Photo of Monika Davare, Ph.D.

Monika Davare Ph.D.

  •      (503) 494-5056
    • Assistant Professor of Pediatrics, Division of Hematology and Oncology School of Medicine
    • Program in Molecular and Cellular Biosciences School of Medicine
    • Cancer Biology Graduate Program School of Medicine

The Davare laboratory’s research goals are directed towards overcoming the therapeutic bottleneck in rare but aggressive pediatric and adult cancers. Oncogenomics-driven big data approaches effectively identify lead drug targets for cancer, but bottlenecks arise from a lack or slower pace of functionally testing, vetting and optimizing leads for therapeutic development. Using complementary in vitro and in vivo experimental model systems coupled with patient-derived genomic data, we have successfully identified driving kinase pathways and validated small-molecule inhibitor therapies for targeting distinct genomic subsets of glioblastoma, sarcoma, medulloblastoma and non-small cell lung cancer. We have active cross-institutional collaborations with clinical oncologists to facilitate transfer of our bench discoveries into clinical trials and as needed, validate clinical findings back at the bench. I combine my expertise and experience in the areas of kinase biology, cell surface receptors, and ion channel physiology with my background in molecular pharmacology to lead this translational research program.

Education

  • B.A., University of Maine (Zoology/Philosophy), Orono Maine 1995
  • Ph.D., University of Wisconsin-Madison (Molecular and Cellular Pharmacology), Madison Wisconsin 2000

Publications

  • "Calmodulin-kinases regulate basal and estrogen stimulated medulloblastoma migration via Rac1" Journal of Neuro-Oncology August 2011
  • "Small molecule inhibitor screen identifies synergistic activity of the bromodomain inhibitor CPI203 and bortezomib in drug resistant myeloma" Oncotarget  2015
  • "Functional RNAi screen targeting cytokine and growth factor receptors reveals oncorequisite role for interleukin-2 gamma receptor in JAK3-mutation-positive leukemia" Oncogene June 4 2015
  • "Regulation of Axonal Extension and Growth Cone Motility by Calmodulin-Dependent Protein Kinase I" Journal of Neuroscience April 14 2004
  • "Follicle-stimulating hormone activates extracellular signal-regulated kinase but not extracellular signal-regulated kinase kinase through a 100-kDa phosphotyrosine phosphatase" Journal of Biological Chemistry February 28 2003
  • "Long-term potentiation-dependent spine enlargement requires synaptic Ca2+-permeable AMPA receptors recruited by CaM-kinase I" Journal of Neuroscience September 1 2010
  • "An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling" Molecular and Cellular Neuroscience January 2010
  • "Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors" Proceedings of the National Academy of Sciences of the United States of America September 29 2015
  • "Secreted meningeal chemokines, but not VEGFA, modulate the migratory properties of medulloblastoma cells" Biochemical and Biophysical Research Communications July 18 2014
  • "Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins" Proceedings of the National Academy of Sciences of the United States of America November 26 2013
  • "A Genome-Wide Screen of CREB Occupancy Identifies the RhoA Inhibitors Par6C and Rnd3 as Regulators of BDNF-Induced Synaptogenesis" PLoS One June 6 2013
  • "Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target" Proceedings of the National Academy of Sciences of the United States of America November 26 2013
  • "An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP" Proceedings of the National Academy of Sciences of the United States of America July 1 2008
  • "Corrigendum to "An activity-induced microRNA controls dendritic spine formation by regulating Rac1-PAK signaling" [YMCNE (2010) 146-156]" Molecular and Cellular Neuroscience February 2012
  • "Transient receptor potential canonical 5 channels activate Ca 2+/calmodulin kinase Iγ to promote axon formation in hippocampal neurons" Journal of Neuroscience August 5 2009
  • "Inhibition of calcium/calmodulin-dependent protein kinase kinase by protein 14-3-3" Journal of Biological Chemistry December 10 2004
  • "Therapeutically targetable ALK mutations in leukemia" Journal of Cancer Research June 1 2015
  • "Activity-Dependent Synaptogenesis" Neuron January 10 2008
  • "Mitogen- and Stress-Activated Protein Kinase 1 Mediates cAMP Response Element-Binding Protein Phosphorylation and Activation by Neurotrophins" Journal of Neuroscience May 5 2004
  • "Bortezomib stabilizes NOXA and triggers ROS-associated apoptosis in medulloblastoma" Journal of Neuro-Oncology December 2011
  • "Analysis of CaM-kinase signaling in cells" Cell Calcium July 2011
  • "Preclinical testing of tandutinib in a transgenic medulloblastoma mouse model" Journal of Pediatric Hematology/Oncology March 2012
  • "Bidirectional regulation of cytoplasmic polyadenylation element-binding protein phosphorylation by Ca2+/calmodulin-dependent protein kinase II and protein phosphatase 1 during hippocampal long-term potentiation" Journal of Neuroscience June 8 2005
  • "A novel crizotinib-resistant solvent-front mutation responsive to cabozantinib therapy in a patient with ROS1-rearranged lung cancer" Clinical Cancer Research May 15 2016
  • "IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma" Scientific Reports June 3 2016
  • "Erratum" Science August 3 2001
  • "The A-kinase anchor protein MAP2B and cAMP-dependent protein kinase are associated with class C L-type calcium channels in neurons" Journal of Biological Chemistry October 15 1999
  • "Critical role of cAMP-dependent protein kinase anchoring to the L-type calcium channel Cav1.2 via A-kinase anchor protein 150 in neurons" Biochemistry February 13 2007
  • "Increased phosphorylation of the neuronal L-type Ca2+ channel Cav1.2 during aging" Proceedings of the National Academy of Sciences of the United States of America December 23 2003
  • "ERK activation and cell growth require CaM kinases in MCF-7 breast cancer cells" Molecular and Cellular Biochemistry February 2010

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