Dr. McCarty received his Ph.D in Chemical & Biomolecular Engineering from Johns Hopkins University with dissertation work focused on the role of platelets in cancer metastasis and thrombosis. As a Wellcome Trust Postdoctoral Fellow, he continued his research in the area of thrombosis, examining the signaling pathways governing platelet cytoskeleton reorganization, at the Department of Pharmacology, Oxford University and Centre for Cardiovascular Sciences, University of Birmingham, UK.
Areas of interest
- Dr. McCarty's research is focused on understanding the interplay between cell biology and fluid mechanics in the cardiovascular system. In particular, his research into the balance between hydrodynamic shear forces and chemical adhesive interactions has great relevance to underlying processes of cancer, cardiovascular disease, and inflammation.
- B.S., State University of New York 1997
- Ph.D., Johns Hopkins University 2002
Verhoef JJF, Barendrecht AD, Nickel KF, de Maat S, Keene E, Labberton L, McCarty OJ, Schiffelers R, Heijnen HF, Hendrickx AP, Schellekens H, Fens MH, Renne T, Maas C. Polyphosphate nanoparticles on the platelet surface trigger contact system activation. Blood 2017;129(12):1707-1717. (with Editorial; Cover)
Mitrugno A, Sylman JL, Ngo AT, Pang J, Sears RC, Williams CD, McCarty OJ. Aspirin therapy reduces the ability of platelets to promote colon and pancreatic cancer cell proliferation: implications for the oncoprotein c-MYC. American Journal of Physiology: Cell Physiology 2017 Feb 1;312(2):C176-C189. (Selected as the AJP: Cell Image of the Week; Featured in AJP News)
Zilberman-Rudenko J, Sylman JL, Lakshmanan HH, McCarty OJ*, Maddala J*. Dynamics of blood flow and thrombus formation in a multi-bypass microfluidic ladder network. Cellular and Molecular Bioengineering 2017 Feb;10(1):16-29. *equally contributing senior authors (with Editorial)
Zilberman-Rudenko J, Itakura A, Maddala J, Baker-Groberg SM, Vetter R, Tucker EI, Gruber A, Gerdes C, McCarty OJ. Biorheology of platelet activation in the bloodstream distal to thrombus formation. Cellular and Molecular Bioengineering 2016 Dec;9(4):496-508.