Photo of Owen J.T. McCarty, Ph.D.

Owen J.T. McCarty Ph.D.

  • (503) 418-9307

    Portland Campus

    • Professor of Biomedical Engineering School of Medicine
    • Chair Biomedical Engineering School of Medicine
    • Cell and Developmental Biology Graduate Program School of Medicine
    • Biomedical Engineering Graduate Program School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine

Dr. McCarty received his Ph.D in Chemical & Biomolecular Engineering from Johns Hopkins University with dissertation work focused on the role of platelets in cancer metastasis and thrombosis. As a Wellcome Trust Postdoctoral Fellow, he continued his research in the area of thrombosis, examining the signaling pathways governing platelet cytoskeleton reorganization, at the Department of Pharmacology, Oxford University and Centre for Cardiovascular Sciences, University of Birmingham, UK.

Areas of interest

  • Dr. McCarty's research is focused on understanding the interplay between cell biology and fluid mechanics in the cardiovascular system. In particular, his research into the balance between hydrodynamic shear forces and chemical adhesive interactions has great relevance to underlying processes of cancer, cardiovascular disease, and inflammation.

Education

  • B.S., State University of New York 1997
  • Ph.D., Johns Hopkins University 2002

Publications

Selected publications

  • Verhoef JJF, Barendrecht AD, Nickel KF, de Maat S, Keene E, Labberton L, McCarty OJ, Schiffelers R, Heijnen HF, Hendrickx AP, Schellekens H, Fens MH, Renne T, Maas C. Polyphosphate nanoparticles on the platelet surface trigger contact system activation. Blood 2017;129(12):1707-1717. (with Editorial; Cover)

  • Mitrugno A, Sylman JL, Ngo AT, Pang J, Sears RC, Williams CD, McCarty OJ. Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: implications for the oncoprotein c-MYC. American Journal of Physiology: Cell Physiology 2017 Feb 1;312(2):C176-C189. (Selected as the AJP: Cell Image of the Week; Featured in AJP News)

  • Zilberman-Rudenko J, Sylman JL, Lakshmanan HH, McCarty OJ*, Maddala J*. Dynamics of blood flow and thrombus formation in a multi-bypass microfluidic ladder network. Cellular and Molecular Bioengineering 2017 Feb;10(1):16-29. *equally contributing senior authors (with Editorial)

  • Zilberman-Rudenko J, Itakura A, Maddala J, Baker-Groberg SM, Vetter R, Tucker EI, Gruber A, Gerdes C, McCarty OJ. Biorheology of platelet activation in the bloodstream distal to thrombus formation. Cellular and Molecular Bioengineering 2016 Dec;9(4):496-508.

Publications

  • "Role of coagulation in the recruitment of colon adenocarcinoma cells to thrombus under shear" American Journal of Physiology - Renal Fluid and Electrolyte Physiology November 1 2013
  • "GPVI and integrin αIIbβ3 signaling in platelets" Journal of Thrombosis and Haemostasis  2005
  • "Single molecule characterization of P-selectin/ligand binding" Journal of Biological Chemistry March 21 2003
  • "MyosinIIa contractility is required for maintenance of platelet structure during spreading on collagen and contributes to thrombus stability" Journal of Thrombosis and Haemostasis October 2007
  • "Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells" Proceedings of the National Academy of Sciences of the United States of America January 6 2009
  • "p21-Activated Kinase (PAK) Regulates Cytoskeletal Reorganization and Directional Migration in Human Neutrophils" PLoS One September 3 2013
  • "Prevention of vascular graft occlusion and thrombus-associated thrombin generation by inhibition of factor XI" Blood January 22 2009
  • "GPVI potentiation of platelet activation by thrombin and adhesion molecules independent of Src kinases and Syk" Arteriosclerosis, Thrombosis, and Vascular Biology February 2007
  • "Activated factor XI inhibits chemotaxis of polymorphonuclear leukocytes" Journal of Leukocyte Biology November 2011
  • "Development of coagulation factor probes for the identification of procoagulant circulating tumor cells" Frontiers in Oncology  2012
  • "Rho GTPases in platelet function" Journal of Thrombosis and Haemostasis January 2013
  • "Evaluation of the role of platelet integrins in fibronectin-dependent spreading and adhesion" Journal of Thrombosis and Haemostasis October 2004
  • "A physical sciences network characterization of non-tumorigenic and metastatic cells" Scientific Reports  2013
  • "Capture of flowing endothelial cells using surface-immobilized anti-kinase insert domain receptor antibody" Tissue Engineering - Part C: Methods  2008
  • "Data detailing the platelet acetyl-lysine proteome" Data in Brief December 1 2015
  • "Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets" Journal of Molecular Signaling September 1 2011
  • "Factor XII promotes blood coagulation independent of factor XI in the presence of long-chain polyphosphates" Journal of Thrombosis and Haemostasis July 2013
  • "Effect of Ionizing Radiation on the Physical Biology of Head and Neck Squamous Cell Carcinoma Cells" Cellular and Molecular Bioengineering September 21 2015
  • "A theme series on physical biology in cancer in AJP-cell" American Journal of Physiology - Renal Fluid and Electrolyte Physiology January 15 2014
  • "Rational design of an ex vivo model of thrombosis" Cellular and Molecular Bioengineering June 2010
  • "Evaluation of platelet antagonists in in vitro flow models of thrombosis." Methods in molecular medicine  2004
  • "Hyaluronan anchored to activated CD44 on central nervous system vascular endothelial cells promotes lymphocyte extravasation in experimental autoimmune encephalomyelitis" Journal of Biological Chemistry September 28 2012
  • "Distinct extracellular matrix microenvironments of progenitor and carotid endothelial cells" Journal of Biomedical Materials Research - Part B Applied Biomaterials November 2009
  • "Protein C supports platelet binding and activation under flow" Journal of Thrombosis and Haemostasis June 2008
  • "Safety and antithrombotic efficacy of moderate platelet count reduction by thrombopoietin inhibition in primates" Science Translational Medicine June 23 2010
  • "Spatial distribution of factor xa, thrombin, and fibrin(ogen) on thrombi at venous shear" PLoS One  2010
  • "Histone deacetylase 6-mediated deacetylation of α-tubulin coordinates cytoskeletal and signaling events during platelet activation" American Journal of Physiology - Renal Fluid and Electrolyte Physiology December 15 2013
  • "S6K1 and mTOR regulate Rac1-driven platelet activation and aggregation" Blood September 15 2011
  • "Thrombin mutant W215A/E217A acts as a platelet GPIb antagonist" Arteriosclerosis, Thrombosis, and Vascular Biology February 2008
  • "γA/γ′ fibrinogen inhibits thrombin-induced platelet aggregation" Thrombosis and Haemostasis November 2008

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