpose of this study is to determine whether delaying clamping of the umbilical cord up to 120 seconds and assisting breathing for extremely premature babies during that time reduces intraventricular hemorrhage (bleeding in the brain). PI: Jamie B. Warren, MD, MPH; IRB#15777 Menopause Overactive bladder study The purpose of this research study is to determine if the urinary microbiome affects overactive bladder syndrome (OAB). Currently, not much is known about the cause of OAB. This study seeks to determine if bacteria in the urinary tract play a role in OAB. PI: Lisa Karstens, PhD and Rahel Nardos, MD; IRB # 10729 Remote mindfulness-education for women with provoked localized vulvodynia This is a study designed to learn more about the use of an online remote education and mindfulness practice program for the pain and anxiety associated with provoked localized vulvodynia. Participants will be randomized to one of two groups: online education seminars alone or mindfulness practice using the Headspace app in combination with the online education seminars. PI: Catherine Leclair, MD; IRB #18191 Incontinence and urogynecology Overactive bladder study The purpose of this research study is to determine if the urinary microbiome affects overactive bladder syndrome (OAB). Currently, not much is known about the cause of OAB; this study seeks to determine if bacteria in the urinary tract play a role in OAB. PI: Lisa Karstens, PhD and Rahel Nardos, MD; IRB # 10729 Heavy menstrual bleeding Liletta® IUD and heavy menstrual bleeding study The purpose of this study is to investigate the effectiveness of a hormonal IUD at treating very heavy menstrual bleeding. PI: Jeffrey Jensen, MD, MPH; IRB# 19016 Management of Pain from Endometriosis in Pre-Menopausal Women The Women’s Health Research Unit is conducting a study to evaluate the safety and effectiveness of a new investigational medication, Linzagolix, for pain in women with endometriosis. PI: Jeffrey Jensen, MD, MPH; IRB# 19890. Other areas of women's health OHSU employees' opinions of clinical research The goal of this study is to identify how employees feel regarding their participation in clinical research. PI: Jeffrey Jensen, MD, MPH; IRB #: 17248 Remote mindfulness-education for women with provoked localized vulvodynia This is a study designed to learn more about the use of an online remote education and mindfulness practice program for the pain and anxiety associated with provoked localized vulvodynia. Participants will be randomized to one of two groups: online education seminars alone or mindfulness practice using the Headspace app in combination with the online education seminars. PI: Catherine Leclair, MD; IRB #18191 Web search and women's health study The purpose of this study is to learn more about how women use the internet to search for information relating to topics of women’s health such as abortion and C-section. This study also wants to learn what types of internet sources women use most frequently and what sources they find most trustworthy. PI: Leo Han, MD, MPH; IRB# 19117 TelAbortion study The purpose of this study is to assess service provision of medical abortion through telemedicine. IRB# 15974 Management of Pain from Endometriosis in Pre-Menopausal Women The Women’s Health Research Unit is conducting a study to evaluate the safety and effectiveness of a new investigational medication, Linzagolix, for pain in women with endometriosis. PI: Jeffrey Jensen, MD, MPH; IRB# 19890. Women's and gynecologic cancers In partnership with the Knight Cancer Institute Find current trials involving ovarian, uterine and cervical cancers
Currently Enrolling Studies Contraception and birth control Do you need emergency contraception? The purpose of this study is to assess how effective different doses of emergency contraception work at preventing pregnancy for women who weigh more an 176 lbs. PI: Alison Edelman, MD, MPH; IRB# 18441 Emergency contraception and BMI The purpose of this study is to improve effectiveness of orally-dosed emergency contraceptives for women of higher BMIs. PI: Alison Edelman, MD, MPH; IRB# 16291 Liletta® IUD and heavy menstrual bleeding The purpose of this study is to investigate the effectiveness of a hormonal IUD at treating very heavy menstrual bleeding. PI: Jeffrey Jensen, MD, MPH; IRB# 19016 PEARL study Pharmacist Expanded Access to Reproductive Healthcare. PI: Maria Rodriguez, MD, MPH; IRB #16158 Vaginal contraceptive ring The purpose of this study is to investigate how effective a new vaginal contraceptive ring is at preventing pregnancy. PI: Jeffrey Jensen, MD, MPH; IRB# 18041 Pregnancy and infertility Continuous Core Body Temperature and the Onset of Parturition in Women Dr. Elise Erickson, Ph.D., CNM is studying how body temperature changes before labor starts line up with when labor begins using an FDA approved device. You will be asked to wear a small flat device on your skin that measures body temperature continuously and answer a few questions each day about your activities until labor starts. PI: Dr. Elise Erickson, Ph.D., CNM; IRB#20059 Target High-Throughput Methylome Analysis of Early and Late Onset Preeclampsia The purpose of this study is to examine the genetic differences in early preeclampsia and late preeclampsia pregnancies of mothers and their babies and how those differences compare to women who do not have preeclampsia. PI: Kent Thornburg, PhD, IRB #19294 Chronic hypertension and pregnancy This study is being done to evaluate what the best and safest treatment for mild chronic hypertension during pregnancy is for both mother and baby. PI: Leonardo Pereira, MD, MCR; IRB# 17011 Maternal well-being study We are interested in working with pregnant women to reduce mood symptoms and promote well-being during pregnancy and postpartum. PI: Kristen Mackiewicz Seghete, PhD; IRB# 19004 Medical optimization and management of pregnancies with overt type 2 diabetes (MOMPOD) The purpose of this study is to learn about the safety and effectiveness of the study drug metformin when added to insulin treatment to help treat type 2 and early diagnosed diabetes in pregnancy. The study is trying to find out if metformin can be used safely in pregnancy to improve diabetes care and reduce problems at birth. PI: Amy Valent, DO; IRB #18438 Oxytocin receptor DNA methylation and postpartum maternal outcomes In this study we are tying to learn if genetics plays a role in why some women have too much bleeding after birth. We are also interested in knowing more about how women's physical and mental recovery goes in the first year after birth whether or not they have had too much bleeding and how it related to their genetics as well. PI: Elise Erickson, PhD, CNM; IRB# 18841 Placenta repository: A study of placental function in healthy and pathological pregnancies Our long term goal is to identify pregnancies that are at risk of poor outcomes and to develop methods for prevention and treatment. PI: Leonardo Pereira, MD; IRB# 16328 Prenatal environment and child Health (PEACH) study OHSU researchers are conducting a study that looks at how maternal diet and metabolic state during pregnancy might affect child brain development and behavior. You can help us by participating in our research. PI: Elinor Sullivan, PhD and Joel Nigg, PhD; IRB #18579 Roo study on mom and baby well-being We are looking for pregnant people who have experienced difficulties with low mood, anxiety or high stress levels. We hope to learn if mindfulness groups can promote well-being and self-care during pregnancy and support infant brain development. PI: Alice Graham, PhD; IRB #19166 Rosacea course fluctuations during pregnancy: A longitudinal observational study The purpose of this study is to characterize the course of rosacea severity throughout pregnancy. PI: Jon Hanifin, MD; IRB# 16647 VentFirst: A multicenter RCT of assisted ventilation during delayed cord clamping for micro-preemies The purpose of this study is to determine whether delaying clamping of the umbilical cord up to 120 seconds and assisting breathing for extremely premature babies during that time reduces intraventricular hemorrhage (bleeding in the brain). PI: Jamie B. Warren, MD, MPH; IRB#15777 Menopause Overactive bladder study The purpose of this research study is to determine if the urinary microbiome affects overactive bladder syndrome (OAB). Currently, not much is known about the cause of OAB. This study seeks to determine if bacteria in the urinary tract play a role in OAB. PI: Lisa Karstens, PhD and Rahel Nardos, MD; IRB # 10729 Remote mindfulness-education for women with provoked localized vulvodynia This is a study designed to learn more about the use of an online remote education and mindfulness practice program for the pain and anxiety associated with provoked localized vulvodynia. Participants will be randomized to one of two groups: online education seminars alone or mindfulness practice using the Headspace app in combination with the online education seminars. PI: Catherine Leclair, MD; IRB #18191 Incontinence and urogynecology Overactive bladder study The purpose of this research study is to determine if the urinary microbiome affects overactive bladder syndrome (OAB). Currently, not much is known about the cause of OAB; this study seeks to determine if bacteria in the urinary tract play a role in OAB. PI: Lisa Karstens, PhD and Rahel Nardos, MD; IRB # 10729 Heavy menstrual bleeding Liletta® IUD and heavy menstrual bleeding study The purpose of this study is to investigate the effectiveness of a hormonal IUD at treating very heavy menstrual bleeding. PI: Jeffrey Jensen, MD, MPH; IRB# 19016 Management of Pain from Endometriosis in Pre-Menopausal Women The Women’s Health Research Unit is conducting a study to evaluate the safety and effectiveness of a new investigational medication, Linzagolix, for pain in women with endometriosis. PI: Jeffrey Jensen, MD, MPH; IRB# 19890. Other areas of women's health OHSU employees' opinions of clinical research The goal of this study is to identify how employees feel regarding their participation in clinical research. PI: Jeffrey Jensen, MD, MPH; IRB #: 17248 Remote mindfulness-education for women with provoked localized vulvodynia This is a study designed to learn more about the use of an online remote education and mindfulness practice program for the pain and anxiety associated with provoked localized vulvodynia. Participants will be randomized to one of two groups: online education seminars alone or mindfulness practice using the Headspace app in combination with the online education seminars. PI: Catherine Leclair, MD; IRB #18191 Web search and women's health study The purpose of this study is to learn more about how women use the internet to search for information relating to topics of women’s health such as abortion and C-section. This study also wants to learn what types of internet sources women use most frequently and what sources they find most trustworthy. PI: Leo Han, MD, MPH; IRB# 19117 TelAbortion study The purpose of this study is to assess service provision of medical abortion through telemedicine. IRB# 15974 Management of Pain from Endometriosis in Pre-Menopausal Women The Women’s Health Research Unit is conducting a study to evaluate the safety and effectiveness of a new investigational medication, Linzagolix, for pain in women with endometriosis. PI: Jeffrey Jensen, MD, MPH; IRB# 19890. Women's and gynecologic cancers In partnership with the Knight Cancer Institute Find current trials involving ovarian, uterine and cervical cancers