Photo of Richard Goodman, M.D., Ph.D.

Richard Goodman M.D., Ph.D.

  •      (503) 494-5409
    • Professor Vollum Institute
    • Senior Scientist Vollum Institute
    • Biochemistry and Molecular Biology Graduate Program School of Medicine
    • Cancer Biology Graduate Program School of Medicine
    • Cell and Developmental Biology Graduate Program School of Medicine
    • Neuroscience Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Richard Goodman is a senior scientist in the Vollum Institute. He also holds appointments as professor of Cell, Developmental and Cancer Biology and Biochemistry and Molecular Biology. After receiving his B.S. degree in Chemistry at the Massachusetts Institute of Technology, he entered the Medical Scientist Training Program at the University of Pennsylvania. He received his M.D. and Ph.D. degrees in 1976. Goodman trained in clinical medicine at Tufts-New England Medical Center from 1976 to 1978 and was an endocrinology fellow at New England Medical Center and Massachusetts General Hospital. He has been at the Vollum since 1990 and served as the Institute's director from 1990 until 2016.

Dr. Goodman's contributions include the characterization of the cAMP regulated enhancer (CRE), identification of the CREB coactivator, CBP, and one of the first genome-wide analyses of transcription factor binding sites in metazoan cells. He has trained 14 graduate students and 29 fellows, many of whom have gone on to have successful careers as independent investigators.

Areas of interest

  • metabolic regulation of gene expression
  • characterization of activity-regulated genes

Education

  • B.S., Massachusetts Institute of Technology, Cambridge Massachusetts 1970
  • M.D., University of Pennsylvania, Philadelphia Pennsylvania 1976
  • Ph.D., University of Pennsylvania, Philadelphia Pennsylvania 1976

Honors and awards

  • National Academy of Sciences, elected member (2002)
  • Institute of Medicine, elected member (2005)
  • Scientific Review Board, Howard Hughes Medical Institute (2008-2011)
  • Director of the Vollum Institute (1990-2016)

Publications

  • "Prosomatostatin-specific antigen in rat brain" Proceedings of the National Academy of Sciences of the United States of America  1983
  • "Modulation of sodium-channel mRNA levels in rat skeletal muscle." Proceedings of the National Academy of Sciences of the United States of America December 1987
  • "Structure of a precursor to human pancreatic polypeptide" Journal of Biological Chemistry  1984
  • "High plasma levels of immunoreactive somatostatin in transgenic mice expressing a metallothionein-somatostatin fusion gene." Transactions of the Association of American Physicians  1984
  • "Cell-type-specific binding of the transcription factor CREB to the cAMP-response element" Proceedings of the National Academy of Sciences of the United States of America September 14 2004
  • "Genomic organization and deduced amino acid sequence of a putative sodium channel gene in Drosophila" Science  1987
  • "Capturing microRNA targets using an RNA-induced silencing complex (RISC)-trap approach" Proceedings of the National Academy of Sciences of the United States of America December 11 2012
  • "Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active" Proceedings of the National Academy of Sciences of the United States of America October 1 1993
  • "Treatment planning at the neutron facility of the hospital of the University of Pennsylvania and the hospital of the Fox Chase Cancer Center in Philadelphia" Strahlentherapie und Onkologie  1981
  • "Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling" Nature April 17 1997
  • "The CGTCA sequence motif is essential for biological activity of the vasoactive intestinal peptide gene cAMP-regulated enhancer" Proceedings of the National Academy of Sciences of the United States of America  1988
  • "MicroRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus" Proceedings of the National Academy of Sciences of the United States of America November 23 2010
  • "Eosinophilic granuloma mimicking a pituitary tumor" Neurosurgery  1979
  • "Protein kinase a directly regulates the activity and proteolysis of cubitus interruptus" Proceedings of the National Academy of Sciences of the United States of America March 3 1998
  • "Modulatory function of CREB·CREMα heterodimers depends upon CREMα phosphorylation" Journal of Biological Chemistry November 18 1994
  • "Surgical cure of prolactinoma reverses abnormal prolactin response to carbidopa/L-dopa" Journal of Clinical Endocrinology and Metabolism  1982
  • "Defining the CREB regulon" Cell December 29 2004
  • "Cyclic AMP regulates somatostatin mRNA accumulation in primary diencephalic cultures and in transfected fibroblast cells" Journal of Neuroscience  1986
  • "A β-catenin/TCF-coordinated chromatin loop at MYC integrates 5′ and 3′ Wnt responsive enhancers" Proceedings of the National Academy of Sciences of the United States of America  2010
  • "A genome-wide screen for β-catenin binding sites identifies a downstream enhancer element that controls c-Myc gene expression" Molecular and Cellular Biology December 2008
  • "The β-adrenergic receptor kinase interacts with the amino terminus of the G protein β subunit" Biochemical and Biophysical Research Communications November 17 1997
  • "Fluorescence polarization analysis of protein-DNA and protein-protein interactions" Molecular Endocrinology  1996
  • "MicroRNA-134 activity in somatostatin interneurons regulates H-Ras localization by repressing the palmitoylation enzyme, DHHC9" Proceedings of the National Academy of Sciences of the United States of America October 29 2013
  • "Regulation of corepressor function by nuclear NADH" Science March 8 2002
  • "Rat pre-prosomatostatin. Structure and processing by microsomal membranes" Journal of Biological Chemistry  1983
  • "Epigenetic mechanisms and gene networks in the nervous system" Journal of Neuroscience November 9 2005
  • "Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA" Nature Neuroscience December 2007
  • "Pancreatic pre-proglucagons are encoded by two separate mRNAs." Journal of Biological Chemistry July 10 1981
  • "Structure of the human vasoactive intestinal polypeptide gene" DNA and Cell Biology  1985
  • "Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice" Science  1986

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