Photo of Sudarshan Anand, Ph.D.

Sudarshan Anand Ph.D.

    • Associate Professor of Cell, Developmental and Cancer Biology School of Medicine
    • Cell and Developmental Biology Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. Sudarshan Anand graduated with a PhD in Immunology from Johns Hopkins University School of Medicine in 2007 working on TNF superfamily immune costimulation. He was a postdoctoral scholar at the Moores Cancer Center at the University of California, San Diego from 2007-2014 where he investigated the role of microRNAs in tumor angiogenesis. He joined the department of Cell, Developmental Cancer Biology as an Assistant professor in March 2014.

Research Program:

The overall goal of the Anand lab is to understand how non-coding RNAs shape tumor responses to therapies such as radiation that work by inducing DNA damage. We focus on the cells in the tumor microenvironment in breast and colorectal cancers, particularly, the tumor blood vessels and immune cells to elucidate their contributions to the tumor progression and treatment responses. Using a combination of preclinical mouse models, human patient samples and cell culture models, we strive to address knowledge gaps, develop therapeutic strategies and identify biomarkers for patient stratification.

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Areas of interest

  • MicroRNA, Cancer, Tumor Microenvironment, Cell Engineering

Education

  • Ph.D., Johns Hopkins University, Baltimore Maryland 2007

Publications

  • "Herpesvirus entry mediator regulates hypoxiainducible factor-1α and erythropoiesis in mice" Journal of Clinical Investigation December 1 2011
  • "Control of autoimmune diseases by the B7-CD28 family molecules" Current Pharmaceutical Design  2004
  • "Kinase-independent role for CRAF-driving tumour radioresistance via CHK2" Nature Communications September 3 2015
  • "Expression of anti-HVEM single-chain antibody on tumor cells induces tumor-specific immunity with long-term memory" Cancer Immunology and Immunotherapy February 2012
  • "A MEK-independent role for CRAF in mitosis and tumor progression" Nature Medicine December 2011
  • "EGFR-dependent pancreatic carcinoma cell metastasis through Rap1 activation" Oncogene May 31 2012
  • "EGFR-mediated carcinoma cell metastasis mediated by integrin αvβ5 depends on activation of c-Src and cleavage of MUC1" PLoS One May 7 2012
  • "Emerging Role of Micro-RNAs in the Regulation of Angiogenesis" Genes and Cancer December 2011
  • "B7-H1/CD80 interaction is required for the induction and maintenance of peripheral T-cell tolerance" Blood August 26 2010
  • "Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease" Blood May 1 2007
  • "Disruption of angiogenesis and tumor growth with an orally active drug that stabilizes the inactive state of PDGFRβ/B-RAF" Proceedings of the National Academy of Sciences of the United States of America March 2 2010
  • "Manipulating MicroRNAs to regulate macrophage polarization in gliomas" Journal of the National Cancer Institute August 1 2014
  • "Essential role of TNF family molecule LIGHT as a cytokine in the pathogenesis of hepatitis" Journal of Clinical Investigation April 1 2006
  • "B7-H4-deficient mice display augmented neutrophil-mediated innate immunity" Blood February 19 2009
  • "An integrin β 3-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition" Nature Cell Biology  2014
  • "MicroRNA-mediated regulation of the angiogenic switch" Current Opinion in Hematology May 2011
  • "A brief primer on microRNAs and their roles in angiogenesis" Vascular Cell  2013
  • "MicroRNA-132-mediated loss of p120RasGAP activates the endothelium to facilitate pathological angiogenesis" Nature Medicine August 2010
  • "Ras pathway inhibition prevents neovascularization by repressing endothelial cell sprouting" Journal of Clinical Investigation November 1 2013
  • "MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment" Nature Communications November 25 2016
  • "Colorectal Cancer Liver Metastasis" Cellular and Molecular Gastroenterology and Hepatology March 1 2017
  • "Understanding and Resetting Radiation Sensitivity in Rectal Cancer" Annals of Surgery July 24 2017
  • "microRNA-451a regulates colorectal cancer proliferation in response to radiation" BMC Cancer May 3 2018
  • "MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling article" Cell Death and Disease June 1 2018
  • "Integrin CD11b activation drives anti-tumor innate immunity" Nature Communications December 1 2018
  • "MicroRNAs in Cancer" Current Pathobiology Reports March 1 2017

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