Heidi S. Feiler, Ph.D., M.A.

  • Research Associate Professor of Biomedical Engineering, School of Medicine
  • Scientific Program Manager, OHSU Center for Spatial Systems Biomedicine, School of Medicine

Biography

Dr. Feiler is a Research Associate Professor and the Scientific Program Manager for the OHSU Center for Spatial System Biomedicine (OCSSB). Her work focuses on elucidating the genomic, transcriptional and proteomic abnormalities by which breast and pancreatic cancers arise, progress and respond to therapy. She studies the mechanisms by which these abnormalities contribute to cancer pathophysiologies and influence response to gene targeted therapies. Long-term goals are to develop strategies for earlier detection of cancers at high risk of progression to metastatic disease and more durable therapeutic approaches for advanced cancers .

Dr. Feiler is the Scientific Program Manager of three NIH-awarded Centers at OHSU:

(1) a NCI Cancer Systems Biology Consortium Center (U54) aimed at modeling the influence of tumor heterogeneity on therapeutic resistance. 

(2) a NIH Library of Integrated Network-Based Cellular Signature (LINCS) Perturbation-Induced Data and Signature Generation Center (U54) aimed at understanding the influence of microenvironmental perturbations on cell signaling network behavior.

(3) a NCI Human Tumor Atlas Network (U2C) OMS Atlas Center that performs comparative ‘omic and multiscale image analyses of responsive and resistant metastatic breast lesions within individual patients to discover mechanisms of resistance so they can be attacked therapeutically. 

Collaborating institutions involved in these programs include Harvard Medical School, the Dana Farber Cancer Institute, MD Anderson Cancer Center, University of California at Berkeley, University of California at San Francisco, University of California at Los Angeles, Lawrence Berkeley National Laboratory, City of Hope National Medical Center and Stanford University.

RECENT PUBLICATIONS

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution.
Rozenblatt-Rosen O, Regev A, Oberdoerffer P, Nawy T, Hupalowska A, Rood JE, Ashenberg O, Cerami E, Coffey RJ, Demir E, Ding L, Esplin ED, Ford JM, Goecks J, Ghosh S, Gray JW, Guinney J, Hanlon SE, Hughes SK, Hwang ES, Iacobuzio-Donahue CA, Jané-Valbuena J, Johnson BE, Lau KS, Lively T, Mazzilli SA, Pe'er D, Santagata S, Shalek AK, Schapiro D, Snyder MP, Sorger PK, Spira AE, Srivastava S, Tan K, West RB, Williams EH; Human Tumor Atlas Network.
Cell. 2020 Apr 16;181(2):236-249. doi: 10.1016/j.cell.2020.03.053. Review.
PMID: 32302568

A Multi-center Study on the Reproducibility of Drug-Response Assays in Mammalian Cell Lines.
Niepel M, Hafner M, Mills CE, Subramanian K, Williams EH, Chung M, Gaudio B, Barrette AM, Stern AD, Hu B, Korkola JE; LINCS Consortium, Gray JW, Birtwistle MR, Heiser LM, Sorger PK.
Cell Syst. 2019 Jul 24;9(1):35-48.e5. doi: 10.1016/j.cels.2019.06.005. Epub 2019 Jul 10.
PMID:  31302153

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.
Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma'ayan A, Stathias V, Terryn R, Cooper D, Forlin M, Koleti A, Vidovic D, Chung C, Schürer SC, Vasiliauskas J, Pilarczyk M, Shamsaei B, Fazel M, Ren Y, Niu W, Clark NA, White S, Mahi N, Zhang L, Kouril M, Reichard JF, Sivaganesan S, Medvedovic M, Meller J, Koch RJ, Birtwistle MR, Iyengar R, Sobie EA, Azeloglu EU, Kaye J, Osterloh J, Haston K, Kalra J, Finkbiener S, Li J, Milani P, Adam M, Escalante-Chong R, Sachs K, Lenail A, Ramamoorthy D, Fraenkel E, Daigle G, Hussain U, Coye A, Rothstein J, Sareen D, Ornelas L, Banuelos M, Mandefro B, Ho R, Svendsen CN, Lim RG, Stocksdale J, Casale MS, Thompson TG, Wu J, Thompson LM, Dardov V, Venkatraman V, Matlock A, Van Eyk JE, Jaffe JD, Papanastasiou M, Subramanian A, Golub TR, Erickson SD, Fallahi-Sichani M, Hafner M, Gray NS, Lin JR, Mills CE, Muhlich JL, Niepel M, Shamu CE, Williams EH, Wrobel D, Sorger PK, Heiser LM, Gray JW, Korkola JE, Mills GB, LaBarge M, Feiler HS, Dane MA, Bucher E, Nederlof M, Sudar D, Gross S, Kilburn DF, Smith R, Devlin K, Margolis R, Derr L, Lee A, Pillai A.
Cell Syst. 2018 Jan 24;6(1):13-24. doi: 10.1016/j.cels.2017.11.001. Epub 2017 Nov 29. Review.
PMID:  29199020

Publications

Publications

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