Meaghan H. Hancock

  • Research Assistant Professor, VGTI-Vaccine and Gene Therapy Institute

Biography

Meaghan Hancock received her Bachelor of Science degree in Molecular Biology and Biotechnology from McMaster University, Hamilton, Ontario, Canada in 2004. During her undergraduate studies she worked in the laboratory of Dr. Karen Mossman studying viral mediated activation of IRF3. Her PhD research was conducted in the laboratory of Dr. Jim Smiley at the University of Alberta, Edmonton, Alberta, Canada where she studied the roles of herpes simplex virus proteins VP16 and ICP0 in overcoming innate barriers to viral gene expression. She began her post-doctoral training in the laboratory of Dr. Jay Nelson at the Vaccine and Gene Therapy Institute (VGTI), Oregon Health and Science University, studying the roles of human cytomegalovirus (CMV) miRNAs in modulating host cellular signaling pathways. In addition, she is using cellular miRNAs to alter CMV tropism in order to better understand the immune responses elicited by CMV-based vaccine vectors. She is currently a Research Assistant Professor at the VGTI.

Areas of interest

  • Studying the roles of human cytomegalovirus (CMV) miRNAs in modulating host cellular signaling pathways

Publications

Selected publications

  • Hancock MH, Hook LM, Mitchell J, Nelson JA. Human Cytomegalovirus MicroRNAs miR-US5-1 and miR-UL112-3p Block Proinflammatory Cytokine Production in Response to NF-κB-Activating Factors through Direct Downregulation of IKKα and IKKβ.  MBio. 2017 Mar 7;8(2). pii: e00109-17. doi: 10.1128/mBio.00109-17. [PMID: 28270578]
  • Burwitz BJ, Malouli D, Bimber BN, Reed JS, Ventura AB, Hancock MH, Uebelhoer LS, Bhusari A, Hammond KB, Espinosa Trethewy RG, Klug A, Legasse AW, Axthelm MK, Nelson JA, Park BS, Streblow DN, Hansen SG, Picker LJ, Früh K, Sacha JB. Cross-Species Rhesus Cytomegalovirus Infection of Cynomolgus Macaques. PLoS Pathog. 2016 Nov 9;12(11):e1006014. doi: 10.1371/journal.ppat.1006014. [PMID: 27829026]
  • Hook LM, Landais I, Hancock MH, Nelson JA. Techniques for characterizing cytomegalovirus-encoded miRNAs. Methods Mol Biol. 2014;1119:239-65. doi: 10.1007/978-1-62703-788-4_14.[PMID: 24639227]
  • Hancock MH, Tirabassi RS, Nelson JA. Rhesus cytomegalovirus encodes seventeen microRNAs that are differentially expressed in vitro and in vivo. Virology. 2012 Apr 10;425(2):133-42. doi: 10.1016/j.virol.2012.01.009. [PMID: 22305624]

Publications