Hui Wu, Ph.D.

  • Professor of Integrative Biosciences, School of Dentistry
  • Associate Dean for Research, Dean's Office, School of Dentistry

Biography

Hui Wu, Ph.D., is OHSU School of Dentistry(SOD)’s Associate Dean for research. He heads Office of Research and coordinates research and research training at OHSU SOD. The office oversees a research enterprise that encompasses research strengths in biomaterials, tissue engineering and regerneration, and oral microbiology and immunology, and supports the development of clinical translational research and other areas of research excellence in neuroscience, cell and developmental biology, and public health dentistry, education and dental informatics.  He helps set the agenda for increasing SOD’s research outcomes and advancing research excellence.

Dr. Wu is also a professor of Integrative Biosciences in the OHSU SOD. He joined OHSU in March 2020 after a stellar career at the University of Alabama at Birmingham (UAB). Dr. Wu was a Professor of Dentistry and Microbiology at UAB. At UAB Dr. Wu led the university-wide Microbiome Research Center as the founding director and directed NIDCR/NIH supported training program. He has trained numerous graduate students, postdoctoral fellows and dentist scientists, and was selected as a recipient for 2014 UAB Graduate School Dean’s Award for Excellence in Mentorship.  Dr. Wu is an accomplished scientist, with more than 80 manuscripts published in mainstream journals and 17 years of research continously funded by the National Institutes of Health in microbial sciences. In 2011 Dr. Wu received IADR/GSK Innovation in Oral Care Award. In 2017 he was awarded the Outstanding Alumni Award by the University of Vermont College of Argicutlure and Life Sciences. In 2020, Dr. Wu was elected to American Academy of Microbiology as a Fellow for his contribution to microbial sciences.

Education

  • B.S., 1988, Nanjing Normal University
  • M.S., 1991, Fudan University
  • Ph.D., 1999, The University of Vermont

Honors and awards

  • 2020 Fellow, American Academy of Microbiology
  • 2017 Outstanding Alumni Award University of Vermont College of Agriculture and Life Sciences
  • 2014 UAB Graduate School Dean’s Award for Excellence in Mentorship
  • 2011 International Association for Dental Research/GSK Innovation in Oral Care Award
  • 2004 NIH/NIHDCR Scholar and Faculty Transition Award
  • 2020 Weight Endowed Professor in Research, OHSU

Memberships and associations

  • American Society for Microbiology
  • International Association for Dental Research

Areas of interest

  • Microbiome in health and disease
  • Polymicrobial interactions, and host-microbe interactions
  • Small molecule inhibitors of biofilms
  • Structure-based drug discovery of anti-biofilm agents
  • Protein glycosylation and secretion

Publications

Selected publications

  • Momeni SS, Beno SM, Baker JL, Edlund A, Ghazal T, Childers NK, Wu H. Caries-Associated Biosynthetic Gene Clusters in Streptococcus mutans. J Dent Res. 2020 Apr 16:22034520914519. doi: 10.1177/0022034520914519. [Epub ahead of print] PMID:32298190
  • Rainey K, Wilson L, Barnes S, Wu H. Quantitative Proteomics Uncovers the Interaction between a Virulence Factor and Mutanobactin Synthetases in Streptococcus mutans. mSphere. 2019 Sep 25;4(5). pii: e00429-19. doi: 10.1128/mSphere.00429-19. PMID:31554721  
  • Bowen WH, Burne RA, Wu H, Koo H. Oral Biofilms: Pathogens, Matrix, and Polymicrobial Interactions in Microenvironments. Trends Microbiol. 2018 Mar;26(3):229-242. doi: 10.1016/j.tim.2017.09.008. Epub 2017 Oct 30. Review. PMID:29097091
  • Ruby J, Martin M, Passineau MJ, Godovikova V, Fenno JC, Wu H. Activation of the Innate Immune System by Treponema denticola Periplasmic Flagella through Toll-Like Receptor 2. Infect Immun. 2017 Dec 19;86(1). pii: e00573-17. doi: 10.1128/IAI.00573-17. Print 2018 Jan. Erratum in: Infect Immun. 2018 Jun 21;86(7):.PMID:29084899
  • Sun Y, Byon CH, Yang Y, Bradley WE, Dell'Italia LJ, Sanders PW, Agarwal A, Wu H, Chen Y. Dietary potassium regulates vascular calcification and arterial stiffness. JCI Insight. 2017 Oct 5;2(19). pii: 94920. doi: 10.1172/jci.insight.94920. PMID:28978809
  • Zhang Q, Nijampatnam B, Hua Z, Nguyen T, Zou J, Cai X, Michalek SM, Velu SE, Wu H. Structure-Based Discovery of Small Molecule Inhibitors of Cariogenic Virulence. Sci Rep. 2017 Jul 20;7(1):5974. doi: 10.1038/s41598-017-06168-1. PMID:28729722
  • Scoffield JA, Duan D, Zhu F, Wu H. A commensal streptococcus hijacks a Pseudomonas aeruginosa exopolysaccharide to promote biofilm formation. PLoS Pathog. 2017 Apr 7;13(4):e1006300. doi: 10.1371/journal.ppat.1006300. eCollection 2017 Apr. PMID:28448633
  • Zhu F, Zhang H, Yang T, Haslam SM, Dell A, Wu H. Engineering and Dissecting the Glycosylation Pathway of a Streptococcal Serine-rich Repeat Adhesin.  J Biol Chem. 2016 Dec 30;291(53):27354-27363. doi: 10.1074/jbc.M116.752998. PMID:28039332  
  • Peng X, Zhang Y, Bai G, Zhou X, Wu H. Cyclic di-AMP mediates biofilm formation. Mol Microbiol. 2016 Mar;99(5):945-59. doi: 10.1111/mmi.13277. Epub 2015 Dec 15. PMID:26564551
  • Zhang H, Zhu F, Yang T, Ding L, Zhou M, Li J, Haslam SM, Dell A, Erlandsen H, Wu H. The highly conserved domain of unknown function 1792 has a distinct glycosyltransferase fold. Nat Commun. 2014 Jul 15;5:4339. doi: 10.1038/ncomms5339. PMID:25023666

Publications

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