Joseph Leffler, Ph.D.

  • Assistant Professor of Ophthalmology, School of Medicine
  • Casey Eye Institute, School of Medicine

Biography

Our lab seeks to understand the mechanisms underlying neuronal dysfunction in the retina during degenerative diseases such as glaucoma. 

The retina is a highly organized neural tissue that processes visual information, transmitting signals from photoreceptors through retinal ganglion cells to the brain via the optic nerve. By combining advanced imaging and electrophysiological techniques, we investigate how diseases such as glaucoma disrupt retinal circuitry and impair visual function.  

We take a multidisciplinary, collaborative approach to address fundamental questions in vision science and ophthalmology. Our research integrates large-scale multielectrode array recordings, patch-clamp electrophysiology, high-resolution confocal microscopy, behavioral assays, and transcriptomic analyses. By combining these complementary approaches, we aim to define the cellular and circuit mechanisms that govern visual processing in both healthy and diseased retinas.

Education and training

  • Degrees

    • Ph.D., 2021, Oregon Health & Science University

Areas of interest

  • Electrophysiology
  • Glaucoma
  • Visual Neuroscience
  • Circadian Rhythms

Publications

Publications