Photo of James E. Korkola, Ph.D.

James E. Korkola Ph.D.

  • (503) 494-4943
    • Assistant Professor of Biomedical Engineering School of Medicine
    • Biomedical Informatics Graduate Program School of Medicine

Dr. Korkola's research work is primarily on breast cancer, with a focus on how interactions with microenvironment impact the phenotype of cancer cells, emphasizing those that alter the way cells respond to therapy. The Korkola Lab also is interested in understanding the mechanisms of resistance induced by extrinsic and intrinsic factors and developing multidrug combinations to overcome resistance and improve patient outcomes.

Education

  • Ph.D., University of Toronto 1999

Publications

  • "Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer." Nature Chemical Biology  In: , 25.06.2018, p. 1-10.
  • "CCR5 Governs DNA damage repair and breast cancer stem cell expansion." Cancer Research  In: , Vol. 78, No. 7, 01.04.2018, p. 1657-1671.
  • "Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes." Cell Systems  In: , 01.01.2018.
  • "Quantification of sensitivity and resistance of breast cancer cell lines to anti-cancer drugs using GR metrics." Scientific data  In: , Vol. 4, 170166, 07.11.2017.
  • "Correction : Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer (PLoS ONE (2015) 10:7 (e0133219) DOI: 10.1371/journal.pone.0133219)." PLoS One  In: , Vol. 12, No. 10, e0186551, 01.10.2017.
  • "Erratum to : "Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer", [Breast Cancer Research, 19, (2017) (17)] DOI: 10.1186/s13058-017-0809-6." Breast Cancer Research  In: , Vol. 19, No. 1, 17, 09.02.2017.
  • "Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling." Cell Systems  In: , Vol. 4, No. 1, 25.01.2017, p. 73-83.e10.
  • "The Library of Integrated Network-Based Cellular Signatures NIH Program : System-Level Cataloging of Human Cells Response to Perturbations." Cell Systems  In: , 01.01.2017.
  • "Genome co-amplification upregulates a mitotic gene network activity that predicts outcome and response to mitotic protein inhibitors in breast cancer." Breast Cancer Research  In: , Vol. 18, No. 1, 70, 01.07.2016.
  • "Mechanism and Role of SOX2 Repression in Seminoma : Relevance to Human Germline Specification." Stem Cell Reports  In: , Vol. 6, No. 5, 10.05.2016, p. 772-783.
  • "Cellular androgen content influences enzalutamide agonism of F877L mutant androgen receptor." Oncotarget  In: , Vol. 7, No. 26, 2016, p. 40690.
  • "Development and validation of a gene-based model for outcome prediction in germ cell tumors using a combined genomic and expression profiling approach." PLoS One  In: , Vol. 10, No. 12, e0142846, 01.12.2015.
  • "Exome sequencing of cell-free DNA from metastatic cancer patients identifies clinically actionable mutations distinct from primary disease." PLoS One  In: , Vol. 10, No. 8, e0136407, 28.08.2015.
  • "Heterogeneity in cancer dynamics : A convex formulation to dissect dynamic trajectories and infer LTV models of networked systems."   Proceedings of the American Control Conference. Vol. 2015-July Institute of Electrical and Electronics Engineers Inc., 2015. p. 4398-4403 7172021.
  • "Decoupling of the PI3K pathway via mutation necessitates combinatorial treatment in HER2+ breast cancer." PLoS One  In: , Vol. 10, No. 7, e0133219, 16.07.2015.
  • "Erratum to Modeling precision treatment of breast cancer [Genome Biology, 14, (2013), R110]." Genome Biology  In: , Vol. 16, No. 1, 95, 12.05.2015.
  • "Disentangling multidimensional spatio-temporal data into their common and aberrant responses." PLoS One  In: , Vol. 10, No. 4, e0121607, 22.04.2015.
  • "Interrogation of a context-specific transcription factor network identifies novel regulators of pluripotency." Stem Cells  In: , Vol. 33, No. 2, 01.02.2015, p. 367-377.
  • "Joint estimation of multiple related biological networks." Annals of Applied Statistics  In: , Vol. 8, No. 3, 01.09.2014, p. 1892-1919.
  • "Causal network inference using biochemical kinetics." Bioinformatics  In: , Vol. 30, No. 17, 01.09.2014.
  • "Identification and quantification of AKT isoforms and phosphoforms in breast cancer using a novel nanofluidic immunoassay." Molecular and Cellular Proteomics  In: , Vol. 12, No. 11, 11.2013, p. 3210-3220.
  • "Modeling precision treatment of breast cancer." Genome Biology  In: , Vol. 14, No. 10, 2013.
  • "Cross-platform pathway-based analysis identifies markers of response to the PARP inhibitor olaparib." Breast Cancer Research and Treatment  In: , Vol. 135, No. 2, 09.2012, p. 505-517.
  • "A Central role for RAF→MEK→ERK signaling in the genesis of pancreatic ductal adenocarcinoma." Cancer Discovery  In: , Vol. 2, No. 8, 08.2012, p. 685-693.
  • "The transcription factor ZNF217 Is a prognostic biomarker and therapeutic target during breast cancer progression." Cancer Discovery  In: , Vol. 2, No. 7, 07.2012, p. 638-651.
  • "Subtype and pathway specific responses to anticancer compounds in breast cancer." Proceedings of the National Academy of Sciences of the United States of America  In: , Vol. 109, No. 8, 21.02.2012, p. 2724-2729.
  • "Integrated genomic analyses of ovarian carcinoma." Nature  In: , Vol. 474, No. 7353, 30.06.2011, p. 609-615.
  • "A genetic strategy for single and combinatorial analysis of miRNA function in mammalian hematopoietic stem cells." Stem Cells  In: , Vol. 28, No. 2, 02.2010, p. 287-296.
  • "Breast cancer genomes - form and function." Current Opinion in Genetics and Development  In: , Vol. 20, No. 1, 02.2010, p. 4-14.
  • "Identification and validation of a gene expression signature that predicts outcome in adult men with germ cell tumors." Journal of Clinical Oncology  In: , Vol. 27, No. 31, 01.11.2009, p. 5240-5247.

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