Photo of Michael Moldavan, Ph.D.

Michael Moldavan Ph.D.

Dr. Moldavan received his Bachelor of Science in Biology from Kyiv State University in Kyiv, Ukraine and his Ph.D. in Physiology from the Bogomoletz Institute of Kyiv, Ukraine in 1992. PhD Thesis: Reticular thalamic nucleus spike activity adjustments during conditioned instrumental reflex".

He is studying the modulation by presynaptic receptors of optic nerve signaling, the properties of the GABAA tonic current, and the contribution of GABA spill-over and GABA transporters to this current in the hypothalamic suprachiasmatic nucleus.

Study of the mechanisms underlying the GABAB receptor-mediated modulation of glutamate release from retinohypothalamic tract terminal in suprachiasmatic nucleus (SCN). Investigation of the role of the SCN in circadian rhythm regulation. Electrophysiological studies of sensorimotor, associate cortex and reticular thalamic nucleus neurons during conditioning; participation of caudate putamen (striatum) in motor control; electrophysiology and pharmacology of hippocampal, motor cortex and hypothalamic neurons (slices, in vitro studies).

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Areas of interest

  • Neural pathways mediating photic entrainment of the circadian clock in the suprachiasmatic nucleus (SCN).
  • Presynaptic GABAB- and orphanin FQ receptors-mediated inhibition of synaptic transmission in glutamatergic synapses formed by retinohypothalamic tract (RHT) axonal terminals on SCN neurons.
  • Glutamate release from RHT axonal terminals and RHT-SCN synaptic plasticity in vGlut2 KO mice.
  • How the biological active substances from hallucinogenic and medicinal mushrooms affect cell activity, growth and myelination of processes in neurons.

Education

  • Ph.D., Physiology, Bogomoletz Institute of Physiology, Kyiv, Ukrane 1992

Memberships and associations

  • Society for Neuroscience

Publications

  • Moldavan M, Cravetchi O., Allen C.N. GABA transporters regulate tonic and synaptic GABAA receptor-mediated currents in the suprachiasmatic nucleus neurons. Journal of Neurophysiology, 2017 Dec 1;118(6):3092-3106.

  • Wong K-H, Gryganskyi AP, Cheng P-G, Sabaratnam V, Kolotushkina OV, Kirchhoff B, Skibo GG, Pedarzani P, Voronin KY, Grodzinskaya AA, Moldavan M. "Lions Mane mushroom the natural healer for nerve damage" (p. 69 -104) in the monograph Macromycetes: medicinal properties and biological peculiarities edited by prof. S.P. Wasser, Kiev, April 2017, 261 p.

  • Moldavan M, Cravetchi O, Williams M., Irwin RP, Aicher SA, Allen CN Localization and expression of GABA transporters in the suprachiasmatic nucleus. European Journal of Neuroscience, 2015, 42(12): 3018-32.

  • Moldavan MG, Allen CN. GABAB receptor-mediated frequency-dependent and circadian changes in synaptic plasticity modulate retinal input to the Suprachiasmatic Nucleus. J Physiol 2013, 591(10): 2475-90.

  • Moldavan MG, Allen CN. Retinohypothalamic Tract Synapses in the Rat Suprachiasmatic Nucleus Demonstrate Short-term Synaptic Plasticity. J. Neurophysiol., 2010, 103. P. 2390-2399.

  • Moldavan MG, Irwin RP and Allen CN. Presynaptic GABAb receptors Regulate Retinohypothalamic Tract Synaptic Transmission by inhibiting Voltage-Gated Ca2+ Channels. J Neurophysiol. 2006, 95(6): 3727-41.

  • Gompf HS, Moldavan MG, Irwin RP, Allen CN. Nociceptin/orphanin FQ (N/OFQ) inhibits excitatory and inhibitory synaptic signaling in the suprachiasmatic nucleus (SCN). Neuroscience. 2005;132(4):955-965.

  • Kolotushkina E.V., Moldavan M.G., Voronin K.Yu., Skibo G.G. The influence of Hericium erinaceus extract on myelination process in vitro, Fiziol Zh., 2003.- 49 (1): 38-45.

  • Moldavan M.G. Spike reactions of neurons of the thalamic reticular nucleus of cat during instrumental conditioning. Neurophysiology,1991.- 23 (1): 8-18.

  • Sitnik K.M., Sheliag-Sosonko U.R., Kanevskiy V.A., Dima A.G., Melnikov D.I., Busel B.I., Moldavan M.G., Golovushkin M.I. Biotelemetry application in remote geophysical investigations. AN USSR Reports, 1985.- 282 (2): 291-295

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