Miranda M. Lim, M.D., Ph.D. (she/her)
- Professor of Neurology, School of Medicine
- Professor of Behavioral Neuroscience, School of Medicine
- Professor of Medicine, Division of Pulmonary and Critical Care Medicine, School of Medicine
- Professor of Layton Aging and Alzheimer's Disease Center, School of Medicine
- Professor of OHSU Parkinson Center and Movement Disorders Program, School of Medicine
- Professor, Oregon Institute of Occupational Health Sciences
- Behavioral Neuroscience Graduate Program, School of Medicine
Biography
I am a physician-scientist and neurologist with board certification in Sleep Medicine. In addition to my faculty appointments at OHSU, I also hold a joint appointment at the VA Portland Health Care System. I served as Co-Director and Associate Director of the Oregon Alzheimer's Disease Research Center, one of several NIH NIA P30-funded centers nationwide. I am also Associate Co-Director of VA's Advanced Fellowship in Mental Illness Research and Treatment (MIRT) for VA's VISN20 Northwest Mental Illness Research Education and Clinical Center (MIRECC).
My research program, Sleep & Health Applied Research Program (SHARP), focuses on how sleep modulates neuropathological and behavioral outcomes in neurological disorders across the lifespan, including autism spectrum disorder, traumatic brain injury (TBI), posttraumatic stress disorder (PTSD), and aging/neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. My laboratory is known for its bidirectional, translational research spanning from preclinical rodent to human and epidemiological studies. My methodological expertise is in designing and conducting sleep studies (including nuanced sleep phenotyping, sleep manipulations, and sleep interventions), analysis of overnight EEG/EMG recordings during sleep, implementing non-obtrusive long-term wearables (e.g., actigraphy, mattress sensors), and performing quantitative EEG methodology including machine learning across both non-human animals and humans.
Over the years, our group has published peer-reviewed manuscripts in high-impact journals, including Nature, Science, PNAS, Journal of Clinical Investigation, Science Translational Medicine, Science Advances, and JAMA Neurology. We are supported by federal and non-federal sources, including VA (BLRD, CSRD, RRD), NIH (NIA, NIMH, NCCIH, NHLBI, NCATS, NIGMS), DoD, NSF, American Sleep Medicine Foundation, Pacific Northwest National Laboratory, Hartford Center for Gerontological Excellence, Oregon Roybal Center for Aging and Technology (ORCATECH), Parkinson’s Center of Oregon, Brain & Behavior Foundation (NARSAD), Oregon Medical Research Foundation, Oregon Institute of Occupational Health Sciences, Collins Medical Trust, and Portland VA Research Foundation.
Education and training
-
Degrees
- M.D., Ph.D., 2006, Emory University
-
Internship
- Preliminary Medicine, Barnes-Jewish Hospital, Washington University in Saint Louis, 2006-2007
-
Residency
- Neurology, Barnes-Jewish Hospital, Washington University in Saint Louis, 2007-2010
-
Fellowship
- Sleep Medicine, University of Pennsylvania, 2010-2013
-
Certifications
- Neurology, American Board of Psychiatry & Neurology, 2010-current
- Sleep Medicine, American Board of Internal Medicine, 2011-current
Areas of interest
- Sleep
- EEG
- Traumatic brain injury
- Post-traumatic stress disorder
- Neurodegeneration
- Alzheimer's
- Autism
- Parkinson's
Additional information
Honors and awards
- United States Presidential Early Career Award for Scientists and Engineers (PECASE), 2025
Publications
Selected publications
- Dagum P, Giovangrandi L, Levendovszky SR, Winebaum JJ, Singh T, Cho Y, Kaplan KM, Jaffe MS, Lim MM, Vandeweerd C, Iliff JJ (2025). A wireless device for continuous measurement of brain parenchymal resistance tracks glymphatic function in humans. Nature Biomedical Engineering. PMID: 40425804
- Elliott JE, Brewer JS, Keil AT, Ligman BR, Bryant-Ekstrand MD, McBride AA, Powers K, Sicard SJ, Twamley EW, O’Neil ME, Hildebrand AD, Nguyen T, Morasco BJ, Gill JM, Dengler BA, Lim MM (2025). Feasibility and acceptability for LION, a fully remote, randomized clinical trial within the VA for light therapy to improve sleep in Veterans with and without TBI. PLOSOne, PMID: 39775195
- Elliott JE, Ligman BR, Bryant-Ekstrand MD, Keil AT, Powers KA, Olivo C, Neilson LE, Postuma RB, ... Boeve BF, Ju YS, Lim MM (2024). Cognitive, motor and autonomic dysfunction are increased in idiopathic REM sleep behavior disorder with comorbid neurotrauma: A substudy of the North American Prodromal Synucleinopathy Consortium. SLEEP. PMID: 38181205
- Neilson LE, Quinn JF, Lim MM (2023). Screening and Targeting Risk Factors for Prodromal Synucleinopathy: A Prescriptive Multi-modal Framework. Aging & Disease. PMID: 37309872
- Scott GD, Neilson LE, Woltjer R, Quinn J, Lim MM (2023). Lifelong association of disorders related to military trauma with subsequent Parkinson's Disease. Movement Disorders. PMID: 37309872
- Bueno-Junior LS, Ruckstuhl M, Lim MM, Watson BO (2023). Defining the temporal structure of REM sleep: A minute-scale fluctuation across brain and body in mice and humans. PNAS. PMID: 37094161
- Elliott JE, Opel RA, Pleshakov D, Chau AQ, Rachakonda T, Weymann KB, Lim MM (2020). Post-traumatic stress disorder, with and without comorbid traumatic brain injury, increases the prevalence of rapid eye movement sleep behavior disorder in Veterans (2020). SLEEP. PMID: 31587047.
- Jones CE, Opel RA, Kaiser ME, Quintana J, Nipper MA, Finn DA, Hammock EAD*, Lim MM* (2019). Early life sleep disruption alters the developmental trajectory of cortical parvalbumin and impairs social bonding in prairie voles. Science Advances. PMID: 30729165
- Kang JE, Lim MM, Bateman RJ, Lee JJ, Smyth LP, Cirrito JR, Fujiki N, Nishino S, Holtzman DM (2009). Amyloid-beta dynamics are regulated by orexin and the sleep-wake cycle. Science. PMID: 19779148.
- Lim MM, Wang ZX, Olazabal DE, Ren XH, Terwilliger EF, and Young LJ (2004). Enhanced partner preference in a promiscuous species by manipulating the expression of a single gene. Nature. PMID: 15201909.