Photo of Martha Neuringer, Ph.D.

Martha Neuringer Ph.D.

  •      (503) 346-5586
    • Research Associate Professor of Ophthalmology School of Medicine
    • Professor Oregon National Primate Research Center
    • Neuroscience Graduate Program School of Medicine

Dr. Neuringer’s major areas of research include 1) the development and characterization of nonhuman primate models of retinal diseases, including age-related macular degeneration, the leading cause of vision loss in the elderly; 2) preclinical studies of gene and cell-based therapies for retinal disease; 2) the role of nutritonal factors – particularly omega-3 fatty acids and carotenoids – in retinal and brain development, aging and disease; and 4) cognitive aging its modulation by ovarian hormones.

Areas of interest

  • Retinal degenerative disease
  • Nutritional factors in development and aging of the retina and brain
  • Gene and cell therapies for retinal disease
  • Cognitive aging

Education

  • B.A., Harvard/Radcliffe, Cambridge Massachusetts United States 1966
  • Ph.D., Harvard University, Cambridge Massachusetts United States 1971
  • Ph.D., Harvard University 1971
  • Fellowship:

    • Postdoctoral Fellowship, ONPRC

Honors and awards

  • OHSU Distinguished Science Educator Award, 2003
  • International Life Sciences Institute: Certificate of Achievement for one of 20 most cited papers in 70-year history of Nutrition Reviews
  • OHSU Technology Innovation/Industry Collaboration Award, 2012 and 2014
  • Fellow, International Carotenoid Society, 2017

Memberships and associations

  • Association for Research in Vision and Ophthalmology
  • Society for Neuroscience
  • American Society for Nutrition
  • International Carotenoid Society

Publications

Selected publications

  • McGill TJ, Renner L, Neuringer M. Elevated fundus autofluorescence in monkeys deficient inlutein, zeaxanthin, and omega-3 fatty acids. Invest Ophthalmol Vis Sci 57:1361-1369, 2016.

  • Kohama SG, Renner L, Landauer N, Weiss AR, Urbanski HF, Park B, Voytko ML, Neuringer M. Effect of ovarian hormone therapy on cognition in the aged female rhesus macaque. J Neurosci. 36:10416-10424, 2016.

  • Pennesi ME, Garg AK, Feng S, Michaels KV, Smith TB, Fay JD, Weiss AR, Renner LM, Hurst S, McGill TJ, Cornea A, Rittenhouse KD, Sperling M, Fruebis J, Neuringer M.  Measuring cone density in a Japanese macaque (Macaca fuscata) model of age-related macular degeneration with commercially available adaptive optics.  Advances in Experimental Medicine and Biology 801:309-316, 2014

  • Koilkonda RD, Yu H, Chou TH, Feuer WJ, Ruggeri M, Porciatti V, Tse D, Hauswirth WW, Chiodo V, Boye SL, Lewin AS, Neuringer M, Renner L, Guy J.  Safety and efficacy of the vector for the Leber’s hereditary optic neuropathy gene therapy clinical trial.  JAMA Ophthalmology, 132(4):409-420, 2014.

  • Grayson DS, Kroenke CD, Neuringer M, Fair DA.  Dietary omega-3 fatty acids modulate large-scale systems organization in the rhesus macaque brain.  J Neurosci 34(6):2065–2074, 2014. 

  • Wilson DJ, Neuringer M, Stoddard J, Renner LM, Bailey S, Lauer A, McGill TJ. Subretinal cell based therapy: An analysis of surgical variables to increase cell survival. Retina 2017 Jan 16. doi: 10.1097/IAE.0000000000001462.

Publications

  • "Discovery of a CLN7 model of Batten disease in non-human primates." Neurobiology of Disease In: , Vol. 119, 01.11.2018, p. 65-78.
  • "Relationships of carotenoid-related gene expression and serum cholesterol and lipoprotein levels to retina and brain lutein deposition in infant rhesus macaques following 6 months of breastfeeding or formula feeding." Archives of Biochemistry and Biophysics In: , Vol. 654, 15.09.2018, p. 97-104.
  • "The Ultrastructure, Spatial Distribution, and Osmium Tetroxide Binding of Lipofuscin and Melanosomes in Aging Monkey Retinal Epithelium." Current Eye Research  In: , 12.05.2018, p. 1-5.
  • "Allogeneic iPSC-derived RPE cell graft failure following transplantation into the subretinal space in nonhuman primates." Investigative Ophthalmology and Visual Science  In: , Vol. 59, No. 3, 01.03.2018, p. 1374-1383.
  • "Lutein is differentially deposited across brain regions following formula or breast feeding of infant rhesus macaques." Journal of Nutrition In: , Vol. 148, No. 1, 01.01.2018, p. 31-39.
  • "Cell transplantation for retinal degeneration : Transition from rodent to nonhuman primate models."   Advances in Experimental Medicine and Biology. Springer New York LLC, 2018. p. 641-647 (Advances in Experimental Medicine and Biology; Vol. 1074).
  • "The subcellular distribution of alpha-tocopherol in the adult primate brain and its relationship with membrane arachidonic acid and its oxidation products." Antioxidants In: , Vol. 6, No. 4, 97, 01.12.2017.
  • "Lutein accumulates in subcellular membranes of brain regions in adult rhesus macaques : Relationship to DHA oxidation products." PLoS ONE In: , Vol. 12, No. 10, e0186767, 01.10.2017.
  • "Brain xanthophyll content and exploratory gene expression analysis : Subspecies differences in rhesus macaque." Genes and Nutrition In: , Vol. 12, No. 1, 9, 08.03.2017.
  • "Cognition in aged rhesus monkeys : effect of DHEA and correlation with steroidogenic gene expression." Genes, Brain and Behavior In: , Vol. 16, No. 3, 01.03.2017, p. 361-368.
  • "Carrot solution culture bioproduction of uniformly labeled C-lutein and in vivo dosing in non-human primates." Experimental Biology and Medicine In: , Vol. 242, No. 3, 01.02.2017, p. 305-315.
  • "SUBRETINAL CELL-BASED THERAPY : An Analysis of Surgical Variables to Increase Cell Survival." Retina In: , 16.01.2017.
  • "Effect of carotenoid supplemented formula on carotenoid bioaccumulation in tissues of infant rhesus macaques : A pilot study focused on lutein." Nutrients In: , Vol. 9, No. 1, 51, 10.01.2017.
  • "Administration of tauroursodeoxycholic acid prevents endothelial dysfunction caused by an oral glucose load." Clinical science (London, England : 1979)  In: , Vol. 130, No. 21, 01.11.2016, p. 1881-1888.
  • "Effect of ovarian hormone therapy on cognition in the aged female rhesus macaque." Journal of Neuroscience  In: , Vol. 36, No. 40, 05.10.2016, p. 10416-10424.
  • "Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques." Anesthesiology In: , 05.10.2016.
  • "Mitochondrial elongation in the macular RPE of aging monkeys, evidence of metabolic stress." Graefe's Archive for Clinical and Experimental Ophthalmology In: , 22.04.2016, p. 1-7.
  • "Elevated fundus autofluorescence in monkeys deficient in lutein, zeaxanthin, and omega-3 fatty acids." Investigative Ophthalmology and Visual Science  In: , Vol. 57, No. 3, 01.03.2016, p. 1361-1369.
  • "Erratum : Safety and biodistribution evaluation in cynomolgus macaques of rAAV2tYF-CB-hRS1, a recombinant adeno-associated virus vector expressing retinoschisin (Human Gene Therapy Clinical Development (2015) 26:3 (165-176))." Human Gene Therapy Clinical Development In: , Vol. 26, No. 4, 01.12.2015, p. 243.
  • "LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA : Biodistribution and toxicology profile." Investigative Ophthalmology and Visual Science  In: , Vol. 55, No. 12, 23.10.2014, p. 7739-7753.
  • "Macular xanthophylls, lipoprotein-related genes, and age-related macular degeneration." American Journal of Clinical Nutrition  In: , Vol. 100, No. SUPPL. 1, 01.07.2014.
  • "Androgen supplementation during aging : Development of a physiologically appropriate protocol." Rejuvenation Research In: , Vol. 17, No. 2, 01.04.2014, p. 150-153.
  • "Comment on : What is meso-zeaxanthin, and where does it come from?" Eye (Basingstoke) In: , Vol. 28, No. 2, 02.2014, p. 240-242.
  • "Dietary omega-3 fatty acids modulate large-scale systems organization in the rhesus macaque brain." Journal of Neuroscience In: , Vol. 34, No. 6, 2014, p. 2065-2074.
  • "Measuring cone density in a Japanese macaque (Macaca fuscata) model of age-related macular degeneration with commercially available adaptive optics." Advances in Experimental Medicine and Biology  In: , Vol. 801, 2014, p. 309-316.
  • "Safety and effects of the vector for the leber hereditary optic neuropathy gene therapy clinical trial." JAMA Ophthalmology  In: , Vol. 132, No. 4, 2014, p. 409-420.
  • "Macular lutein and zeaxanthin are related to brain lutein and zeaxanthin in primates." Nutritional Neuroscience In: , Vol. 16, No. 1, 01.2013, p. 21-29.
  • "Changes in Spontaneous Activity Assessed by Accelerometry Correlate with Extent of Cerebral Ischemia-Reperfusion Injury in the Nonhuman Primate." Translational Stroke Research  In: , Vol. 3, No. 4, 12.2012, p. 442-451.
  • "The putative role of lutein and zeaxanthin as protective agents against age-related macular degeneration : Promise of molecular genetics for guiding mechanistic and translational research in the field." American Journal of Clinical Nutrition  In: , Vol. 96, No. 5, 11.2012.
  • "Animal models of age related macular degeneration." Molecular Aspects of Medicine In: , Vol. 33, No. 4, 08.2012, p. 487-509.

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