Quin Denfeld, P.h.D., R.N.

  • Assistant Professor, School of Nursing


My main research interest involves studying the biological mechanisms that give rise to symptoms and physical frailty among adults with heart failure (“symptom biology”) that, in turn, affect outcomes such as quality of life and clinical events. In my prior research (F31NR015936), I demonstrated that physical frailty is highly prevalent in heart failure and reflects worse functional, hemodynamic, cognitive, and symptomatic parameters. My post-doctoral area of research (T32HL094294) focused on studying dysregulation of the sympathetic nervous system in heart failure, specifically centered on changes surrounding beta-adrenergic receptors (i.e. beta-adrenergic receptor kinase-1) and catecholamines, and how this relates to quality-of-life. A parallel research interest involves examining novel biomarkers (i.e. sST2) and undiscovered biomarkers using proteomics to identify patients with heart failure who will have better or worse patient-oriented and clinical outcomes. I am currently funded (K12HD043488) to study gender differences in physical frailty in heart failure, including gender differences in the mechanisms underlying physical frailty in heart failure and in the resultant outcomes. The goal of my research is to identify, and eventually target, specific markers in guiding the clinical management of heart failure patients as a means to improving overall quality of life. As a former critical care nurse at OHSU, I am also passionate about leveraging the knowledge and skillsets of nurses to research innovative questions and accelerate the translation of findings from bench-to-bedside-to-community. 


  • B.S.N., 2005, Linfield College
  • Ph.D., 2016, Oregon Health & Science University
  • Fellowship:

    • Post-Doctoral Fellowship, Habecker Lab, OHSU Knight Cardiovascular Institute (2016-2017)

Memberships and associations

  • American Heart Association
  • Heart Failure Society of America
  • American Physiological Society
  • The International Society for Heart & Lung Transplantation

Areas of interest

  • Heart Failure
  • Frailty
  • Symptoms
  • Biomarkers


Selected publications

  • Recent publications:
  • Denfeld, Q.E. & Lee, C.S. (2018) The Crossroads of frailty and heart failure: What more can we learn? [Editorial] J Card Fail, 24(11):733-734
  • Denfeld, Q.E., Mudd, J.O., Hasan, W., Gelow, J.M., Hiatt, S.O., Winters-Stone, K., & Lee, C.S. (2018) Exploring the relationship between β-adrenergic receptor kinase-1 and physical symptoms in heart failure. Heart Lung, 47(4), 281-284
  • Denfeld, Q.E., Habecker, B.A., & Woodward, W.R. (2018) Measurement of plasma norepinephrine and 3,4-dihydroxyphenylglycol: Method development for a translational research study. BMC Research Notes, 11(1), 248
  • Denfeld, Q.E., Winters-Stone, K., Mudd, J.O., Hiatt, S.O., & Lee, C.S. (2018) Identifying a relationship between physical frailty and heart failure symptoms. J Cardiovasc Nurs, 33(1), E1-E7
  • Denfeld, Q.E., Winters-Stone, K., Mudd, J.O., Gelow, J.M., Kurdi, S., & Lee, C.S. (2017) The prevalence of frailty in heart failure: A systematic review and meta-analysis. Int J Cardiol, 236, 283-289
  • Denfeld, Q.E., Winters-Stone, K., Mudd, J.O., Hiatt, S.O., Chien, C.V., & Lee, C.S. (2017) Frequency of and significance of physical frailty in patients with heart failure. Am J Cardiol, 119(8), 1243-1249


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