Dr. Neuringer’s major areas of research include 1) the development and characterization of nonhuman primate models of retinal diseases, including age-related macular degeneration, the leading cause of vision loss in the elderly; 2) preclinical studies of gene and cell-based therapies for retinal disease; 2) the role of nutritonal factors – particularly omega-3 fatty acids and carotenoids – in retinal and brain development, aging and disease; and 4) cognitive aging its modulation by ovarian hormones.
Areas of interest
- Retinal degenerative disease
- Nutritional factors in development and aging of the retina and brain
- Gene and cell therapies for retinal disease
- Cognitive aging
- B.A., Harvard/Radcliffe, Cambridge Massachusetts United States 1966
- Ph.D., Harvard University, Cambridge Massachusetts United States 1971
- Ph.D., Harvard University 1971
- Postdoctoral Fellowship, ONPRC
Honors and awards
- OHSU Distinguished Science Educator Award, 2003
- International Life Sciences Institute: Certificate of Achievement for one of 20 most cited papers in 70-year history of Nutrition Reviews
- OHSU Technology Innovation/Industry Collaboration Award, 2012 and 2014
- Fellow, International Carotenoid Society, 2017
Memberships and associations
- Association for Research in Vision and Ophthalmology
- Society for Neuroscience
- American Society for Nutrition
- International Carotenoid Society
McGill TJ, Renner L, Neuringer M. Elevated fundus autofluorescence in monkeys deficient inlutein, zeaxanthin, and omega-3 fatty acids. Invest Ophthalmol Vis Sci 57:1361-1369, 2016.
Kohama SG, Renner L, Landauer N, Weiss AR, Urbanski HF, Park B, Voytko ML, Neuringer M. Effect of ovarian hormone therapy on cognition in the aged female rhesus macaque. J Neurosci. 36:10416-10424, 2016.
Pennesi ME, Garg AK, Feng S, Michaels KV, Smith TB, Fay JD, Weiss AR, Renner LM, Hurst S, McGill TJ, Cornea A, Rittenhouse KD, Sperling M, Fruebis J, Neuringer M. Measuring cone density in a Japanese macaque (Macaca fuscata) model of age-related macular degeneration with commercially available adaptive optics. Advances in Experimental Medicine and Biology 801:309-316, 2014
Koilkonda RD, Yu H, Chou TH, Feuer WJ, Ruggeri M, Porciatti V, Tse D, Hauswirth WW, Chiodo V, Boye SL, Lewin AS, Neuringer M, Renner L, Guy J. Safety and efficacy of the vector for the Leber’s hereditary optic neuropathy gene therapy clinical trial. JAMA Ophthalmology, 132(4):409-420, 2014.
Grayson DS, Kroenke CD, Neuringer M, Fair DA. Dietary omega-3 fatty acids modulate large-scale systems organization in the rhesus macaque brain. J Neurosci 34(6):2065–2074, 2014.
Wilson DJ, Neuringer M, Stoddard J, Renner LM, Bailey S, Lauer A, McGill TJ. Subretinal cell based therapy: An analysis of surgical variables to increase cell survival. Retina 2017 Jan 16. doi: 10.1097/IAE.0000000000001462.