Endometrial Biopsy in Progestin Contraceptive Users

EB Progestin

This study is investigating why some people who use progestin-only contraception, such as the contraceptive implant (Nexplanon) or contraceptive injectable (Depo-Provera), have changes to their menstrual bleeding patterns. As part of this study, you will receive your choice of the contraceptive implant or contraceptive injectable. Participation will last up to 13 months and will involve 5 or 6 visits to our clinic at OHSU as well as 8 or 9 monthly phone call or email check-ins. You will be asked to allow us to collect a tissue sample from the lining of your uterus (endometrial biopsy) at 4 time points over the course of 12 months.


  • You are between 18 and 40 years of age
  • You have regular menstrual periods 
  • You have a Body Mass Index (BMI) between 19-35
  • You are not currently using hormonal contraceptives or gender-affirming hormonal treatment
  • You are not currently using an intrauterine device or intrauterine system (IUD or IUS)
  • You are seeking the contraceptive implant (Nexplanon) or contraceptive injectable (Depo-Provera)
  • You are not currently pregnant or planning pregnancy during the study


Qualified participants will receive all study related materials and exams at no charge and will be compensated up to $1,505 for their time and travel. The exact amount will depend on the number of visits and study requirements completed.

Contact Information:

To find out more information and to learn if you are qualified to participate, fill out the online form, or call the Women’s Health Research Unit confidential recruitment line: 503-494-3666.