Dr. Orloff's clinical interests include benign and malignant liver, gall bladder and bile duct tumors, liver, kidney, and pancreas transplantation, hepatobiliary and pancreatic surgery, portal hypertension surgery, organ procurement, hepatocellular carcinoma, cholangiocarcinoma, and benign hepatobiliary diseases.
Dr. Susan L. Orloff is professor of surgery and the director and chief of the Division of Abdominal Transplantation at Oregon Health & Science University. She is also chief of the Liver Transplantation Program at Portland VA Medical Center.
Dr. Orloff received a B.A. in biology, graduating Phi Beta Kappa in her home-town of La Jolla, at the University of California, San Diego. She then received her M.D. degree, graduating AOA, from the University of California, San Francisco in 1984. She started out in a residency at UCSF in internal medicine, but after one year, was bitten by the surgery bug, and was accepted into the general surgery residency at UCSF, completing her residency in 1992. During her general surgery residency, she spent two years in the Gastrointestinal Research Laboratory of Dr. Haile Debas, at that time the chair of surgery, as an awardee of an NIH training grant. She also spent four months in the Department of Surgery Research Laboratory of then chair, Dr. Bernard Jaffe, at SUNY Downstate, where she learned models of small bowel transplantation in rodents and dogs. After her general surgery residency, she went on to do a fellowship in multiorgan transplantation at UCSF, under the directorship of Dr. Nancy Ascher, completing this in December 1994.
Dr. Susan Orloff joined Oregon Health and Science University in 1995, where she has been actively engaged in research, teaching, multiorgan transplantation and hepatobiliary surgery. As professor of surgery, she holds joint appointments in the Division of Abdominal Transplantation and the Department of Molecular Microbiology and Immunology. From 2002-2005, Dr. Orloff served as the medical director for the Pacific Northwest Transplant Bank, and she has been the director of basic science research for the OHSU Department of Surgery since 2001.
Dr. Orloff established, and now supervises, a highly productive NIH- and VA merit review-funded laboratory in transplantation biology and immunology where she mentors post-doctoral fellows, Ph.D. graduate students and general surgery residents.
Currently, she has a busy practice in hepatobiliary surgery and multi-organ abdominal transplantation. She is also director of basic science research in the Department of Surgery and, for 12 years, has run an NIH-funded laboratory studying the mechanisms and genomics of CMV accelerated vasculopathy in heart and kidney transplant rodent models. She also has a research interest in the epidemiology, screening, treatments and genomics of hepatocellular carcinoma. She has over 90 peer-reviewed publications and 18 book chapters, and has presented her work locally, nationally and internationally. She serves as a reviewer for 16 journals and is on the editorial board of three.
She is an active member of numerous surgical societies as well as serving on many institutional, regional and national committees, including serving as the American Surgical Association Governor to the American College of Surgeons. She is past president of the Portland Surgical Society, and previous medical director of the Pacific Northwest Transplant Bank.
She currently resides in Portland, Oregon on the lovely Willamette River with her husband Dr. Robert Hart, and their eight-year old son Jackson.
- M.D., University of California Medical Center, San Fransico, San Francisco California USA 1984
- General aurgery, University of California, San Francisco, Medical Center, San Francisco, CA 1986-1992
- Visiting fellow, Department of Surgery, State University of New York Health Science Center at Brooklyn, NY 1989
- Surgery, American Board of Surgery, 1993
Memberships and associations
- American Hepato-Pancreato-Biliary Association
- "A 27-year experience with surgical treatment of Budd-Chiari syndrome" Annals of Surgery 2000
- "Cytomegalovirus microRNA expression is tissue specific and is associated with persistence" Journal of Virology January 2011
- "Differential trophic regulation of cultured fetal gastric epithelial cells by amniotic fluid peptide factors" Surgical Forum 1989
- "Rat cytomegalovirus-accelerated transplant vascular sclerosis is reduced with mutation of the chemokine-receptor R33" American Journal of Transplantation March 2005
- "Geographic differences in disease expression of cryptococcosis in solid organ transplant recipients in the United States" Annals of Transplantation 2010
- "Management of symptomatic polycystic liver disease with hepatic resection" JAMA Surgery January 1 2015
- "The international normalized ratio overestimates coagulopathy in patients after major hepatectomy" American Journal of Surgery 2014
- "Hepatitis C infection increases the risk of new-onset diabetes after transplantation in liver allograft recipients" American Journal of Surgery May 2005
- "Survey" JAMA Surgery 1990
- "Commentary" Surgery (United States) March 2013
- "Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing" Journal of Virology July 2008
- "Clonal deletion is one mechanism responsible for tolerance in mixed hematopoietic chimeras" Transplantation Proceedings 1997
- "Alcoholic versus nonalcoholic cirrhosis in a randomized controlled trial of emergency therapy of bleeding varices" Journal of Surgical Research May 1 2012
- "An unusual presentation of altered mental status after orthotopic liver transplantation" Transplantation June 27 2013
- "Neointimal hyperplasia in balloon-injured rat carotid arteries" Journal of Vascular Surgery January 2002
- "Budd-Chiari syndrome and venoocclusive disease" 2012
- "Central nervous system cryptococcosis in solid organ transplant recipients" Transplantation September 15 2008
- "Intestinal acid inhibits gastric acid secretion by neural and hormonal mechanisms in rats" American Journal of Physiology - Renal Fluid and Electrolyte Physiology 1992
- "Financial incentives for cadaver organ donation" Transplantation April 27 2002
- "Improved human pancreatic islet isolation for a prospective cohort study of islet transplantation vs best medical therapy in type 1 diabetes mellitus" JAMA Surgery August 2005
- "When is liver transplant indicated in cirrhosis with bleeding varices?" Transplantation Proceedings 2001
- "Induction of tolerance to small bowel allotransplants by mixed allogeneic chimerism" Transplantation Proceedings 1994
- "Cytomegalovirus (CMV)-accelerated Transplant Vascular Sclerosis (TVS)" FASEB Journal March 20 1998
- "Discussion" Journal of the American College of Surgeons July 2012
- "The role of cytomegalovirus in angiogenesis" Virus Research May 2011
- "Keeping high model for end-stage liver disease score liver transplantation candidates alive" Liver Transplantation November 1 2015
- "Cytomegalovirus CC chemokine promotes immune cell migration" Journal of Virology November 2012
- "A role for calcitonin gene-related peptide in protection against gastric ulceration" Annals of Surgery January 1994
- "The role of tumor ablation in bridging patients to liver transplantation" JAMA Surgery August 2004
- "Disability index in a randomized controlled trial of emergency sclerotherapy versus portacaval shunt for bleeding varices in cirrhosis" American Journal of Surgery August 2012