Photo of Kathleen A. Grant, Ph.D.

Kathleen A. Grant Ph.D.

  • (503) 346-5461
    • Professor Oregon National Primate Research Center
    • Professor of Behavioral Neuroscience School of Medicine
    • Chief, Division of Neuroscience Oregon National Primate Research Center
    • Behavioral Neuroscience Graduate Program School of Medicine

Kathleen (Kathy) Grant, Ph.D. is Chief and Professor, Division of Neuroscience at the Oregon National Primate Research Center. Her scientific interests are in animal models of addiction, particularly alcoholism.

Her studies in non human primates are aimed at understanding the co-morbidity of stress and excessive alcohol drinking examining risk factors such genetics, in utero exposure, adolescent vulnerability, sex differences and menstrual cycle effects, brain adaptations and cognitive impairments.

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Areas of interest

  • Animal models of alcohol and drug addiction
  • Stress response to chronic alcohol drinking
  • MRI imaging of brain circuitry
  • Advances in cognitive assessment of primate behavior
  • Behavioral pharmacology

Education

  • B.S., University of Santa Clara 1979
  • M.S., University of Washington 1982
  • Ph.D., University of Washington 1984
  • Fellowship:

    • National Research Service Award, University of Chicago, 1984-1987

Honors and awards

  • 2009 - 2013 National Advisory Council, NIAAA
  • 2013 Henri Begleiter Excellence in Research Award, Research Society on Alcoholism
  • 2015 Master Lecture, 2015 American Psychological Association Convention
  • 2016-2018 President, Behavioral Pharmacology Society (BPS)
  • 2017 Plenary Lecture, Collaborative Perspectives on Addiction, APA

Memberships and associations

  • 1992- Alcoholism: Clinical and Experimental Research; 2001-present: Reviewing Editor
  • 1995- Behavioral Pharmacology
  • 2013- Alcohol
  • RSA, ASPET, SFN, APA, ISBRA

Publications

  • "Brain pathways to recovery from alcohol dependence" Alcohol August 1 2015
  • "Primate cerebellar granule cells exhibit a tonic GABAAR conductance that is not affected by alcohol" Frontiers in Neural Circuits November 26 2013
  • "Discriminative stimulus effects of ethanol" Behavioural Pharmacology November 2004
  • "Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic-pituitary-adrenal axis" Pharmacology Biochemistry and Behavior August 2006
  • "Up-regulation and functional effect of cardiac β3- adrenoreceptors in alcoholic monkeys" Alcoholism: Clinical and Experimental Research July 2010
  • "Diazepam self-administration and resistance to extinction" Pharmacology Biochemistry and Behavior  1987
  • "Genetic load is associated with hypothalamic-pituitary-adrenal axis dysregulation in macaques" Genes, Brain and Behavior  2012
  • "Characterization of the discriminative stimulus effects of the neuroactive steroid pregnanolone in DBA/2J and C57BL/6J inbred mice" Journal of Pharmacology and Experimental Therapeutics August 2005
  • "Ethanol withdrawal seizures and the NMDA receptor complex" European Journal of Pharmacology February 13 1990
  • "Long-acting depot formulation of luprolide acetate as a method of hypothalamic down regulation for controlled ovarian hyperstimulation and oocyte production in Macaca fascicularis" Biology of Reproduction June 1 2003
  • "Comparison of ethanol metabolism in male and female cynomolgus macaques (Macaca fascicularis)" Alcoholism: Clinical and Experimental Research April 1999
  • "Brain ethanol concentrations and ethanol discrimination in rats" Psychopharmacology July 2003
  • "Voluntary ethanol intake predicts κ-opioid receptor supersensitivity and regionally distinct dopaminergic adaptations in macaques" Journal of Neuroscience April 15 2015
  • "The nitric oxide synthase inhibitor L-NAME (Nω-nitro-L-arginine methyl ester) does not produce discriminative stimulus effects similar to ethanol" Alcoholism: Clinical and Experimental Research  1997
  • "Long-term ethanol self-administration by the nonhuman primate, Macaca fascicularis, decreases the benzodiazepine sensitivity of amygdala GABA A receptors" Alcoholism: Clinical and Experimental Research June 2007
  • "Effects of social status and moderate alcohol consumption on mammary gland and endometrium of surgically postmenopausal monkeys" Menopause  2004
  • "The influence of menstrual cycle phase on sensitivity to ethanol-like discriminative stimulus effects of GABA(A)-positive modulators" Pharmacology Biochemistry and Behavior October 1999
  • "Attenuation of the discriminative stimulus effects of ethanol by the benzodiazepine partial inverse agonist Ro 15-4513" Behavioural Pharmacology  1997
  • "Induction and maintenance of ethanol self-administration without food deprivation in the rat" Psychopharmacology August 1985
  • "Adrenal steroid hormones and ethanol self-administration in male rhesus macaques" Psychopharmacology September 1 2014
  • "The Future of Proteomics in the Study of Alcoholism" Alcoholism: Clinical and Experimental Research February 2004
  • "Examination of a CYP2E1 repeat polymorphism in a monkey model of alcohol abuse" Alcoholism: Clinical and Experimental Research  2001
  • "Induction and maintenance of ethanol self-administration in cynomolgus monkeys (Macaca fascicularis)" Alcoholism: Clinical and Experimental Research  2001
  • "Drinking to Dependence Risk Factors in Nonhuman Primates"  February 2014
  • "Ethanol and the NMDA receptor" Alcohol  1990
  • "The Effects of Moderate Ethanol Consumption on the Liver of the Monkey, Macaca fascicularis" Alcoholism: Clinical and Experimental Research November 2003
  • "Discriminative stimulus effects of ethanol and 3α-hydroxy-5α-pregnan-20-one in relation to menstrual cycle phase in cynomolgus monkeys (Macaca fascicularis)" Psychopharmacology  1997
  • "Twelve months of voluntary heavy alcohol consumption in male rhesus macaques suppresses intracortical bone remodeling" Bone February 1 2015
  • "Chlordiazepoxide effects on ethanol self-administration" Journal of the Experimental Analysis of Behavior May 1985
  • "Effect of social status on striatal dopamine D2 receptor binding characteristics in cynomolgus monkeys assessed with positron emission tomography" Synapse May 1998

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